scholarly journals Tuning the hydrophobic cores of self-immolative polyglyoxylate assemblies

2018 ◽  
Vol 9 (19) ◽  
pp. 2601-2610 ◽  
Author(s):  
Bo Fan ◽  
Rebecca E. Yardley ◽  
John F. Trant ◽  
Aneta Borecki ◽  
Elizabeth R. Gillies
Keyword(s):  
Block Copolymers ◽  
Drug Carriers ◽  
Amphiphilic Block Copolymers ◽  
Release Rates ◽  
Self Assembled ◽  
Hydrophobic Cores

Amphiphilic block copolymers containing different self-immolative polyglyoxylates were synthesized and self-assembled to provide drug carriers with variable celecoxib loading capacities and release rates, as well as different in vitro toxicities.

scholarly journals Self-Assembled Nanostructures of Red Fluorescent Amphiphilic Block Copolymers as Both Imaging Probes and Drug Carriers

Polymers ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 1120 ◽  
Author(s):  
Shuo Huang ◽  
Xin Wei ◽  
Mingfeng Wang
Keyword(s):  
Block Copolymers ◽  
Drug Loading ◽  
Drug Carriers ◽  
Amphiphilic Block Copolymers ◽  
Intracellular Release ◽  
Transmission Electron ◽  
Amorphous Block ◽  
Covalently Bonded ◽  
Imaging Probes ◽  
Self Assembled

We report a red-fluorescent drug delivery system formed by biodegradable and biocompatible amphiphilic A-B-A block copolymers. Each polymer consists of a red fluorescent dye covalently bonded in the middle of hydrophobic block (B) of polylactone, tethered at both ends with poly[(oligo ethylene glycol) methyl ether methacrylate] (POEGMA) as the hydrophilic block. Two types of polylactones, i.e., semicrystalline poly(ε-caprolactone) (PCL) and amorphous poly(δ-decalactone) (PDL), respectively, were incorporated as the hydrophobic segment in the block copolymers. Using transmission electron microscopy, we characterized the self-assembled nanostructures formed by these amphiphilic block copolymers in mixtures of water/tetrahydrofuran or water/dimethylformamide. All of these polymers remained highly fluorescent in water, although some extent of aggregation-induced fluorescence quenching was still observed. Among the three types of polymers presented here, the polymer (RPO-3) containing an amorphous block of PDL showed the highest drug-loading capacity and the largest extent of drug release in acidic media. RPO-3 micelles loaded with doxorubicin as a model of anticancer drug showed sustainable intracellular release and cytotoxicity against HeLa cells.

Slowing the translocation of single-stranded DNA by using nano-cylindrical passage self-assembled by amphiphilic block copolymers

Nanoscale ◽  
2016 ◽  
Vol 8 (43) ◽  
pp. 18270-18276 ◽  
Author(s):  
Hiroshi Yoshida ◽  
Yusuke Goto ◽  
Rena Akahori ◽  
Yasuhiko Tada ◽  
Shohei Terada ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Amphiphilic Block Copolymers ◽  
Single Stranded Dna ◽  
Self Assembled

scholarly journals Structural hierarchy in blends of amphiphilic block copolymers self-assembled at the air-water interface

2019 ◽  
Vol 556 ◽  
pp. 392-400 ◽  
Author(s):  
Janet Hood ◽  
Kyle Van Gordon ◽  
Patricia Thomson ◽  
Brian R. Coleman ◽  
Fraser Burns ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Amphiphilic Block Copolymers ◽  
Water Interface ◽  
Structural Hierarchy ◽  
Air Water Interface ◽  
Self Assembled

Phase separation and self-assembly of cyclic amphiphilic block copolymers with a main-chain liquid crystalline segment

2015 ◽  
Vol 6 (22) ◽  
pp. 4167-4176 ◽  
Author(s):  
Satoshi Honda ◽  
Maito Koga ◽  
Masatoshi Tokita ◽  
Takuya Yamamoto ◽  
Yasuyuki Tezuka
Keyword(s):  
Phase Separation ◽  
Solid State ◽  
Block Copolymers ◽  
Electric Field ◽  
Self Assembly ◽  
Liquid Crystalline ◽  
Main Chain ◽  
Amphiphilic Block Copolymers ◽  
Cylindrical Micelles ◽  
Self Assembled

The effects of the macrocyclization of amphiphiles with a liquid crystalline segment were investigated in the solid state, and electric field-responsive cylindrical micelles and vesicles were self-assembled.

