scholarly journals Stabilisation of lipid membrane-incorporated porphyrin derivative aqueous solutions and their photodynamic activities

2019 ◽  
Vol 18 (2) ◽  
pp. 459-466 ◽  
Author(s):  
Toshimi Nakaya ◽  
Banri Horiguchi ◽  
Shodai Hino ◽  
Kouta Sugikawa ◽  
Hisakage Funabashi ◽  
...  
Keyword(s):  
Aqueous Solutions ◽  
Lipid Membrane ◽  
Hydrophilic Surface ◽  
Porphyrin Derivative ◽  
Photodynamic Activity

A porphyrin derivative which exists on the hydrophilic surface of the liposomes showed high photodynamic activity.

The photodynamic activity of a novel porphyrin derivative bearing a fluconazole structure in different media and against Candida albicans

2010 ◽  
Vol 87 (3) ◽  
pp. 234-240 ◽  
Author(s):  
S. Jimena Mora ◽  
M. Paula Cormick ◽  
M. Elisa Milanesio ◽  
Edgardo N. Durantini
Keyword(s):  
Candida Albicans ◽  
Porphyrin Derivative ◽  
Photodynamic Activity

scholarly journals Lipid Membrane Adsorption Determines Photodynamic Efficiency of β-Imidazolyl-Substituted Porphyrins

Biomolecules ◽  
2019 ◽  
Vol 9 (12) ◽  
pp. 853 ◽  
Author(s):  
Irene Jiménez-Munguía ◽  
Arseniy K. Fedorov ◽  
Inna A. Abdulaeva ◽  
Kirill P. Birin ◽  
Yury A. Ermakov ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Singlet Oxygen ◽  
Surface Density ◽  
Lipid Membrane ◽  
Bilayer Lipid Membrane ◽  
Target Cells ◽  
Oxygen Species ◽  
Styryl Dye ◽  
Anti Cancer ◽  
Photodynamic Activity

Photosensitizers (PSs) represent a group of molecules capable of generating reactive oxygen species (ROS), such as singlet oxygen (SO); thus, they are considered to be promising agents for anti-cancer therapy. The enhancement of the photodynamic efficiency of these compounds requires increasing the PS activity in the cancer cell milieu and exactly at the target cells. In the present work, we report the synthesis, lipid membrane binding and photodynamic activity of three novel cationic PSs based on β-imidazolyl-substituted porphyrin and its Zn(II) and In(III) complexes (1H2, 1Zn and 1In). Comparison of the behavior of the investigated porphyrins at the bilayer lipid membrane (BLM) demonstrated the highest adsorption for the 1In complex and the lowest one for 1Zn. The photodynamic efficiency of these porphyrins was evaluated by determining the oxidation rate of the styryl dye, di-4-ANEPPS, incorporated into the lipid membrane. These rates were proportional to the surface density (SD) of the porphyrin molecules at the BLM and were roughly the same for all three porphyrins. This indicates that the adsorption of these porphyrins at the BLM determines their photodynamic efficiency rather than the extinction or quantum yield of singlet oxygen.

Surfactant-induced chirality on reluctant aggregates of a chiral amphiphilic cationic (l)-proline–Zn(ii)porphyrin conjugate in water

RSC Advances ◽  
2014 ◽  
Vol 4 (98) ◽  
pp. 55362-55366 ◽  
Author(s):  
Edoardo Simoncini ◽  
Fabrizio Caroleo ◽  
Francesca Ceccacci ◽  
Giovanna Mancini ◽  
Manuela Stefanelli ◽  
...  
Keyword(s):  
Molecular Recognition ◽  
Aqueous Solutions ◽  
Porphyrin Derivative ◽  
Chiral Surfactants

The aggregation of an amphiphilic chiral Zn(ii)porphyrin derivative occurs in aqueous solutions of chiral surfactants with highly specific molecular recognition.

scholarly journals Improvement of Photodynamic Activity of Lipid–Membrane‐Incorporated Fullerene Derivative by Combination with a Photo‐Antenna Molecule

2018 ◽  
Vol 24 (29) ◽  
pp. 7335-7339 ◽  
Author(s):  
Daiki Antoku ◽  
Shuhei Satake ◽  
Tomoya Mae ◽  
Kouta Sugikawa ◽  
Hisakage Funabashi ◽  
...  
Keyword(s):  
Lipid Membrane ◽  
Fullerene Derivative ◽  
Photodynamic Activity

