scholarly journals Low molecular weight galactomannans-based standardized fenugreek seed extract ameliorates high-fat diet-induced obesity in miceviamodulation of FASn, IL-6, leptin, and TRIP-Br2

RSC Advances ◽  
2018 ◽  
Vol 8 (57) ◽  
pp. 32401-32416 ◽  
Author(s):  
Amit D. Kandhare ◽  
Debasish Bandyopadhyay ◽  
Prasad A. Thakurdesai
Keyword(s):  
Molecular Weight ◽  
High Fat Diet ◽  
Metabolic Disorder ◽  
Seed Extract ◽  
Low Molecular Weight ◽  
High Fat ◽  
Fenugreek Seed ◽  
Diet Induced Obesity ◽  
The World

Obesity is a complex, chronic metabolic disorder and its prevalence is increasing throughout most of the world.

scholarly journals Anti-obesity potential of Moringa olifera seed extract and lycopene on high fat diet induced obesity in male Sprauge Dawely rats

2020 ◽  
Vol 27 (10) ◽  
pp. 2733-2746
Author(s):  
Omnia E. Kilany ◽  
Heba M.A. Abdelrazek ◽  
Tahany Saleh Aldayel ◽  
Shimaa Abdo ◽  
Manal M.A. Mahmoud
Keyword(s):  
High Fat Diet ◽  
Seed Extract ◽  
High Fat ◽  
Diet Induced Obesity

Therapeutic effects of açaí seed extract on hepatic steatosis in high‐fat diet‐induced obesity in male mice: a comparative effect with rosuvastatin

2020 ◽  
Vol 72 (12) ◽  
pp. 1921-1932
Author(s):  
Thamires Barros Tavares ◽  
Izabelle Barcellos Santos ◽  
Graziele Freitas Bem ◽  
Dayane Teixeira Ognibene ◽  
Ana Paula Machado Rocha ◽  
...  
Keyword(s):  
Hepatic Steatosis ◽  
High Fat Diet ◽  
Seed Extract ◽  
Therapeutic Effects ◽  
Male Mice ◽  
High Fat ◽  
Comparative Effect ◽  
Diet Induced Obesity

scholarly journals Antihyperglycemic and antihyperlipidemic effects of low-molecular-weight carrageenan in rats

2018 ◽  
Vol 13 (1) ◽  
pp. 379-384 ◽  
Author(s):  
Xia Qiu ◽  
Wenwen Zhong
Keyword(s):  
Molecular Weight ◽  
Body Weight ◽  
Blood Glucose ◽  
High Fat Diet ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Postprandial Blood Glucose ◽  
Control Group ◽  
Low Molecular Weight ◽  
High Fat

AbstractThis study investigated the antihyperglycemic and antihyperlipidemic effects of low-molecular-weight carrageenan (LC) on rats fed a high-fat diet. Wistar rats were divided into five groups: normal control group (NC), high-fat diet control group (HC), carrageenan-treated control group (CC), 1% LC group (1% LC), and 3% LC-groups (3% LC). Body weight, food intake, fecal weight, blood glucose, and serum lipid levels were measured. After 30 days, body weight significantly decreased in the LC-treated groups than in the HC group. Moreover, in the LC-treated groups, postprandial blood glucose, total cholesterol, triglyceride, and low-density lipoprotein cholesterol (LDL-C) levels decreased, whereas high-density lipoprotein cholesterol (HDL-C) levels increased. From this study, our data suggest that LC has antihyperglycemic and hypolipidemic effects when compared to carrageenan, likely related to its increased absorption due to its lower molecular weight.

scholarly journals Effects of Fenugreek Seed Extract in Obese Mice Fed a High-Fat Diet

2005 ◽  
Vol 69 (6) ◽  
pp. 1186-1188 ◽  
Author(s):  
Toshiaki HANDA ◽  
Kohji YAMAGUCHI ◽  
Yoshikatsu SONO ◽  
Kazunaga YAZAWA
Keyword(s):  
High Fat Diet ◽  
Seed Extract ◽  
Obese Mice ◽  
High Fat ◽  
Fenugreek Seed

