scholarly journals Formulation, characterization and evaluation of morusin loaded niosomes for potentiation of anticancer therapy

RSC Advances ◽  
2018 ◽  
Vol 8 (57) ◽  
pp. 32621-32636 ◽  
Author(s):  
Srishti Agarwal ◽  
M. Sheikh Mohamed ◽  
Sreejith Raveendran ◽  
Ankit K. Rochani ◽  
Toru Maekawa ◽  
...  
Keyword(s):  
Sustained Release ◽  
Cell Lines ◽  
Cancer Cell ◽  
Therapeutic Efficacy ◽  
Drug Loading ◽  
Anticancer Therapy ◽  
Cancer Cell Lines ◽  
High Drug ◽  
High Drug Loading

Highly cytocompatible morusin-loaded niosomes were synthesized showing high drug loading and encapsulation efficiencies with sustained release of the drug. Enhanced therapeutic efficacy was observed against 4 different cancer cell lines.

Loading of capsaicin-in-cyclodextrin inclusion complexes into PEGylated liposomes and the inhibitory effect on IL-8 production by MDA-MB-231 and A549 cancer cell lines

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Hiba Abdelnabi ◽  
Walhan Alshaer ◽  
Hanan Azzam ◽  
Dana Alqudah ◽  
Ali Al-Samydai ◽  
...  
Keyword(s):  
Cell Lines ◽  
Inclusion Complexes ◽  
Cancer Cell ◽  
Drug Loading ◽  
Cancer Cell Lines ◽  
Inhibitory Effect ◽  
Hydrodynamic Diameter ◽  
Pegylated Liposomes ◽  
Cyclodextrin Inclusion Complexes ◽  
Extrusion Method

Abstract Capsaicin (CAP) is an active component in Capsicum annuum L. known to have anti inflammatory and anticancer activity. CAP is highly lipophilic and suffers low bioavailability. Therefore, developing delivery systems that enhance solubility and bioavailability can provide more promising therapeutic applications for CAP. In the current work, CAP was complexed with β-cyclodextrin (βCD) to form capsaicin-in-β-cyclodextrin (CAP-in-βCD) inclusion complexes. Then, the CAP-in-βCD inclusion complexes were characterized and loaded into PEGylated liposomes using the thin-film hydration extrusion method. The size, charge, and polydispersity index (PDI) of the PEGylated liposomes were characterized. The levels of IL-8 production were quantified after treatment using array beads. The results of this work showed that the successful formation of inclusion complexes at 1:5 M ratio of CAP to βCD respectively. PEGylated liposomes loaded with βCD/CAP inclusion complexes (CAP-in-βCD-in-liposomes) have a hydrodynamic diameter of (181 ± 36) nm, zeta potential of (−2.63 ± 4.00) mV, encapsulation efficiency (EE) of (38.65 ± 3.70)%, drug loading (DL) of (1.65 ± 0.16)%, and a stable release profile. Both free CAP and liposomal CAP showed a significant reduction in the IL-8 production by the MDA-MB-231 and A549 cancer cell lines after treatment. In conclusion, a liposomal-based drug delivery system for CAP was achieved.

Supramolecular micellar drug delivery system based on multi-arm block copolymer for highly effective encapsulation and sustained-release chemotherapy

2019 ◽  
Vol 7 (37) ◽  
pp. 5677-5687 ◽  
Author(s):  
Li Zhang ◽  
Dongjian Shi ◽  
Chunling Shi ◽  
Tatsuo Kaneko ◽  
Mingqing Chen
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Sustained Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Loading ◽  
High Drug ◽  
Release Drug ◽  
Drug Loading Efficiency ◽  
High Drug Loading

A novel multi-arm polyphosphoester-based nanomaterial provides high drug loading efficiency and sustained-release drug delivery for effective chemotherapy.

Sustained release of PI3K inhibitor from PHA nanoparticles and in vitro growth inhibition of cancer cell lines

2011 ◽  
Vol 89 (5) ◽  
pp. 1423-1433 ◽  
Author(s):  
Xiao-Yun Lu ◽  
Elisa Ciraolo ◽  
Rachele Stefenia ◽  
Guo-Qiang Chen ◽  
Yali Zhang ◽  
...  
Keyword(s):  
Sustained Release ◽  
Growth Inhibition ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Pi3k Inhibitor ◽  
In Vitro Growth

scholarly journals Schiff-Linked PEGylated Doxorubicin Prodrug Forming pH-Responsive Nanoparticles With High Drug Loading and Effective Anticancer Therapy

2021 ◽  
Vol 11 ◽  
Author(s):  
Jian Song ◽  
Bingbing Xu ◽  
Hui Yao ◽  
Xiaofang Lu ◽  
Yang Tan ◽  
...  
Keyword(s):  
Drug Release ◽  
Tumor Cells ◽  
Drug Loading ◽  
Drug Carriers ◽  
Anticancer Therapy ◽  
Therapeutic Effects ◽  
Ph Responsive ◽  
High Drug ◽  
High Drug Loading ◽  
Mcf 7

