scholarly journals Lipid- and gut microbiota-modulating effects of graphene oxide nanoparticles in high-fat diet-induced hyperlipidemic mice

RSC Advances ◽  
2018 ◽  
Vol 8 (55) ◽  
pp. 31366-31371 ◽  
Author(s):  
Juan Li ◽  
Shengmei Yang ◽  
Jiaqi Yu ◽  
Rongli Cui ◽  
Ru Liu ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
High Fat Diet ◽  
Short Chain Fatty Acid ◽  
Chain Fatty Acid ◽  
Oxide Nanoparticles ◽  
Lipid Levels ◽  
High Fat ◽  
Liver Lipids ◽  
The Impact ◽  
Microbiota Structure

The impact of GO on blood/liver lipids and gut microbiota structure in high-fat diet (HFD)-induced hyperlipidemic mice was investigated. Oral administration of GO for 28 days remarkably decreased lipid levels in blood and liver and GO did not decrease the total number of gut bacteria but increased the relative abundance of short-chain fatty acid (SCFA)-producing bacteria.

scholarly journals Effect of glucoraphanin from broccoli seeds on lipid levels and gut microbiota in high-fat diet-fed mice

2020 ◽  
Vol 68 ◽  
pp. 103858
Author(s):  
Xinxing Xu ◽  
Mei Dai ◽  
Fei Lao ◽  
Fang Chen ◽  
Xiaosong Hu ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
High Fat Diet ◽  
Lipid Levels ◽  
High Fat

scholarly journals It’s the fiber, not the fat: Significant effects of dietary challenge on the gut microbiome

2019 ◽  
Author(s):  
Kathleen E. Morrison ◽  
Eldin Jašarević ◽  
Christopher D. Howard ◽  
Tracy L. Bale
Keyword(s):  
Body Weight ◽  
Gut Microbiota ◽  
Dietary Fat ◽  
Gut Microbiome ◽  
High Fat Diet ◽  
Body Weight Gain ◽  
Chow Diet ◽  
Soluble Fiber ◽  
High Fat ◽  
The Impact

AbstractBackgroundDietary effects on the gut microbiome has been shown to play a key role in the pathophysiology of behavioral dysregulation, inflammatory disorders, metabolic syndrome, and obesity. Often overlooked is that experimental diets vary significantly in the proportion and source of dietary fiber. Commonly, treatment comparisons are made between animals that are fed refined diets that lack soluble fiber and animals fed vivarium-provided chow diet that contain a rich source of soluble fiber. Despite the well-established role of soluble fiber on metabolism, immunity, and behavior via the gut microbiome, the extent to which measured outcomes may be driven by differences in dietary fiber is unclear. Further, the significant impact of sex and age in response to dietary challenge is likely important and should also be considered.ResultsWe compared the impact of transitioning young and aged male and female mice from a chow diet to a refined low soluble fiber diet on body weight and gut microbiota. Then, to determine the contribution of dietary fat, we examined the impact of transitioning a subset of animals from refined low fat to refined high fat diet. Serial tracking of body weights revealed that consumption of low fat or high fat refined diet increased body weight in young and aged adult male mice. Young adult females showed resistance to body weight gain, while high fat diet-fed aged females had significant body weight gain. Transition from a chow diet to low soluble fiber refined diet accounted for most of the variance in community structure and composition across all groups. This dietary transition was characterized by a loss of taxa within the phylum Bacteroidetes and a concurrent bloom of Clostridia and Proteobacteria in a sex- and age-specific manner. Most notably, no changes to gut microbiota community structure and composition were observed between mice consuming either low- or high-fat diet, suggesting that transition to the refined diet that lacks soluble fiber is the primary driver of gut microbiota alterations, with limited additional impact of dietary fat on gut microbiota.ConclusionCollectively, our results show that the choice of control diet has a significant impact on outcomes and interpretation related to body weight and gut microbiota. These data also have broad implications for rodent studies that draw comparisons between refined high fat diets and chow diets to examine dietary fat effects on metabolic, immune, behavioral, and neurobiological outcomes.

scholarly journals Simultaneous Intake of Euglena gracilis and Vegetables Exerts Synergistic Anti-Obesity and Anti-Inflammatory Effects by Modulating the Gut Microbiota in Diet-Induced Obese Mice

Nutrients ◽  
2019 ◽  
Vol 11 (1) ◽  
pp. 204 ◽  
Author(s):  
Ran Okouchi ◽  
Shuang E ◽  
Kazushi Yamamoto ◽  
Toshikuni Ota ◽  
Kentarou Seki ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Gut Microbiota ◽  
Dietary Fiber ◽  
Euglena Gracilis ◽  
Short Chain Fatty Acid ◽  
Chain Fatty Acid ◽  
Short Chain ◽  
Obese Mice ◽  
High Fat ◽  
Anti Inflammatory

We determined whether the anti-obesity effect provided by the consumption of Euglena gracilis (Euglena), which is rich in insoluble dietary fiber, could be enhanced by the co-consumption of vegetables with an abundance of soluble dietary fiber. Nine-week-old male C57BL/6J mice were divided into five groups as follows: group 1 received a normal diet, group 2 received a high-fat diet, and groups 3, 4, and 5 received high fat diets containing 0.3% paramylon, 1.0% Euglena, or 1.0% Euglena plus 0.3% vegetables (barley leaf, kale, and ashitaba), respectively. Mice were fed ad libitum until 18 weeks of age. Euglena intake significantly reduced visceral fat accumulation in obese mice, and co-consumption of vegetables enhanced this effect. Consumption of Euglena with vegetables reduced adipocyte area, suppressed the expression of genes related to fatty acid synthesis, upregulated genes related to adipocyte lipolysis, and suppressed serum markers of inflammation. Notably, we also observed an increase in the fraction of short-chain fatty acid-producing beneficial bacteria, a reduction in harmful bacteria that cause inflammation, and an increase in short-chain fatty acid production. Therefore, the co-consumption of vegetables enhanced the anti-obesity and anti-inflammatory effects of Euglena, likely by modulating the gut microbiota composition.

