scholarly journals Scope and advances in the catalytic propargylic substitution reaction

RSC Advances ◽  
2018 ◽  
Vol 8 (54) ◽  
pp. 31129-31193 ◽  
Author(s):  
Rashmi Roy ◽  
Satyajit Saha
Keyword(s):  
Substitution Reaction ◽  
Nucleophilic Displacement ◽  
Propargylic Alcohol ◽  
Recent Developments ◽  
Current Scenario ◽  
Propargylic Substitution

Direct nucleophilic displacement of the alpha-hydroxy of the propargylic alcohol is one of the sought-after methods in the current scenario. An updated summary of the recent developments in this field is presented here.

Propargylic Substitution Reaction Catalyzed by Group IV (Ti, Zr, Hf)–Ru Heterobimetallic Complexes

2011 ◽  
Vol 30 (11) ◽  
pp. 3194-3199 ◽  
Author(s):  
Takamasa Miyazaki ◽  
Yoshiaki Tanabe ◽  
Masahiro Yuki ◽  
Yoshihiro Miyake ◽  
Yoshiaki Nishibayashi
Keyword(s):  
Substitution Reaction ◽  
Group Iv ◽  
Heterobimetallic Complexes ◽  
Propargylic Substitution

scholarly journals Emerging novel coronavirus (2019-nCoV)—current scenario, evolutionary perspective based on genome analysis and recent developments

2020 ◽  
Vol 40 (1) ◽  
pp. 68-76 ◽  
Author(s):  
Yashpal Singh Malik ◽  
Shubhankar Sircar ◽  
Sudipta Bhat ◽  
Khan Sharun ◽  
Kuldeep Dhama ◽  
...  
Keyword(s):  
Genome Analysis ◽  
Evolutionary Perspective ◽  
Recent Developments ◽  
Current Scenario ◽  
Novel Coronavirus

scholarly journals Therapies for Type 1 Diabetes: Current Scenario and Future Perspectives

2019 ◽  
Vol 12 ◽  
pp. 117955141984452 ◽  
Author(s):  
Varun Pathak ◽  
Nupur Madhur Pathak ◽  
Christina L O’Neill ◽  
Jasenka Guduric-Fuchs ◽  
Reinhold J Medina
Keyword(s):  
Type 1 Diabetes ◽  
Islet Cells ◽  
Standard Of Care ◽  
Current Standard ◽  
Post Transplantation ◽  
Prediction And Prevention ◽  
Recent Developments ◽  
Current Scenario ◽  
Long Acting

Type 1 diabetes (T1D) is caused by autoimmune destruction of insulin-producing β cells located in the endocrine pancreas in areas known as islets of Langerhans. The current standard-of-care for T1D is exogenous insulin replacement therapy. Recent developments in this field include the hybrid closed-loop system for regulated insulin delivery and long-acting insulins. Clinical studies on prediction and prevention of diabetes-associated complications have demonstrated the importance of early treatment and glucose control for reducing the risk of developing diabetic complications. Transplantation of primary islets offers an effective approach for treating patients with T1D. However, this strategy is hampered by challenges such as the limited availability of islets, extensive death of islet cells, and poor vascular engraftment of islets post-transplantation. Accordingly, there are considerable efforts currently underway for enhancing islet transplantation efficiency by harnessing the beneficial actions of stem cells. This review will provide an overview of currently available therapeutic options for T1D, and discuss the growing evidence that supports the use of stem cell approaches to enhance therapeutic outcomes.

Ruthenium catalysts for selective nucleophilic allylic substitution

2008 ◽  
Vol 80 (5) ◽  
pp. 861-871 ◽  
Author(s):  
Christian Bruneau ◽  
Jean-Luc Renaud ◽  
Bernard Demerseman
Keyword(s):  
Substitution Reaction ◽  
Oxidative Addition ◽  
Ruthenium Catalysts ◽  
Allylic Substitution ◽  
Subsequent Reaction ◽  
Enantioselective Reactions ◽  
Recent Developments

Recent developments in the chemistry of η3-allylruthenium(IV) complexes are due to their straightforward synthesis resulting from oxidative addition of allylic substrates to a ruthenium(II) center. Subsequent reaction with a nucleophile is the basis of their involvement in the catalytic allylic substitution reaction. We focus here on ruthenium-catalyzed substitution of allylic substrates by C-, N-, and O-nucleophiles and show that selected ligands make regio- and enantioselective reactions possible.

BiCl3-Catalyzed propargylic substitution reaction of propargylic alcohols with C-, O-, S- and N-centered nucleophiles

2006 ◽  
pp. 3352 ◽  
Author(s):  
Zhuang-ping Zhan ◽  
Wen-zhen Yang ◽  
Rui-feng Yang ◽  
Jing-liang Yu ◽  
Jun-ping Li ◽  
...  
Keyword(s):  
Substitution Reaction ◽  
Propargylic Alcohols ◽  
Propargylic Substitution

BiCl3-Catalyzed Propargylic Substitution Reaction of Propargylic Alcohols with C-, O-, S- and N-Centered Nucleophiles.

ChemInform ◽  
2006 ◽  
Vol 37 (52) ◽  
Author(s):  
Zhuang-ping Zhan ◽  
Wen-zhen Yang ◽  
Rui-feng Yang ◽  
Jing-liang Yu ◽  
Jun-ping Li ◽  
...  
Keyword(s):  
Substitution Reaction ◽  
Propargylic Alcohols ◽  
Propargylic Substitution
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