Functionalization of Magnetic Nanoparticles with Amphiphilic Block Copolymers: Self-Assembled Thermoresponsive Submicrometer Particles

Langmuir ◽  
2012 ◽  
Vol 28 (9) ◽  
pp. 4142-4151 ◽  
Author(s):  
Angela M. Budgin ◽  
Yuri A. Kabachii ◽  
Zinaida B. Shifrina ◽  
Pyotr M. Valetsky ◽  
Sergey S. Kochev ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Block Copolymers ◽  
Amphiphilic Block Copolymers ◽  
Self Assembled

Hypoxia-responsive micelles self-assembled from amphiphilic block copolymers for the controlled release of anticancer drugs

2019 ◽  
Vol 7 (2) ◽  
pp. 286-295 ◽  
Author(s):  
Yinlu Deng ◽  
Hua Yuan ◽  
Weizhong Yuan
Keyword(s):  
Controlled Release ◽  
Block Copolymers ◽  
Anticancer Drugs ◽  
Amphiphilic Block Copolymers ◽  
Hypoxic Conditions ◽  
Copolymer Micelles ◽  
Self Assembled

Hypoxia-responsive PEG-b-P(MAA-co-NIMA) copolymer micelles expanded under hypoxic conditions and achieved the controlled release of anticancer DOX molecules.

Synthesis and self-assembly of polyethersulfone-based amphiphilic block copolymers as microparticles for suspension immunosensors

2020 ◽  
Vol 11 (8) ◽  
pp. 1496-1503 ◽  
Author(s):  
Weibin Hu ◽  
Xiaohong He ◽  
Yun Bai ◽  
Li Zheng ◽  
Yiguo Hu ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Block Copolymers ◽  
Self Assembly ◽  
Amphiphilic Block Copolymers ◽  
Amphiphilic Block Copolymer ◽  
Diagnostic Application

Polyethersulfone (PES) based amphiphilic block copolymer has been synthesized and transformed into immunological microparticles via confined emulsion self-assembly and surface biomodification, opens the in-vitro diagnostic application of PES.

scholarly journals Micelle-Forming Block Copolymers Tailored for Inhibition of P-gp-Mediated Multidrug Resistance: Structure to Activity Relationship

Pharmaceutics ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 579 ◽  
Author(s):  
Braunová ◽  
Kaňa ◽  
Kudláčová ◽  
Kostka ◽  
Bouček ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Block Copolymers ◽  
Drug Carriers ◽  
Biological Properties ◽  
Polypropylene Glycol ◽  
Polymer Micelles ◽  
Glycoprotein P ◽  
Block Polymer

Multidrug resistance (MDR) is often caused by the overexpression of efflux pumps, such as ABC transporters, in particular, P-glycoprotein (P-gp). Here, we investigate the di- and tri- block amphiphilic polymer systems based on polypropylene glycol (PPO) and copolymers of (N-(2-hydroxypropyl)methacrylamide) (PHPMA) as potential macromolecular inhibitors of P-gp, and concurrently, carriers of drugs, passively targeting solid tumors by the enhanced permeability and retention (EPR) effect. Interestingly, there were significant differences between the effects of di- and tri- block polymer-based micelles, with the former being significantly more thermodynamically stable and showing much higher P-gp inhibition ability. The presence of Boc-protected hydrazide groups or the Boc-deprotection method did not affect the physico-chemical or biological properties of the block copolymers. Moreover, diblock polymer micelles could be loaded with free PPO containing 5–40 wt % of free PPO, which showed increased P-gp inhibition in comparison to the unloaded micelles. Loaded polymer micelles containing more than 20 wt % free PPO showed a significant increase in toxicity; thus, loaded diblock polymer micelles containing 5–15 wt % free PPO are potential candidates for in vitro and in vivo application as potent MDR inhibitors and drug carriers.

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