Synthetic meroterpenoids based on terpene alcohols: synthesis, self-assembly, and membranotropic properties

2020 ◽  
Vol 63 (7) ◽  
pp. 11-18
Author(s):  
Alan A. Akhmedov ◽  
◽  
Dmitriy N. Shurpik ◽  
Zainab R. Latypova ◽  
Rustem R. Gamirov ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Aqueous Solutions ◽  
Self Assembly ◽  
Lipid Membrane ◽  
Bilayer Membrane ◽  
Water Soluble ◽  
Polar Component ◽  
Terpene Alcohols ◽  
Archaeal Lipids ◽  
Pharmacologically Active

Currently, targeted drug delivery is of great interest in the field of medicine. The study of compounds capable of permeating cell membranes is a major problem in this area. The synthesis of pharmacologically active compounds includes the formation of structures with various combinations of pharmacophore fragments and properties. Amphiphilic compounds tend to exhibit membranotropic activity. From this point of view, the modification of natural products, especially terpenoids, is of particular interest. Terpenoid structures are used as membrane anchors in the development of modulators for membrane-integrated proteins or structures for creating nanocontainers. In this paper we synthesized a number of water-soluble amphiphilic meroterpenoids containing a charged pyridinium fragment on the basis of acyclic terpene alcohols. Residue of terpene alcohols – geraniol (monoterpenol), farnesol (sesquiterpenol), and phytol (diterpenol) – were used as the hydrophobic part of the amphiphilic structure. Linear acyclic alcohols are commercially available reagents and have a structure similar to that of polyprenols in archaeal lipids, which made it possible to obtain synthetic lipid-like meroterpenoids capable of self-assembly in aqueous solutions. The charged pyridinium fragment, which is included in numerous natural compounds, was of interest as a polar component. This meroterpenoids are synthetic analogs of archaeal lipids. It was shown that the studied meroterpenoids form nanosized aggregates in aqueous solutions by the method of dynamic light scattering and the Doppler microelectrophoresis method. Turbidimetric titration on model dipalmitoylphosphatidylcholine vesicles revealed that the synthesized compounds are embedded into the bilayer membrane without destroying it. Self-assembled aggregates of synthesized compounds in water can find application for drug delivery – in the creation of nanocontainers containing membrane anchors capable of interacting with the outer surface of the cell (lipid membrane).

(Invited) Wetting Behavior of Aqueous Solutions on High Aspect Ratio Nanopillars with Hydrophilic Surface Finish

2013 ◽  
Vol 58 (6) ◽  
pp. 171-182 ◽  
Author(s):  
G. Vereecke ◽  
X. Xu ◽  
W.-K. Tsai ◽  
H. Yang ◽  
S. Armini ◽  
...  
Keyword(s):  
Aspect Ratio ◽  
Aqueous Solutions ◽  
Surface Finish ◽  
High Aspect Ratio ◽  
Hydrophilic Surface ◽  
Wetting Behavior

Partial Wetting of Aqueous Solutions on High Aspect Ratio Nanopillars with Hydrophilic Surface Finish

2014 ◽  
Vol 3 (1) ◽  
pp. N3095-N3100 ◽  
Author(s):  
G. Vereecke ◽  
XiuMei Xu ◽  
W. K. Tsai ◽  
Hui Yang ◽  
S. Armini ◽  
...  
Keyword(s):  
Aspect Ratio ◽  
Aqueous Solutions ◽  
Surface Finish ◽  
High Aspect Ratio ◽  
Hydrophilic Surface ◽  
Partial Wetting

scholarly journals Cover Feature: Improvement of Photodynamic Activity of Lipid–Membrane‐Incorporated Fullerene Derivative by Combination with a Photo‐Antenna Molecule (Chem. Eur. J. 29/2018)

2018 ◽  
Vol 24 (29) ◽  
pp. 7274-7274
Author(s):  
Daiki Antoku ◽  
Shuhei Satake ◽  
Tomoya Mae ◽  
Kouta Sugikawa ◽  
Hisakage Funabashi ◽  
...  
Keyword(s):  
Lipid Membrane ◽  
Fullerene Derivative ◽  
Photodynamic Activity
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