scholarly journals A pH and magnetic dual-response hydrogel for synergistic chemo-magnetic hyperthermia tumor therapy

RSC Advances ◽  
2018 ◽  
Vol 8 (18) ◽  
pp. 9812-9821 ◽  
Author(s):  
Xiaohan Zhou ◽  
Longchen Wang ◽  
Yanjun Xu ◽  
Wenxian Du ◽  
Xiaojun Cai ◽  
...  
Keyword(s):  
Tumor Therapy ◽  
Magnetic Hyperthermia ◽  
Dual Responsive ◽  
Dual Response ◽  
Highly Sensitive

A pH and magnetic dual-responsive hydrogel highly sensitive to tumor acid microenvironment and efficient responsive magnetic-hyperthermia cancer eradication.

scholarly journals Highly efficient magnetic hyperthermia ablation of tumors using injectable polymethylmethacrylate–Fe3O4

RSC Advances ◽  
2017 ◽  
Vol 7 (5) ◽  
pp. 2913-2918 ◽  
Author(s):  
Yi Ling ◽  
Xiuzhen Tang ◽  
Fengjuan Wang ◽  
Xiaohan Zhou ◽  
Ronghui Wang ◽  
...  
Keyword(s):  
Minimally Invasive ◽  
Tumor Therapy ◽  
Magnetic Hyperthermia ◽  
Minimally Invasive Technique ◽  
Invasive Technique ◽  
Highly Efficient

Magnetic hyperthermia is a promising minimally invasive technique for tumor therapy which has drawn much attention.

scholarly journals Reactive oxygen species and enzyme dual-responsive biocompatible drug delivery system for targeted tumor therapy

2020 ◽  
Vol 324 ◽  
pp. 330-340 ◽  
Author(s):  
Ning Zhao ◽  
Bingbing Ding ◽  
Ying Zhang ◽  
Jessica L. Klockow ◽  
Ken Lau ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Tumor Therapy ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Dual Responsive

GSH/pH dual-responsive supramolecular hybrid vesicles for synergistic enzymatic/chemo-tumor therapy

2020 ◽  
Vol 18 ◽  
pp. 100458 ◽  
Author(s):  
Jianping He ◽  
Jianzhuang Chen ◽  
Dechao Niu ◽  
Xiaobo Jia ◽  
Qinghua Wang ◽  
...  
Keyword(s):  
Tumor Therapy ◽  
Dual Responsive

Fabrication of dual responsive co-delivery system based on three-armed peptides for tumor therapy

Biomaterials ◽  
2016 ◽  
Vol 92 ◽  
pp. 25-35 ◽  
Author(s):  
Si Chen ◽  
Qi Lei ◽  
Shi-Ying Li ◽  
Si-Yong Qin ◽  
Hui-Zhen Jia ◽  
...  
Keyword(s):  
Delivery System ◽  
Tumor Therapy ◽  
Dual Responsive

Injectable magnetic hydrogels for self-regulating magnetic hyperthermia and drug release

2021 ◽  
pp. 2150169
Author(s):  
Xudong Zuo ◽  
Huang Tang ◽  
Xiaoqin Zhu ◽  
Dongmei Zhang ◽  
Wei Gao
Keyword(s):  
Drug Release ◽  
Curie Temperature ◽  
Tumor Therapy ◽  
Sodium Hyaluronate ◽  
Magnetic Hyperthermia ◽  
Temperature Sensitive ◽  
Therapeutic Effects ◽  
Chemotherapy Drugs ◽  
Magnetic Heating

Magnetic hyperthermia can improve therapeutic effects of chemotherapy drugs. Injectable magnetic hydrogels are considered as promising materials for synergistic treatments of magnetic hyperthermia and chemotherapy. However, most works only focused on Fe3O4 nanoparticles-based magnetic hydrogels, which cannot self-regulate hyperthermia temperature due to their high Curie temperature. In this paper, [Formula: see text] nanoparticles with Curie temperature at 45.7[Formula: see text]C were introduced into chitosan/glycerophosphate/sodium hyaluronate hydrogels for preparing injectable magnetic hydrogels. The morphology, magnetic heating properties, rheological properties and drug release behaviors of magnetic hydrogels were investigated systematically. Magnetic heating experiments demonstrated that the magnetic hydrogels can self-regulate temperature at 42.6–43.1[Formula: see text]C though magnetic phase transition, satisfy the temperature requirement of hyperthermia. In vitro adriamycin hydrochloride (DOX) release experiments demonstrated that the magnetic hydrogels can release DOX for more than 120 h, and their release processes were pH- and temperature-sensitive, which can improve the DOX utilization in clinical treatments. These data may provide useful information for further research on magnetic hydrogels-based multi-modal tumor therapy.

