scholarly journals The enhanced osteogenesis and osteointegration of 3-DP PCL scaffolds via structural and functional optimization using collagen networks

RSC Advances ◽  
2018 ◽  
Vol 8 (56) ◽  
pp. 32304-32316 ◽  
Author(s):  
Jinbing Wang ◽  
Chucheng Lin ◽  
Xin Gao ◽  
Zhiwei Zheng ◽  
Mimgming Lv ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Biological Activity ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Mechanical Stability ◽  
Scaffold Design ◽  
Engineering Applications ◽  
Functional Optimization ◽  
Optimal Balance

Optimal balance between biological activity and mechanical stability should be meticulously considered during scaffold design for bone tissue engineering applications.

scholarly journals A Proposed Fabrication Method of Novel PCL-GEL-HAp Nanocomposite Scaffolds for Bone Tissue Engineering Applications

2010 ◽  
Vol 19 (4) ◽  
pp. 096369351001900 ◽  
Author(s):  
A. Hamlekhan ◽  
M. Mozafari ◽  
N. Nezafati ◽  
M. Azami ◽  
H. Hadipour
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Mechanical Test ◽  
Fibroblast Cell ◽  
Mouse Fibroblast ◽  
Fabrication Method ◽  
Engineering Applications ◽  
Poly Caprolactone

In this study, poly(∊-caprolactone) (PCL), gelatin (GEL) and nanocrystalline hydroxyapatite (HAp) was applied to fabricate novel PCL-GEL-HAp nanaocomposite scaffolds through a new fabrication method. With the aim of finding the best fabrication method, after testing different methods and solvents, the best method and solvents were found, and the nanocomposites were prepared through layer solvent casting combined with freeze-drying. Acetone and distillated water were used as the PCL and GEL solvents, respectively. The mechanical test showed that the increasing of the PCL weight through the scaffolds caused the improvement of the final nanocomposite mechanical behavior due to the increasing of the ultimate stress, stiffness and elastic modulus (8 MPa for 0% wt PCL to 23.5 MPa for 50% wt PCL). The biomineralization investigation of the scaffolds revealed the formation of bone-like apatite layers after immersion in simulated body fluid (SBF). In addition, the in vitro cytotoxity of the scaffolds using L929 mouse fibroblast cell line (ATCC) indicated no sign of toxicity. These results indicated that the fabricated scaffold possesses the prerequisites for bone tissue engineering applications.

Multiferroic Reinforced Bioactive Glass Composites for Bone Tissue Engineering Applications

2018 ◽  
Vol 20 (12) ◽  
pp. 1800329 ◽  
Author(s):  
Chandra Khatua ◽  
Dipten Bhattacharya ◽  
Biswanath Kundu ◽  
Vamsi Krishna Balla ◽  
Subhadip Bodhak ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bioactive Glass ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Engineering Applications ◽  
Glass Composites
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