scholarly journals Novel encapsulation of water soluble inorganic or organic ingredients in melamine formaldehyde microcapsules to achieve their sustained release in an aqueous environment

RSC Advances ◽  
2018 ◽  
Vol 8 (52) ◽  
pp. 29495-29498 ◽  
Author(s):  
Cong Sui ◽  
Jon A. Preece ◽  
Shu-Hong Yu ◽  
Zhibing Zhang
Keyword(s):  
Sustained Release ◽  
Potassium Chloride ◽  
Water Soluble ◽  
Aqueous Environment ◽  
Melamine Formaldehyde ◽  
Allura Red ◽  
Red Dye

A novel type of melamine formaldehyde microcapsule has been used to encapsulate water-soluble ingredients: potassium chloride (KCl) and allura red (dye), which achieved a sustained release for 12 h and 10 days in aqueous environment respectively.

scholarly journals Novel polystyrene sulfonate–silica microspheres as a carrier of a water soluble inorganic salt (KCl) for its sustained release, via a dual-release mechanism

RSC Advances ◽  
2017 ◽  
Vol 7 (1) ◽  
pp. 478-481 ◽  
Author(s):  
Cong Sui ◽  
Jon A. Preece ◽  
Zhibing Zhang
Keyword(s):  
Sustained Release ◽  
Potassium Chloride ◽  
Inorganic Salt ◽  
Water Soluble ◽  
Release Mechanism ◽  
Aqueous Environment ◽  
Polystyrene Sulfonate ◽  
Silica Microspheres ◽  
Dual Release

Polystyrene sulfonate and silica microspheres with potassium chloride encapsulated show a dual-release mechanism of K+ in an aqueous environment.

Formulation Optimization of Sustained Release Resinate Microcapsules of Tramadol Hydrochloride by Using 3/2 Factorial Design

2017 ◽  
Vol 6 (2) ◽  
pp. 57
Author(s):  
Kamble Ravindra K. ◽  
Chauhan Chetan S. ◽  
Kamble Priyadarshani R. ◽  
Naruka Pushpendra S.
Keyword(s):  
Drug Delivery ◽  
Ion Exchange ◽  
Sustained Release ◽  
Factorial Design ◽  
Linear Regression Analysis ◽  
Extended Period ◽  
Multiple Linear Regression Analysis ◽  
Water Soluble ◽  
Tramadol Hydrochloride ◽  
Release Drug

The main aim of the present work was to develop the microcapsules of tramadol hydrochloride for the oral sustained release drug delivery. Tramadol hydrochloride a BCS class I drug a centrally acting synthetic analgesic was complexed with Indion 254 ion exchange resin. The microcapsules were prepared by encapsulating the prepared resinates by o/o solvent evaporation technique. In the investigation 32 full factorial design was used to investigate the joint influence of two formulation variable amount of eudragit RS 100 and plasticized PEG 400. The results of multiple linear regression analysis indicated that for obtaining a sustained release drug delivery the optimum concentrations of both the plasticizer and coating solution to be used. The factorial models were used to prepare optimized microcapsules and optimized formulations showed sustained release profiles for the extended period of more than 12 hrs. From the present investigations concluded that resinate microcapsules of highly water soluble drug can provide controlled release of drug for extended period.Key Words: Tramadol hydrochloride, ion exchange resinate, microcapsules, sustained release

Compritol®888 ATO a Lipid Excipient for Sustained Release of Highly Water Soluble Active: Formulation, Scale-up and IVIVC Study

2013 ◽  
Vol 10 (5) ◽  
pp. 548-556 ◽  
Author(s):  
Shilpa Patere ◽  
Neha Desai ◽  
Ankitkumar Jain ◽  
Prashant Kadam ◽  
Urmila Thatte ◽  
...  
Keyword(s):  
Sustained Release ◽  
Scale Up ◽  
Water Soluble ◽  
Active Formulation

Direct photoreactive immobilization of water-soluble phospholipid polymers on substrates in an aqueous environment

2021 ◽  
Vol 199 ◽  
pp. 111507
Author(s):  
Kyoko Fukazawa ◽  
Kazushi Tsuji ◽  
Yuuki Inoue ◽  
Kazuhiko Ishihara
Keyword(s):  
Water Soluble ◽  
Aqueous Environment

scholarly journals Interactions between 4-thiothymidine and water-soluble cyclodextrins: Evidence for supramolecular structures in aqueous solutions

2016 ◽  
Vol 12 ◽  
pp. 549-563 ◽  
Author(s):  
Vito Rizzi ◽  
Sergio Matera ◽  
Paola Semeraro ◽  
Paola Fini ◽  
Pinalysa Cosma
Keyword(s):  
Inclusion Complexes ◽  
Pyrimidine Ring ◽  
Protective Role ◽  
Supramolecular Structures ◽  
Water Soluble ◽  
Aqueous Environment ◽  
Spectroscopic Techniques ◽  
Guest Molecules ◽  
H Nmr ◽  
Cv Measurements

Since several years the inclusion of organic compounds (guests) within the hydrophobic cavity (host) of cyclodextrins (CDs) has been the subject of many investigations. Interestingly, the formation of inclusion complexes could affect the properties of the guest molecules and, for example, the influence of the delivery system can be a method to improve/change the photochemical behavior of the guest. In particular, very recent studies have shown the protective role of CDs preventing the degradation of the encapsulated guest. Starting from this consideration, in this work, only the structure and complexation mode of the inclusion complexes involving 4-thiothymidine (S4TdR, a known photosensitizer) and five CDs, namely 2-hydroxypropyl-α-cyclodextrin (2-HP-α-CD), 2-hydroxypropyl-β-cyclodextrin (2-HP-β-CD), 2-hydroxypropyl-γ-cyclodextrin (2-HP-γ-CD), heptakis-(2,6-di-O-methyl)-β-cyclodextrin (DIMEB CD) and heptakis-(2,3,6-tri-O-methyl)-β-cyclodextrin (TRIMEB CD) were investigated by different spectroscopic techniques (UV–vis, FTIR–ATR, 1H NMR) and cyclic voltammetry analysis (CV). This work is necessary for a prospective research on the photoreactivity of S4TdR in aqueous environment and in the presence of CDs to prevent its degradation under irradiation. UV–vis, FTIR–ATR and CV measurements suggested the formation of supramolecular structures involving the employed CDs and mainly the pyrimidine ring of S4TdR. 1H NMR analyses confirmed such indication, unveiling the presence of inclusion complexes. The strongest and deepest interactions were suggested when TRIMEB and DIMEB CDs were studied. The S4TdR affinity towards CDs was also evaluated by using the Benesi–Hildebrand (B–H) equation at 25 °C employing CV and 1H NMR methods. The stoichiometry of the interaction was also inferred and it appears to be 1:1 for all examined CDs.

scholarly journals Nanocharacterization of liposomes for the encapsulation of water soluble compounds from Cordyceps sinensis CS1197 by a supercritical gas anti-solvent technique

RSC Advances ◽  
2018 ◽  
Vol 8 (60) ◽  
pp. 34634-34649 ◽  
Author(s):  
G. M. Shashidhar ◽  
B. Manohar
Keyword(s):  
Sustained Release ◽  
Tween 80 ◽  
Water Soluble ◽  
Cordyceps Sinensis

Nano-liposomes were designed for the sustained release of water soluble compounds from C. sinensis CS1197 using a supercritical gas anti-solvent (SC-GAS) method at various pressures, temperatures and Tween 80 concentrations.

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