Achieving High Drug Loading and Sustained Release of Hydrophobic Drugs in Hydrogels through In Situ Crystallization

2016 ◽  
Vol 17 (3) ◽  
pp. 1600299 ◽  
Author(s):  
Tianyuan Ci ◽  
Yuning Shen ◽  
Shuquan Cui ◽  
Ruili Liu ◽  
Lin Yu ◽  
...  
Keyword(s):  
Sustained Release ◽  
Drug Loading ◽  
Hydrophobic Drugs ◽  
High Drug ◽  
In Situ Crystallization ◽  
High Drug Loading

Supramolecular micellar drug delivery system based on multi-arm block copolymer for highly effective encapsulation and sustained-release chemotherapy

2019 ◽  
Vol 7 (37) ◽  
pp. 5677-5687 ◽  
Author(s):  
Li Zhang ◽  
Dongjian Shi ◽  
Chunling Shi ◽  
Tatsuo Kaneko ◽  
Mingqing Chen
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Sustained Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Loading ◽  
High Drug ◽  
Release Drug ◽  
Drug Loading Efficiency ◽  
High Drug Loading

A novel multi-arm polyphosphoester-based nanomaterial provides high drug loading efficiency and sustained-release drug delivery for effective chemotherapy.

A thermo-sensitive, injectable and biodegradable in situ hydrogel as a potential formulation for uveitis treatment

2019 ◽  
Vol 7 (28) ◽  
pp. 4402-4412 ◽  
Author(s):  
Mengwei Zou ◽  
Rongrong Jin ◽  
Yanfei Hu ◽  
Ying Zhang ◽  
Haibo Wang ◽  
...  
Keyword(s):  
Drug Release ◽  
Loading Rate ◽  
Histopathological Examination ◽  
Drug Loading ◽  
Sustained Drug Release ◽  
High Drug ◽  
Potential Formulation ◽  
In Situ Hydrogel ◽  
High Drug Loading

The thermo-sensitive hydrogels with high drug loading rate achieved sustained drug release over 2 weeks. Histopathological examination of retina confirmed the excellent biocompatibility and effective anti-inflammatory property of the hydrogel.

Nanoscale covalent organic frameworks as smart carriers for drug delivery

2016 ◽  
Vol 52 (22) ◽  
pp. 4128-4131 ◽  
Author(s):  
Linyi Bai ◽  
Soo Zeng Fiona Phua ◽  
Wei Qi Lim ◽  
Avijit Jana ◽  
Zhong Luo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Drug Loading ◽  
Drug Carriers ◽  
Loading Capacity ◽  
Covalent Organic Frameworks ◽  
High Drug ◽  
Good Biocompatibility ◽  
High Drug Loading

Two nanoscale covalent organic frameworks as drug carriers with good biocompatibility were developed, showing high drug loading capacity and sustained release in vitro.

High-Drug-Loading Amorphous Solid Dispersions via In Situ Thermal Cross-Linking: Unraveling the Mechanisms of Stabilization

2021 ◽  
Author(s):  
Afroditi Kapourani ◽  
Eleftherios G. Andriotis ◽  
Konstantina Chachlioutaki ◽  
Konstantinos N. Kontogiannopoulos ◽  
Panagiotis A. Klonos ◽  
...  
Keyword(s):  
Drug Loading ◽  
Solid Dispersions ◽  
Amorphous Solid ◽  
Cross Linking ◽  
Amorphous Solid Dispersions ◽  
High Drug ◽  
High Drug Loading

A nanofiber-based drug depot with high drug loading for sustained release

2020 ◽  
Vol 583 ◽  
pp. 119397 ◽  
Author(s):  
Jiangsong Hou ◽  
Jinke Yang ◽  
Xiaolu Zheng ◽  
Menglong Wang ◽  
Yanan Liu ◽  
...  
Keyword(s):  
Sustained Release ◽  
Drug Loading ◽  
High Drug ◽  
High Drug Loading

scholarly journals Formulation, characterization and evaluation of morusin loaded niosomes for potentiation of anticancer therapy

RSC Advances ◽  
2018 ◽  
Vol 8 (57) ◽  
pp. 32621-32636 ◽  
Author(s):  
Srishti Agarwal ◽  
M. Sheikh Mohamed ◽  
Sreejith Raveendran ◽  
Ankit K. Rochani ◽  
Toru Maekawa ◽  
...  
Keyword(s):  
Sustained Release ◽  
Cell Lines ◽  
Cancer Cell ◽  
Therapeutic Efficacy ◽  
Drug Loading ◽  
Anticancer Therapy ◽  
Cancer Cell Lines ◽  
High Drug ◽  
High Drug Loading

Highly cytocompatible morusin-loaded niosomes were synthesized showing high drug loading and encapsulation efficiencies with sustained release of the drug. Enhanced therapeutic efficacy was observed against 4 different cancer cell lines.

