Catalytic enantioselective and regioselective substitution of 2,3-indolyldimethanols with enaminones

2018 ◽  
Vol 5 (18) ◽  
pp. 2657-2667 ◽  
Author(s):  
Yi-Nan Lu ◽  
Chun Ma ◽  
Jin-Ping Lan ◽  
Caiqiang Zhu ◽  
Yu-Jia Mao ◽  
...  
Keyword(s):  
New Class ◽  
Regioselective Substitution ◽  
Catalytic Asymmetric ◽  
Cyclic Enaminones

2,3-Indolyldimethanols as a new class of indolyldimethanols have been designed, and the first catalytic asymmetric substitution of 2,3-indolyldimethanols has been established by using cyclic enaminones as nucleophiles.

Cyclic enaminones. Part I: stereocontrolled synthesis using diastereoselective and catalytic asymmetric methods

2015 ◽  
Vol 51 (92) ◽  
pp. 16437-16449 ◽  
Author(s):  
Amit Kumar Chattopadhyay ◽  
Stephen Hanessian
Keyword(s):  
Stereocontrolled Synthesis ◽  
Catalytic Asymmetric ◽  
Cyclic Enaminones ◽  
Stereoselective Syntheses

Here, we summarize three approaches for stereoselective syntheses of cyclic enaminones and their functionalized derivatives. These include chiral substrates (chirons) as starting materials, syntheses employing non-catalytic (stoichiometric) reagents, and catalytic asymmetric methods.

Catalytic Asymmetric Aza-ene Reaction of 3-Indolylmethanols with Cyclic Enaminones: Enantioselective Approach to C3-Functionalized Indoles

2014 ◽  
Vol 79 (10) ◽  
pp. 4635-4643 ◽  
Author(s):  
Wei Tan ◽  
Bai-Xiang Du ◽  
Xin Li ◽  
Xu Zhu ◽  
Feng Shi ◽  
...  
Keyword(s):  
Ene Reaction ◽  
Catalytic Asymmetric ◽  
Cyclic Enaminones

N-Salicyl-β-aminoalcohols as a New Class of Ligand for Catalytic Asymmetric Strecker Reactions.

ChemInform ◽  
2003 ◽  
Vol 34 (33) ◽  
Author(s):  
Woraluk Mansawat ◽  
Worawan Bhanthumnavin ◽  
Tirayut Vilaivan
Keyword(s):  
New Class ◽  
Catalytic Asymmetric

A catalytic asymmetric interrupted Nazarov-type cyclization of 2-indolylmethanols with cyclic enaminones

2018 ◽  
Vol 16 (30) ◽  
pp. 5457-5464 ◽  
Author(s):  
Jia-Le Wu ◽  
Cong-Shuai Wang ◽  
Jin-Rong Wang ◽  
Guang-Jian Mei ◽  
Feng Shi
Keyword(s):  
Phosphoric Acid ◽  
Chiral Phosphoric Acid ◽  
Acid Catalyzed ◽  
Catalytic Asymmetric ◽  
Cyclic Enaminones

A chiral phosphoric acid-catalyzed asymmetric interrupted Nazarov-type cyclization of C3-alkenyl-substituted 2-indolylmethanols has been established by using cyclic enaminones as nucleophiles.

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