scholarly journals Continuous flow processing as a tool for the generation of terpene-derived monomer libraries

2019 ◽  
Vol 4 (2) ◽  
pp. 362-367 ◽  
Author(s):  
Renan Galaverna ◽  
Lucas P. Fernandes ◽  
Duncan L. Browne ◽  
Julio C. Pastre
Keyword(s):  
Continuous Flow ◽  
Alder Reaction ◽  
Diels Alder ◽  
Flow Conditions ◽  
Rapid Synthesis ◽  
Diels Alder Reaction

A Diels–Alder reaction employing terpenes for rapid synthesis of monomer libraries under flow conditions is presented.

scholarly journals Diels–Alder reactions of myrcene using intensified continuous-flow reactors

2017 ◽  
Vol 13 ◽  
pp. 120-126 ◽  
Author(s):  
Christian H Hornung ◽  
Miguel Á Álvarez-Diéguez ◽  
Thomas M Kohl ◽  
John Tsanaktsidis
Keyword(s):  
Continuous Flow ◽  
Flow Reactor ◽  
Scale Up ◽  
Reaction Times ◽  
Alder Reaction ◽  
Diels Alder ◽  
Flow Reactors ◽  
Diels Alder Reaction ◽  
Naturally Occurring ◽  
Continuous Flow Reactors

This work describes the Diels–Alder reaction of the naturally occurring substituted butadiene, myrcene, with a range of different naturally occurring and synthetic dienophiles. The synthesis of the Diels–Alder adduct from myrcene and acrylic acid, containing surfactant properties, was scaled-up in a plate-type continuous-flow reactor with a volume of 105 mL to a throughput of 2.79 kg of the final product per day. This continuous-flow approach provides a facile alternative scale-up route to conventional batch processing, and it helps to intensify the synthesis protocol by applying higher reaction temperatures and shorter reaction times.

scholarly journals Continuous flow of nitroso Diels–Alder reaction

2015 ◽  
Vol 51 (61) ◽  
pp. 12309-12312 ◽  
Author(s):  
Erika Nakashima ◽  
Hisashi Yamamoto
Keyword(s):  
Continuous Flow ◽  
Alder Reaction ◽  
Diels Alder ◽  
Reaction Systems ◽  
Diels Alder Reaction ◽  
Temperature And Pressure ◽  
Flow Reaction ◽  
Cyclic Dienes

Our flow reaction systems have provided quantitative yields of nitroso Diels–Alder products with no byproducts in cases of cyclic dienes without temperature and pressure controls.

scholarly journals Continuous-flow retro-Diels–Alder reaction: an efficient method for the preparation of pyrimidinone derivatives

2018 ◽  
Vol 14 ◽  
pp. 318-324 ◽  
Author(s):  
Imane Nekkaa ◽  
Márta Palkó ◽  
István M Mándity ◽  
Ferenc Fülöp
Keyword(s):  
Efficient Method ◽  
Continuous Flow ◽  
Reaction Times ◽  
Alder Reaction ◽  
Diels Alder ◽  
Diels Alder Reaction ◽  
Selection Of

The syntheses of various pyrimidinones as potentially bioactive products by means of the highly controlled continuous-flow retro-Diels–Alder reaction of condensed pyrimidinone derivatives are presented. Noteworthy, the use of this approach allowed us to rapidly screen a selection of conditions and quickly confirm the viability of preparing the desired pyrimidinones in short reaction times. Yields typically higher than those published earlier using conventional batch or microwave processes were achieved.

Development of a highly efficient single-mode microwave applicator with a resonant cavity and its application to continuous flow syntheses

RSC Advances ◽  
2015 ◽  
Vol 5 (14) ◽  
pp. 10204-10210 ◽  
Author(s):  
Saori Yokozawa ◽  
Noriyuki Ohneda ◽  
Ken Muramatsu ◽  
Tadashi Okamoto ◽  
Hiromichi Odajima ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Resonant Cavity ◽  
Single Mode ◽  
Alder Reaction ◽  
Diels Alder ◽  
Reaction Products ◽  
Fischer Indole Synthesis ◽  
Diels Alder Reaction ◽  
Microwave Applicator ◽  
Indole Synthesis

A new microwave applicator specifically designed for continuous flow synthesis has been developed and tested in the Fischer indole synthesis and in the Diels–Alder reaction to afford the reaction products at a scale of 100 g h−1.

Sign in / Sign up

Export Citation Format

Share Document