Solvent-free organocatalytic preparation of cyclic organic carbonates under scalable continuous flow conditions

2019 ◽  
Vol 4 (1) ◽  
pp. 17-26 ◽  
Author(s):  
Zhiguo Wang ◽  
Romaric Gérardy ◽  
Guillaume Gauron ◽  
Christian Damblon ◽  
Jean-Christophe M. Monbaliu
Keyword(s):  
Continuous Flow ◽  
Dimethyl Carbonate ◽  
Solvent Free ◽  
Flow Conditions ◽  
Organic Carbonates

A solvent-free organocatalyzed process for the transesterification of dimethyl carbonate (DMC) with 1,2-diols under scalable continuous flow conditions.

Metal- and solvent-free synthesis of aminoalcohols under continuous flow conditions

2020 ◽  
Vol 5 (2) ◽  
pp. 289-299 ◽  
Author(s):  
Abdo-Alslam Alwakwak ◽  
Yingxin He ◽  
Ahmed Almuslem ◽  
Matthew Senter ◽  
Arun K. Itta ◽  
...  
Keyword(s):  
Chemical Transformation ◽  
Hollow Fiber ◽  
Continuous Flow ◽  
Heterogeneous Catalysts ◽  
Flow Reactor ◽  
Solvent Free ◽  
Flow Conditions ◽  
Continuous Flow Reactor ◽  
Solvent Free Synthesis

Multifunctional organocatalysts were immobilized on porous hollow fiber polymer and used as intelligent and cooperative heterogeneous catalysts and continuous flow reactor for sustainable chemical transformation.

Versatile and scalable synthesis of cyclic organic carbonates under organocatalytic continuous flow conditions

2019 ◽  
Vol 9 (24) ◽  
pp. 6841-6851 ◽  
Author(s):  
Romaric Gérardy ◽  
Julien Estager ◽  
Patricia Luis ◽  
Damien P. Debecker ◽  
Jean-Christophe M. Monbaliu
Keyword(s):  
Continuous Flow ◽  
Flow Conditions ◽  
Flow Process ◽  
Organic Carbonates ◽  
Scalable Synthesis

A scalable intensified flow process for the preparation of cyclic organic carbonates relying on a cheap ammonium organocatalyst.

An entirely solvent-free photooxygenation of olefins under continuous flow conditions

2020 ◽  
Vol 22 (8) ◽  
pp. 2359-2364 ◽  
Author(s):  
Patrick Bayer ◽  
Axel Jacobi von Wangelin
Keyword(s):  
Singlet Oxygen ◽  
Continuous Flow ◽  
Flow Reactor ◽  
Space Time ◽  
Solvent Free ◽  
Flow Conditions ◽  
High Substrate ◽  
Solvent Free Conditions ◽  
High Space ◽  
Very High

Photooxygenations of alkenes with singlet oxygen have been performed under solvent-free conditions in a flow reactor under VIS irradiation. The reaction operates at very high substrate/sensitizer ratios and enables high space–time yields.

Metal–organic frameworks for the removal of the emerging contaminant atenolol under real conditions

2021 ◽  
Vol 50 (7) ◽  
pp. 2493-2500
Author(s):  
Sara Rojas ◽  
Jorge A. R. Navarro ◽  
Patricia Horcajada
Keyword(s):  
Continuous Flow ◽  
Metal Organic Frameworks ◽  
Fixed Bed ◽  
Emerging Contaminant ◽  
Flow Conditions ◽  
Metal Organic ◽  
Fixed Bed System

A defective Metal-Organic Frameworks as an improved material for the construction of a fixed-bed system working under continuous flow conditions for the removal of the emerging contaminant atenolol.

scholarly journals Formation and Utility of Reactive Ketene Intermediates Under Continuous Flow Conditions

Tetrahedron ◽  
2021 ◽  
pp. 132305
Author(s):  
Harry R. Smallman ◽  
Jamie A. Leitch ◽  
Tom McBride ◽  
Steven V. Ley ◽  
Duncan L. Browne
Keyword(s):  
Continuous Flow ◽  
Flow Conditions

scholarly journals Achieving selectivity in porphyrin bromination through a DoE-driven optimization under continuous flow conditions

2020 ◽  
Author(s):  
Paolo Zardi ◽  
Michele Maggini ◽  
Tommaso Carofiglio
Keyword(s):  
Reaction Time ◽  
Design Of Experiment ◽  
Continuous Flow ◽  
Optimization Process ◽  
Porphyrin Ring ◽  
Flow Conditions ◽  
Reaction Parameters ◽  
Synthetic Procedure ◽  
Relevant Factors ◽  
Post Functionalization

AbstractThe post-functionalization of porphyrins through the bromination in β position of the pyrrolic rings is a relevant transformation because the resulting bromoderivatives are useful synthons to covalently link a variety of chemical architectures to a porphyrin ring. However, single bromination of porphyrins is a challenging reaction for the abundancy of reactive β-pyrrolic positions in the aromatic macrocycle. We herein report a synthetic procedure for the efficient preparation of 2-bromo-5,10,15,20-tetraphenylporphyrin (1) under continuous flow conditions. The use of flow technology allows to reach an accurate control over critical reaction parameters such as temperature and reaction time. Furthermore, by performing the optimization process through a statistical DoE (Design of Experiment) approach, these parameters could be properly adjusted with a limited number of experiments. This process led us to a better understanding of the relevant factors that govern porphyrins monobromination and to obtain compound 1 with an unprecedent 80% yield.

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