Developing efficacious drug delivery systems for targeted cancer chemotherapy remains a major challenge. Here we demonstrated a kind of pH-responsive PEGylated doxorubicin (DOX) prodrug via the effective esterification and Schiff base reactions, which could self-assemble into the biodegradable micelles in aqueous solutions. Owing to low pH values inside the tumor cells, these PEG-Schiff-DOX nanoparticles exhibited high drug loading ability and pH-responsive drug release behavior within the tumor cells or tissues upon changes in physical and chemical environments, but they displayed good stability at physiological conditions for a long period. CCK-8 assay showed that these PEGylated DOX prodrugs had a similar cytotoxicity to the MCF-7 tumor cells as the free DOX drug. Moreover, this kind of nanoparticle could also encapsulate small DOX drugs with high drug loading, sufficient drug release and enhanced therapeutic effects toward MCF-7 cells, which will be benefited for developing more drug carriers with desirable functions for clinical anticancer therapy.

Nanoscale covalent organic frameworks as smart carriers for drug delivery

2016 ◽  
Vol 52 (22) ◽  
pp. 4128-4131 ◽  
Author(s):  
Linyi Bai ◽  
Soo Zeng Fiona Phua ◽  
Wei Qi Lim ◽  
Avijit Jana ◽  
Zhong Luo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Drug Loading ◽  
Drug Carriers ◽  
Loading Capacity ◽  
Covalent Organic Frameworks ◽  
High Drug ◽  
Good Biocompatibility ◽  
High Drug Loading

Two nanoscale covalent organic frameworks as drug carriers with good biocompatibility were developed, showing high drug loading capacity and sustained release in vitro.

A nanofiber-based drug depot with high drug loading for sustained release

2020 ◽  
Vol 583 ◽  
pp. 119397 ◽  
Author(s):  
Jiangsong Hou ◽  
Jinke Yang ◽  
Xiaolu Zheng ◽  
Menglong Wang ◽  
Yanan Liu ◽  
...  
Keyword(s):  
Sustained Release ◽  
Drug Loading ◽  
High Drug ◽  
High Drug Loading

Importance of Encapsulation Stability of Nanocarriers with High Drug Loading Capacity for Increasing in Vivo Therapeutic Efficacy

2018 ◽  
Vol 19 (7) ◽  
pp. 3030-3039 ◽  
Author(s):  
L. Palanikumar ◽  
Eun Seong Choi ◽  
Jun Yong Oh ◽  
Soo Ah Park ◽  
Huyeon Choi ◽  
...  
Keyword(s):  
Therapeutic Efficacy ◽  
Drug Loading ◽  
Loading Capacity ◽  
High Drug ◽  
High Drug Loading

scholarly journals Galactose Oxidase Enables Modular Assembly of Conjugates from Native Antibodies with High Drug-to-Antibody Ratios

2021 ◽  
Author(s):  
Antonio Angelastro ◽  
Alexey Barkhanskiy ◽  
Ashley P. Mattey ◽  
Edward G. Pallister ◽  
Reynard Spiess ◽  
...  
Keyword(s):  
Drug Loading ◽  
Anticancer Therapy ◽  
Galactose Oxidase ◽  
Reaction Conditions ◽  
Modular Assembly ◽  
High Drug ◽  
Drug Conjugates ◽  
Antibody Conjugates ◽  
High Drug Loading ◽  
Antibody Drug

The potential of antibody conjugates with high drug loading in anticancer therapy has recently been highlighted by the approval of Trastuzumab deruxtecan and Sacituzumab govitecan. These biopharmaceutical approaches have spurred interest in bioconjugation strategies with high and defined degrees antibody-to-drug (DAR) ratios, in particular on native antibodies. Here we report a glycoengineering methodology to generate antibody drug conjugates with DAR of up to eight, by combining highly selective enzymatic galactosylation and oxidation with biorthogonal tandem Knoevenagel-Michael addition chemistry. This three step approach offers a selective route to conjugates from native antibodies with high drug loading, and thus illustrates how biocatalysis can be used for the generation of biopharmaceuticals using mild reaction conditions.

Achieving High Drug Loading and Sustained Release of Hydrophobic Drugs in Hydrogels through In Situ Crystallization

2016 ◽  
Vol 17 (3) ◽  
pp. 1600299 ◽  
Author(s):  
Tianyuan Ci ◽  
Yuning Shen ◽  
Shuquan Cui ◽  
Ruili Liu ◽  
Lin Yu ◽  
...  
Keyword(s):  
Sustained Release ◽  
Drug Loading ◽  
Hydrophobic Drugs ◽  
High Drug ◽  
In Situ Crystallization ◽  
High Drug Loading
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