scholarly journals The impact of exercise training and resveratrol supplementation on gut microbiota composition in high-fat diet fed mice

2018 ◽  
Vol 6 (20) ◽  
pp. e13881 ◽  
Author(s):  
Nina Brandt ◽  
Dorota Kotowska ◽  
Caroline M. Kristensen ◽  
Jesper Olesen ◽  
Ditte O. Lützhøft ◽  
...  
Keyword(s):  
Exercise Training ◽  
Gut Microbiota ◽  
High Fat Diet ◽  
Microbiota Composition ◽  
High Fat ◽  
The Impact ◽  
Gut Microbiota Composition

scholarly journals Butyrate reduces high-fat diet-induced metabolic alterations, hepatic steatosis and pancreatic beta cell and intestinal barrier dysfunctions in prediabetic mice

2017 ◽  
Vol 242 (12) ◽  
pp. 1214-1226 ◽  
Author(s):  
VA Matheus ◽  
LCS Monteiro ◽  
RB Oliveira ◽  
DA Maschio ◽  
CB Collares-Buzato
Keyword(s):  
Fatty Acid ◽  
High Fat Diet ◽  
Short Chain Fatty Acid ◽  
Chain Fatty Acid ◽  
Short Chain ◽  
Intestinal Epithelial ◽  
High Fat ◽  
Intestinal Epithelial Barrier ◽  
Body Adiposity

In this study, we investigated the effect of diet supplementation with sodium butyrate (5% w/w), a short-chain fatty acid produced by the intestinal microbiota, on metabolic parameters, body adiposity, hepatic and pancreatic lipid accumulation, beta cell function/mass as well as on the structure and function of the tight junction-mediated intestinal epithelial barrier in both normal and obese/prediabetic C57 mice fed a regular (control) or high-fat diet for 60 days, respectively. Butyrate treatment significantly inhibited all the high-fat-induced metabolic dysfunctions evaluated, i.e. significantly reduced the weight gain and body adiposity as well as the insulin resistant state, hyperglycemia and hyperinsulinemia, without changing food intake. In addition, high-fat-fed mice treated with this short-chain fatty acid displayed no compensatory hyperplasia of pancreatic beta cells nor marked hepatic steatosis as seen in prediabetic mice after high-fat diet only. Isolated pancreatic islets from high-fat-fed mice treated with butyrate showed improvement of the insulin secretion, which was associated with a significant decrease in lipid accumulation within the pancreas. Butyrate enhanced the intestinal epithelial barrier, as revealed by the FITC-Dextran permeability assay, which was accompanied by a significant increase in the junctional content of the tight junction-associated claudin-1 in intestinal epithelia of jejunum, ileum, and colon of both control and high-fat mice. In conclusion, our results showed that diet supplementation with butyrate inhibits the deleterious effects of high-fat diet intake on metabolic parameters and structure/function of several tissues/organs associated with type 2 diabetes mellitus in a mouse model, suggesting a potential use of this short-chain fatty acid in the treatment of this endocrine-metabolic disorder. Impact statement Butyrate is a short-chain fatty acid produced by the intestinal microbiota through the fermentation of non-absorbable carbohydrates and proteins (e.g. fibers). Sodium butyrate incorporated into the diet displayed a protective action on metabolic, hepatic, pancreatic and intestinal alterations induced by high-fat diet in mice, resulting in significant inhibition of the development of a prediabetic state. Thus, our data suggest that butyrate may have a potential therapeutic use in the treatment of type 2 diabetes and related disorders.

scholarly journals Depletion of the gut microbiota differentially affects the impact of whey protein on high‐fat diet‐induced obesity and intestinal permeability

2021 ◽  
Vol 9 (11) ◽  
Author(s):  
Serena Boscaini ◽  
Raul Cabrera‐Rubio ◽  
Anna Golubeva ◽  
Oleksandr Nychyk ◽  
Christine Fülling ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Whey Protein ◽  
Intestinal Permeability ◽  
High Fat Diet ◽  
High Fat ◽  
Diet Induced Obesity ◽  
The Impact

scholarly journals Mango Supplementation Modulates Gut Microbial Dysbiosis and Short-Chain Fatty Acid Production Independent of Body Weight Reduction in C57BL/6 Mice Fed a High-Fat Diet

2016 ◽  
Vol 146 (8) ◽  
pp. 1483-1491 ◽  
Author(s):  
Babajide Ojo ◽  
Guadalupe Davila El-Rassi ◽  
Mark E Payton ◽  
Penelope Perkins-Veazie ◽  
Stephen Clarke ◽  
...  
Keyword(s):  
Body Weight ◽  
Fatty Acid ◽  
Weight Reduction ◽  
High Fat Diet ◽  
Short Chain Fatty Acid ◽  
Chain Fatty Acid ◽  
High Fat ◽  
Fatty Acid Production ◽  
Body Weight Reduction ◽  
Microbial Dysbiosis
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