A charge-conversional intracellular-activated polymeric prodrug for tumor therapy

2016 ◽  
Vol 7 (12) ◽  
pp. 2253-2263 ◽  
Author(s):  
Yue Wang ◽  
Shixian Lv ◽  
Mingxiao Deng ◽  
Zhaohui Tang ◽  
Xuesi Chen
Keyword(s):  
Drug Release ◽  
Tumor Therapy ◽  
Circulation Time ◽  
Cellular Internalization ◽  
Dual Responsive ◽  
Polymeric Prodrug ◽  
Responsive Polymer ◽  
A Charge

A pH and redox dual responsive polymer–PTX conjugate with a prolonged circulation time, enhanced cellular internalization and timely intracellular drug release, is reported.

scholarly journals Incorporation of Dual-Stimuli Responsive Microgels in Nanofibrous Membranes for Cancer Treatment by Magnetic Hyperthermia

Gels ◽  
2021 ◽  
Vol 7 (1) ◽  
pp. 28
Author(s):  
Adriana Gonçalves ◽  
Filipe V. Almeida ◽  
João Paulo Borges ◽  
Paula I. P. Soares
Keyword(s):  
Young Modulus ◽  
Magnetic Hyperthermia ◽  
Vinyl Pyrrolidone ◽  
Great Promise ◽  
Hydrodynamic Diameter ◽  
Stimuli Responsive ◽  
Dual Responsive ◽  
Material Stiffness ◽  
Isopropyl Acrylamide ◽  
Poly Vinyl Pyrrolidone

The delivery of multiple anti-cancer agents holds great promise for better treatments. The present work focuses on developing multifunctional materials for simultaneous and local combinatory treatment: Chemotherapy and hyperthermia. We first produced hybrid microgels (MG), synthesized by surfactant-free emulsion polymerization, consisting of Poly (N-isopropyl acrylamide) (PNIPAAm), chitosan (40 wt.%), and iron oxide nanoparticles (NPs) (5 wt.%) as the inorganic component. PNIPAAm MGs with a hydrodynamic diameter of about 1 μm (in their swollen state) were successfully synthesized. With the incorporation of chitosan and NPs in PNIPAAm MG, a decrease in MG diameter and swelling capacity was observed, without affecting their thermosensitivity. We then sought to produce biocompatible and mechanically robust membranes containing these dual-responsive MG. To achieve this, MG were incorporated in poly (vinyl pyrrolidone) (PVP) fibers through colloidal electrospinning. The presence of NPs in MG decreases the membrane swelling ratio from 10 to values between 6 and 7, and increases the material stiffness, raising its Young modulus from 20 to 35 MPa. Furthermore, magnetic hyperthermia assay shows that PVP-MG-NP composites perform better than any other formulation, with a temperature variation of about 1 °C. The present work demonstrates the potential of using multifunctional colloidal membranes for magnetic hyperthermia and may in the future be used as an alternative treatment for cancer.

scholarly journals A Rapid Dual-Responsive Releasing Nano-Carrier by Decomposing the Copolymer and Reversing the Core Dissolution

2021 ◽  
Vol 9 ◽  
Author(s):  
Sen Liu ◽  
Can Shen ◽  
Cheng Qian ◽  
Jianquan Wang ◽  
Zhihao Wang ◽  
...  
Keyword(s):  
Drug Release ◽  
Disulfide Bonds ◽  
Water Soluble ◽  
Drug Release Rate ◽  
The Core ◽  
Dual Responsive ◽  
Dual Response ◽  
Effective Drugs

The accumulation of nanotechnology-based drugs has been realized in various ways. However, the concentration of drugs encapsulated by nanomaterials is not equal to the concentration of effective drugs; often, the drugs become effective only when they are released from the nanomaterials as free drugs. This means only when the drugs are rapidly released after the accumulated drug-encapsulating nanomaterials can they truly achieve the purpose of increasing the concentration of drugs in the tumor. Therefore, we herein report a dual-response nano-carrier of glutathione and acid to achieve the rapid release of encapsulated drug and increase the effective drug concentration in the tumor. The nano-carrier was constructed using a dual-responsive amphiphilic copolymer, composed of polyethylene glycol and hydrophobic acetylated dextran and connected by a disulfide bond. In the tumor microenvironment, disulfide bonds could be biodegraded by glutathione that is overexpressed in the tumor, exposing the core of nano-carrier composed of acetylated dextran. Then the acidic environment would induce the deacetylation of acetylated dextran into water-soluble dextran. In this way, the nano-carrier will degrade quickly, realizing the purpose of rapid drug release. The results showed that the drug release rate of dual-responsive nano-carrier was much higher than that of glutathione or acid-responsive nano-carrier alone. Furthermore, both in vitro and in vivo experiments confirmed that dual-responsive nano-carrier possessed more efficient anti-tumor effects. Therefore, we believe that dual-responsive nano-carriers have better clinical application prospects.

A self-assembled pH/enzyme dual-responsive prodrug with PEG deshielding for multidrug-resistant tumor therapy

2020 ◽  
Vol 8 (6) ◽  
pp. 1290-1301 ◽  
Author(s):  
Ronghua Ni ◽  
Jianhua Zhu ◽  
Zhiyuan Xu ◽  
Yun Chen
Keyword(s):  
Multidrug Resistance ◽  
Tumor Therapy ◽  
Multidrug Resistant ◽  
Dual Responsive ◽  
Self Assembled

Multidrug resistance (MDR) is one of the major obstacles for tumor therapy.

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