A charge-conversional intracellular-activated polymeric prodrug for tumor therapy

2016 ◽  
Vol 7 (12) ◽  
pp. 2253-2263 ◽  
Author(s):  
Yue Wang ◽  
Shixian Lv ◽  
Mingxiao Deng ◽  
Zhaohui Tang ◽  
Xuesi Chen
Keyword(s):  
Drug Release ◽  
Tumor Therapy ◽  
Circulation Time ◽  
Cellular Internalization ◽  
Dual Responsive ◽  
Polymeric Prodrug ◽  
Responsive Polymer ◽  
A Charge

A pH and redox dual responsive polymer–PTX conjugate with a prolonged circulation time, enhanced cellular internalization and timely intracellular drug release, is reported.

Synthesis of thermal and oxidation dual responsive polymers for reactive oxygen species (ROS)-triggered drug release

2015 ◽  
Vol 6 (5) ◽  
pp. 738-747 ◽  
Author(s):  
Chunsheng Xiao ◽  
Jianxun Ding ◽  
Lili Ma ◽  
Chenguang Yang ◽  
Xiuli Zhuang ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Drug Release ◽  
Main Chain ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Responsive Polymers ◽  
Dual Responsive ◽  
Responsive Polymer ◽  
Triggered Drug Release

A PEG-based main chain thermo-responsive polymer with oxidation-triggerable thioether groups: synthesis, characterization and its use for ROS-responsive drug release.

Dual-Responsive Polyprodrug Nanoparticles with Cascade-Enhanced Magnetic Resonance Signals for Deep-Penetration Drug Release in Tumor Therapy

2020 ◽  
Vol 12 (44) ◽  
pp. 49489-49501
Author(s):  
Qiubo Hao ◽  
Zhixiong Wang ◽  
Wei Zhao ◽  
Liewei Wen ◽  
Wenhui Wang ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Drug Release ◽  
Tumor Therapy ◽  
Deep Penetration ◽  
Dual Responsive

Intelligent CO2- and photo-dual-responsive polymer vesicles with tunable wall thickness

2019 ◽  
Vol 10 (13) ◽  
pp. 1610-1618 ◽  
Author(s):  
Jia Tian ◽  
Baoxuan Huang ◽  
Chao Xiao ◽  
Philipp Vana
Keyword(s):  
Drug Release ◽  
Wall Thickness ◽  
Dual Responsive ◽  
Polymer Vesicles ◽  
Responsive Polymer

CO2- and photo-dual-responsive polymer vesicles with tunable wall thickness were explored and used as a potential “smart” platform for drug release.

Tailor-made legumain/pH dual-responsive doxorubicin prodrug-embedded nanoparticles for efficient anticancer drug delivery and in situ monitoring of drug release

Nanoscale ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 2673-2685 ◽  
Author(s):  
Yang Li ◽  
Yimin Niu ◽  
Jianhua Zhu ◽  
Cuicui Gao ◽  
Qunwei Xu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Stromal Cells ◽  
Tumor Therapy ◽  
In Situ Monitoring ◽  
Anticancer Drug Delivery ◽  
Dual Responsive ◽  
Lysosomal Cysteine Protease ◽  
Embedded Nanoparticles

Legumain enzyme is a well-conserved lysosomal cysteine protease that is overexpressed in many tumor cells and tumor stromal cells. Herein, we developed a legumain/pH double-sensitive nanosystem for targeted tumor therapy.

Dual pH-responsive micelles with both charge-conversional property and hydrophobic–hydrophilic transition for effective cellular uptake and intracellular drug release

2016 ◽  
Vol 7 (12) ◽  
pp. 2202-2208 ◽  
Author(s):  
Shuai Li ◽  
Zhouxiang Zhao ◽  
Wei Wu ◽  
Chunmei Ding ◽  
Jianshu Li
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Cellular Uptake ◽  
Diblock Copolymers ◽  
Effective Drug ◽  
Ph Responsive ◽  
A Charge

Two types of diblock copolymers are synthesized to construct dual pH-responsive micelles with a charge-conversional property for effective drug delivery.

Sign in / Sign up

Export Citation Format

Share Document