Investigating the influence of aromatic moieties on the formulation of hydrophobic natural products and drugs in poly(2-oxazoline) based amphiphiles

2018 ◽  
Author(s):  
Robert Luxenhofer ◽  
Michael M Lübtow ◽  
Lukas Hahn ◽  
Thomas Lorson ◽  
Rainer Schobert
Keyword(s):  
Natural Products ◽  
Small Molecules ◽  
Water Solubility ◽  
Drug Loading ◽  
High Drug ◽  
Long Term Stability ◽  
Aromatic Content ◽  
Important Interaction ◽  
Amorphous Structures ◽  
High Drug Loading

Many natural compounds with interesting biomedical properties share one physicochemical property, namely a low water solubility. Polymer micelles are, among others, a popular means to solubilize hydrophobic compounds. The specific molecular interactions between the polymers and the hydrophobic drugs are diverse and recently it has been discussed that macromolecular engineering can be used to optimize drug loaded micelles. Specifically, π-π stacking between small molecules and polymers has been discussed as an important interaction that can be employed to increase drug loading and formulation stability. Here, we test this hypothesis using four different polymer amphiphiles with varying aromatic content and various natural products that also contain different relative amounts of aromatic moieties. While in the case of paclitaxel, having the lowest relative content of aromatic moieties, the drug loading decreases with increasing relative aromatic amount in the polymer, the drug loading of curcumin, having a much higher relative aromatic content, is increased. Interestingly, the loading using schizandrin A, a dibenzo[a,c]cyclooctadiene lignan with intermediate relative aromatic content is not influenced significantly by the aromatic content of the polymers employed. The very high drug loading, long term stability, the ability to form stable highly loaded binary coformulations in different drug combinations, small sized formulations and amorphous structures in all cases, corroborate earlier reports that poly(2-oxazoline) based micelles exhibit an extraordinarily high drug loading and are promising candidates for further biomedical applications. The presented results underline that the interaction between the polymers and the incorporated small molecules are complex and must be investigated in every specific case.<br>

Design of dual-responsive nanocarries with high drug loading capacity based on hollow mesoporous organosilica nanoparticles

2019 ◽  
Vol 233 ◽  
pp. 230-235 ◽  
Author(s):  
Li-li Lu ◽  
Wen-ya Xiong ◽  
Jun-bin Ma ◽  
Tian-fang Gao ◽  
Si-yuan Peng ◽  
...  
Keyword(s):  
Drug Loading ◽  
Loading Capacity ◽  
High Drug ◽  
Dual Responsive ◽  
Mesoporous Organosilica ◽  
High Drug Loading

scholarly journals Development of In Situ Self-Assembly Nanoparticles to Encapsulate Lopinavir and Ritonavir for Long-Acting Subcutaneous Injection

Pharmaceutics ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 904
Author(s):  
Irin Tanaudommongkon ◽  
Asama Tanaudommongkon ◽  
Xiaowei Dong
Keyword(s):  
Sustained Release ◽  
Trough Concentration ◽  
Self Assembly ◽  
Subcutaneous Injection ◽  
Drug Loading ◽  
Entrapment Efficiency ◽  
Long Acting

Most antiretroviral medications for human immunodeficiency virus treatment and prevention require high levels of patient adherence, such that medications need to be administered daily without missing doses. Here, a long-acting subcutaneous injection of lopinavir (LPV) in combination with ritonavir (RTV) using in situ self-assembly nanoparticles (ISNPs) was developed to potentially overcome adherence barriers. The ISNP approach can improve the pharmacokinetic profiles of the drugs. The ISNPs were characterized in terms of particle size, drug entrapment efficiency, drug loading, in vitro release study, and in vivo pharmacokinetic study. LPV/RTV ISNPs were 167.8 nm in size, with a polydispersity index of less than 0.35. The entrapment efficiency was over 98% for both LPV and RTV, with drug loadings of 25% LPV and 6.3% RTV. A slow release rate of LPV was observed at about 20% on day 5, followed by a sustained release beyond 14 days. RTV released faster than LPV in the first 5 days and slower than LPV thereafter. LPV trough concentration remained above 160 ng/mL and RTV trough concentration was above 50 ng/mL after 6 days with one subcutaneous injection. Overall, the ISNP-based LPV/RTV injection showed sustained release profiles in both in vitro and in vivo studies.

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