scholarly journals Ameliorative effect of biofabricated ZnO nanoparticles ofTrianthema portulacastrumLinn. on dermal woundsviaremoval of oxidative stress and inflammation

RSC Advances ◽  
2018 ◽  
Vol 8 (38) ◽  
pp. 21621-21635 ◽  
Author(s):  
Ekta Yadav ◽  
Deepika Singh ◽  
Pankajkumar Yadav ◽  
Amita Verma
Keyword(s):  
Oxidative Stress ◽  
Wound Healing ◽  
Zinc Oxide ◽  
Zno Nanoparticles ◽  
Ameliorative Effect

The curative efficacy of a green synthesized zinc oxide nano-ointment on wound healing was investigated.

scholarly journals Antibacterial Activity and Mechanism of Action of Zinc Oxide Nanoparticles againstCampylobacter jejuni

2011 ◽  
Vol 77 (7) ◽  
pp. 2325-2331 ◽  
Author(s):  
Yanping Xie ◽  
Yiping He ◽  
Peter L. Irwin ◽  
Tony Jin ◽  
Xianming Shi
Keyword(s):  
Oxidative Stress ◽  
Zinc Oxide ◽  
Stress Response ◽  
Quantitative Pcr ◽  
Zno Nanoparticles ◽  
Morphological Changes ◽  
Toxin Production ◽  
Response To Treatment ◽  
Large Set ◽  
Zno Nanoparticle

ABSTRACTThe antibacterial effect of zinc oxide (ZnO) nanoparticles onCampylobacter jejuniwas investigated for inhibition and inactivation of cell growth. The results showed thatC. jejuniwas extremely sensitive to treatment with ZnO nanoparticles. The MIC of ZnO nanoparticles forC. jejuniwas determined to be 0.05 to 0.025 mg/ml, which is 8- to 16-fold lower than that forSalmonella entericaserovar Enteritidis andEscherichia coliO157:H7 (0.4 mg/ml). The action of ZnO nanoparticles againstC. jejuniwas determined to be bactericidal, not bacteriostatic. Scanning electron microscopy examination revealed that the majority of the cells transformed from spiral shapes into coccoid forms after exposure to 0.5 mg/ml of ZnO nanoparticles for 16 h, which is consistent with the morphological changes ofC. jejuniunder other stress conditions. These coccoid cells were found by ethidium monoazide-quantitative PCR (EMA-qPCR) to have a certain level of membrane leakage. To address the molecular basis of ZnO nanoparticle action, a large set of genes involved in cell stress response, motility, pathogenesis, and toxin production were selected for a gene expression study. Reverse transcription-quantitative PCR (RT-qPCR) showed that in response to treatment with ZnO nanoparticles, the expression levels of two oxidative stress genes (katAandahpC) and a general stress response gene (dnaK) were increased 52-, 7-, and 17-fold, respectively. These results suggest that the antibacterial mechanism of ZnO nanoparticles is most likely due to disruption of the cell membrane and oxidative stress inCampylobacter.

scholarly journals Green Synthesized Zinc Oxide (ZnO) Nanoparticles Induce Oxidative Stress and DNA Damage in Lathyrus sativus L. Root Bioassay System

Antioxidants ◽  
2017 ◽  
Vol 6 (2) ◽  
pp. 35 ◽  
Author(s):  
Kamal Panda ◽  
Dambaru Golari ◽  
A. Venugopal ◽  
V. Achary ◽  
Ganngam Phaomei ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Zinc Oxide ◽  
Zno Nanoparticles ◽  
Lathyrus Sativus ◽  
Bioassay System ◽  
Root Bioassay ◽  
Lathyrus Sativus L

Toxicity of zinc oxide (ZnO) nanoparticles on human bronchial epithelial cells (BEAS-2B) is accentuated by oxidative stress

