pH-Responsive Micelles Based on Amphiphilic Block Copolymers Bearing Ortho Ester Pendants as Potential Drug Carriers

2011 ◽  
Vol 212 (11) ◽  
pp. 1185-1192 ◽  
Author(s):  
Rupei Tang ◽  
Weihang Ji ◽  
Chun Wang
Keyword(s):  
Block Copolymers ◽  
Drug Carriers ◽  
Amphiphilic Block Copolymers ◽  
Potential Drug ◽  
Ph Responsive ◽  
Ortho Ester

scholarly journals Development of acid-sensitive copolymer micelles for drug delivery

2004 ◽  
Vol 76 (7-8) ◽  
pp. 1295-1307 ◽  
Author(s):  
E. R. Gillies ◽  
J. M. J. Fréchet
Keyword(s):  
Drug Release ◽  
Drug Carrier ◽  
Micelle Formation ◽  
Drug Carriers ◽  
Amphiphilic Block Copolymers ◽  
Acidic Ph ◽  
Potential Drug ◽  
Specific Location ◽  
Copolymer Micelles ◽  
Direct Attachment

In recent years, supramolecular micellar assemblies formed from amphiphilic block copolymers have been receiving attention as potential drug carriers. The size of the carriers is ideal for avoiding rapid renal exclusion and reticuloendothelial uptake, and enables them to be targeted to certain tissues such as tumors. One important issue determining the effectiveness of a micellar drug carrier is the ability to control the time over which drug release takes place, or to possibly trigger drug release at a specific location or time. The mildly acidic pH encountered in tumor and inflammatory tissues as well as in the endosomal and lysosomal compartments of cells has inspired the development of micellar carriers capable of releasing their drug load in response to small changes in pH. One approach to the development of these systems has been to incorporate “titratable” groups such as amines and carboxylic acids into the copolymer backbone, thus altering the solubility of the polymer upon protonation and disrupting micelle formation. Another approach has been to incorporate acid-degradable linkages into the copolymer, either for direct attachment of the drug, or to cause a structural change of such magnitude that micellar integrity is lost and the drug is released.

pH-Responsive Nanostructures Assembled from Amphiphilic Block Copolymers

2006 ◽  
Vol 39 (18) ◽  
pp. 6063-6070 ◽  
Author(s):  
Chen Xu ◽  
Bradford B. Wayland ◽  
Michael Fryd ◽  
Karen I. Winey ◽  
Russell J. Composto
Keyword(s):  
Block Copolymers ◽  
Amphiphilic Block Copolymers ◽  
Ph Responsive

scholarly journals Self-Assembled Nanostructures of Red Fluorescent Amphiphilic Block Copolymers as Both Imaging Probes and Drug Carriers

Polymers ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 1120 ◽  
Author(s):  
Shuo Huang ◽  
Xin Wei ◽  
Mingfeng Wang
Keyword(s):  
Block Copolymers ◽  
Drug Loading ◽  
Drug Carriers ◽  
Amphiphilic Block Copolymers ◽  
Intracellular Release ◽  
Transmission Electron ◽  
Amorphous Block ◽  
Covalently Bonded ◽  
Imaging Probes ◽  
Self Assembled

We report a red-fluorescent drug delivery system formed by biodegradable and biocompatible amphiphilic A-B-A block copolymers. Each polymer consists of a red fluorescent dye covalently bonded in the middle of hydrophobic block (B) of polylactone, tethered at both ends with poly[(oligo ethylene glycol) methyl ether methacrylate] (POEGMA) as the hydrophilic block. Two types of polylactones, i.e., semicrystalline poly(ε-caprolactone) (PCL) and amorphous poly(δ-decalactone) (PDL), respectively, were incorporated as the hydrophobic segment in the block copolymers. Using transmission electron microscopy, we characterized the self-assembled nanostructures formed by these amphiphilic block copolymers in mixtures of water/tetrahydrofuran or water/dimethylformamide. All of these polymers remained highly fluorescent in water, although some extent of aggregation-induced fluorescence quenching was still observed. Among the three types of polymers presented here, the polymer (RPO-3) containing an amorphous block of PDL showed the highest drug-loading capacity and the largest extent of drug release in acidic media. RPO-3 micelles loaded with doxorubicin as a model of anticancer drug showed sustainable intracellular release and cytotoxicity against HeLa cells.

scholarly journals Design of a pH-Responsive Conductive Nanocomposite Based on MWCNTs Stabilized in Water by Amphiphilic Block Copolymers

Nanomaterials ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. 1410 ◽  
Author(s):  
den Hoed ◽  
Pucci ◽  
Picchioni ◽  
Raffa
Keyword(s):  
Carbon Nanotubes ◽  
Block Copolymers ◽  
Acrylic Acid ◽  
Zeta Potential ◽  
Amphiphilic Block Copolymers ◽  
Ph Responsive ◽  
Potential Applications ◽  
Multi Walled Carbon Nanotubes ◽  
Responsive Behavior ◽  
Walled Carbon Nanotubes

Homogeneous water dispersions of multi-walled carbon nanotubes (MWCNTs) were prepared by ultrasonication in the presence of an amphiphilic polystyrene-block-poly(acrylic acid) (PS-b-PAA) copolymer. The ability of PS-b-PAA to disperse and stabilize MWCTNs was investigated by UV-vis, SEM and zeta potential. The results show that the addition of a styrene block to PAA enhances the dispersion efficiency of the graphitic filler compared to pure PAA, possibly due to the nanotube affinity with the polystyrene moiety. Notably, the dispersions show an evident pH-responsive behavior, being MWCNTs reaggregation promoted in basic environment. It is worth noting that the responsive character is maintained in solid composites obtained by drop casting, thus indicating potential applications in sensing.

scholarly journals Tuning the hydrophobic cores of self-immolative polyglyoxylate assemblies

2018 ◽  
Vol 9 (19) ◽  
pp. 2601-2610 ◽  
Author(s):  
Bo Fan ◽  
Rebecca E. Yardley ◽  
John F. Trant ◽  
Aneta Borecki ◽  
Elizabeth R. Gillies
Keyword(s):  
Block Copolymers ◽  
Drug Carriers ◽  
Amphiphilic Block Copolymers ◽  
Release Rates ◽  
Self Assembled ◽  
Hydrophobic Cores

Amphiphilic block copolymers containing different self-immolative polyglyoxylates were synthesized and self-assembled to provide drug carriers with variable celecoxib loading capacities and release rates, as well as different in vitro toxicities.

Acid-degradable poly(ortho ester urethanes) copolymers for potential drug carriers: Preparation, characterization, in vitro and in vivo evaluation

Polymer ◽  
2017 ◽  
Vol 114 ◽  
pp. 1-14 ◽  
Author(s):  
Shengxiang Fu ◽  
Guanqing Yang ◽  
Jun Wang ◽  
Xin Wang ◽  
Xu Cheng ◽  
...  
Keyword(s):  
Drug Carriers ◽  
Potential Drug ◽  
Ortho Ester ◽  
In Vivo Evaluation
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