Low molecular weight chitosan oligosaccharides (LMW-COSs) prevent obesity-related metabolic abnormalities in association with the modification of gut microbiota in high-fat diet (HFD)-fed mice

2020 ◽  
Vol 11 (11) ◽  
pp. 9947-9959
Author(s):  
Ningning He ◽  
Shuo Wang ◽  
Zhiyuan Lv ◽  
Wandong Zhao ◽  
Shangyong Li
Keyword(s):  
Molecular Weight ◽  
Inflammatory Response ◽  
Gut Microbiota ◽  
High Fat Diet ◽  
Metabolic Parameters ◽  
Low Molecular Weight ◽  
Metabolic Abnormalities ◽  
High Fat ◽  
Chitosan Oligosaccharides ◽  
Low Molecular Weight Chitosan

Enzymatic LMW-COSs ameliorate obesity and obesity-related metabolic abnormalities. The overall change in gut microbiota was associated with metabolic parameters and its prebiotic functions by regulating gut microbiota and inflammatory response.

scholarly journals Extraction and Hypolipidemic Activity of Low Molecular Weight Polysaccharides Isolated from Rosa Laevigata Fruits

2020 ◽  
Vol 2020 ◽  
pp. 1-20
Author(s):  
Xuejiao Zhang ◽  
Yihong Hu ◽  
Chenzhong Jin ◽  
Weiguo Wu
Keyword(s):  
Oxidative Stress ◽  
Molecular Weight ◽  
Stress Responses ◽  
High Fat Diet ◽  
Raw Material ◽  
Low Molecular Weight ◽  
Peroxisome Proliferator ◽  
Extraction Temperature ◽  
High Fat ◽  
Chinese Medicinal Herb

Three novel low molecular weight polysaccharides (RLP-1a, RLP-2a, and RLP-3a) with 9004, 8761, and 7571 Da were first obtained by purifying the crude polysaccharides from the fruits of a traditional Chinese medicinal herb Rosae Laevigatae. The conditions for polysaccharides from the R. Laevigatae fruit (RLP) extraction were optimized by the response surface methodology, and the optimal conditions were as follows: extraction temperature, 93°C; extraction time, 2.8 h; water to raw material ratio, 22; extraction frequency, 3. Structural characterization showed that RLP-1a consisted of rhamnose, arabinose, xylose, glucose, and galactose with the ratio of 3.14 : 8.21 : 1 : 1.37 : 4.90, whereas RLP-2a was composed of rhamnose, mannose, glucose, and galactose with the ratio of 1.70 : 1 : 93.59 : 2.73, and RLP-3a was composed of rhamnose, arabinose, xylose, mannose, glucose, and galactose with the ratio of 6.04 : 26.51 : 2.05 : 1 : 3.17 : 31.77. The NMR analyses revealed that RLP-1a, RLP-2a, and RLP-3a contained 6, 4, and 6 types of glycosidic linkages, respectively. RLP-1a and RLP-3a exhibited distinct antioxidant abilities on the superoxide anions, 1,1-diphenyl-2-picrylhydrazyl (DPPH), and hydroxyl radicals in vitro. RLPs could decrease the serum lipid levels, elevate the serum high-density lipoprotein cholesterol levels, enhance the antioxidant enzymes levels, and upregulate of FADS2, ACOX3, and SCD-1 which involved in the lipid metabolic processes and oxidative stress in the high-fat diet-induced rats. These results suggested that RLPs ameliorated the high-fat diet- (HFD-) induced lipid metabolism disturbance in the rat liver through the peroxisome proliferator-activated receptor (PPAR) signaling pathway. Low molecular weight polysaccharides of RLP could be served as a novel potential functional food for improving hyperlipidemia and liver oxidative stress responses.

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