2010 ◽  
Vol 48 (6) ◽  
pp. 1762-1766 ◽  
Author(s):  
Boon Chin Heng ◽  
Xinxin Zhao ◽  
Sijing Xiong ◽  
Kee Woei Ng ◽  
Freddy Yin-Chiang Boey ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Zinc Oxide ◽  
Epithelial Cells ◽  
Zno Nanoparticles ◽  
Bronchial Epithelial Cells ◽  
Human Bronchial Epithelial Cells ◽  
Bronchial Epithelial

scholarly journals Sodium Alginate-Zinc Oxide Nanocomposite Film for Antibacterial Wound Healing Applications

2020 ◽  
Vol 10 (5) ◽  
pp. 6245-6252
Keyword(s):  
Wound Healing ◽  
Zinc Oxide ◽  
Sodium Alginate ◽  
Zno Nanoparticles ◽  
Film Surface ◽  
Antibacterial Activities ◽  
Zno Nanoparticle ◽  
Force Microscopy ◽  
Atomic Force ◽  
Ft Ir

This study aims to develop sodium alginate (SA) based ZnO nanoparticles as antibacterial film for wound healing applications. As natural materials, sodium alginate has been widely investigated and used in wound healing. The ZnO nanoparticles were incorporated as antibacterial into sodium alginate with different compositions (2, 4, 6, 8, 10 ml). Solvent casting method was performed to prepare a film. The film was characterized by using Fourier Transform Infrared Spectroscopy (FT-IR), Atomic Force Microscopy (AFM) and Field Emission Scanning Electron Microscopy (FESEM). Effectiveness of antibacterial activity was carried out against Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) to characterize the sample. The results from microstructure analysis indicated that as ZnO nanoparticle compositions increased, the film surface became rough. It was found that sodium alginate incorporated with ZnO had slightly higher antibacterial activities against S. aureus than E. coli. Thus, sodium alginate (SA)-Zinc oxide (ZnO) nanoparticle has the potential to be used as a wound healing material in biomedical applications.

scholarly journals Wound Healing Composite Materials of Bacterial Cellulose and Zinc Oxide Nanoparticles with Immobilized Betulin Diphosphate

Nanomaterials ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 713
Author(s):  
Nina Melnikova ◽  
Alexander Knyazev ◽  
Viktor Nikolskiy ◽  
Peter Peretyagin ◽  
Kseniia Belyaeva ◽  
...  
Keyword(s):  
Wound Healing ◽  
Zinc Oxide ◽  
Bacterial Cellulose ◽  
Zinc Oxide Nanoparticles ◽  
Wound Dressings ◽  
Oxide Nanoparticles ◽  
Burn Wound ◽  
Zno Nps ◽  
Wound Model ◽  
And Oxidative Stress

A design of new nanocomposites of bacterial cellulose (BC) and betulin diphosphate (BDP) pre-impregnated into the surface of zinc oxide nanoparticles (ZnO NPs) for the production of wound dressings is proposed. The sizes of crystalline BC and ZnO NPs (5–25%) corresponded to 5–6 nm and 10–18 nm, respectively (powder X-ray diffractometry (PXRD), Fourier-infrared (FTIR), ultraviolet (UV), atomic absorption (AAS) and photoluminescence (PL) spectroscopies). The biological activity of the wound dressings “BC-ZnO NPs-BDP” was investigated in rats using a burn wound model. Morpho-histological studies have shown that more intensive healing was observed during treatment with hydrophilic nanocomposites than the oleophilic standard (ZnO NPs-BDP oleogel; p < 0.001). Treatment by both hydrophilic and lipophilic agents led to increases in antioxidant enzyme activity (superoxide dismutase (SOD), catalase) in erythrocytes and decreases in the malondialdehyde (MDA) concentration by 7, 10 and 21 days (p < 0.001). The microcirculation index was restored on the 3rd day after burn under treatment with BC-ZnO NPs-BDP wound dressings. The results of effective wound healing with BC-ZnO NPs-BDP nanocomposites can be explained by the synergistic effect of all nanocomposite components, which regulate oxygenation and microcirculation, reducing hypoxia and oxidative stress in a burn wound.

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