scholarly journals Cover Feature: Improvement of Photodynamic Activity of Lipid–Membrane‐Incorporated Fullerene Derivative by Combination with a Photo‐Antenna Molecule (Chem. Eur. J. 29/2018)

2018 ◽  
Vol 24 (29) ◽  
pp. 7274-7274
Author(s):  
Daiki Antoku ◽  
Shuhei Satake ◽  
Tomoya Mae ◽  
Kouta Sugikawa ◽  
Hisakage Funabashi ◽  
...  
Keyword(s):  
Lipid Membrane ◽  
Fullerene Derivative ◽  
Photodynamic Activity

scholarly journals Improvement of Photodynamic Activity of Lipid–Membrane‐Incorporated Fullerene Derivative by Combination with a Photo‐Antenna Molecule

2018 ◽  
Vol 24 (29) ◽  
pp. 7335-7339 ◽  
Author(s):  
Daiki Antoku ◽  
Shuhei Satake ◽  
Tomoya Mae ◽  
Kouta Sugikawa ◽  
Hisakage Funabashi ◽  
...  
Keyword(s):  
Lipid Membrane ◽  
Fullerene Derivative ◽  
Photodynamic Activity

scholarly journals Stabilisation of lipid membrane-incorporated porphyrin derivative aqueous solutions and their photodynamic activities

2019 ◽  
Vol 18 (2) ◽  
pp. 459-466 ◽  
Author(s):  
Toshimi Nakaya ◽  
Banri Horiguchi ◽  
Shodai Hino ◽  
Kouta Sugikawa ◽  
Hisakage Funabashi ◽  
...  
Keyword(s):  
Aqueous Solutions ◽  
Lipid Membrane ◽  
Hydrophilic Surface ◽  
Porphyrin Derivative ◽  
Photodynamic Activity

A porphyrin derivative which exists on the hydrophilic surface of the liposomes showed high photodynamic activity.

Photodynamic activity of a hybrid nanostructure based on a polycationic fullerene derivative and phthalocyanine dye photosens

2013 ◽  
Vol 452 (2) ◽  
pp. 229-232 ◽  
Author(s):  
A. I. Kotel’nikov ◽  
A. Yu. Rybkin ◽  
N. S. Goryachev ◽  
A. Yu. Belik ◽  
A. B. Kornev ◽  
...  
Keyword(s):  
Fullerene Derivative ◽  
Hybrid Nanostructure ◽  
Photodynamic Activity

scholarly journals Lipid Membrane Adsorption Determines Photodynamic Efficiency of β-Imidazolyl-Substituted Porphyrins

Biomolecules ◽  
2019 ◽  
Vol 9 (12) ◽  
pp. 853 ◽  
Author(s):  
Irene Jiménez-Munguía ◽  
Arseniy K. Fedorov ◽  
Inna A. Abdulaeva ◽  
Kirill P. Birin ◽  
Yury A. Ermakov ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Singlet Oxygen ◽  
Surface Density ◽  
Lipid Membrane ◽  
Bilayer Lipid Membrane ◽  
Target Cells ◽  
Oxygen Species ◽  
Styryl Dye ◽  
Anti Cancer ◽  
Photodynamic Activity

Photosensitizers (PSs) represent a group of molecules capable of generating reactive oxygen species (ROS), such as singlet oxygen (SO); thus, they are considered to be promising agents for anti-cancer therapy. The enhancement of the photodynamic efficiency of these compounds requires increasing the PS activity in the cancer cell milieu and exactly at the target cells. In the present work, we report the synthesis, lipid membrane binding and photodynamic activity of three novel cationic PSs based on β-imidazolyl-substituted porphyrin and its Zn(II) and In(III) complexes (1H2, 1Zn and 1In). Comparison of the behavior of the investigated porphyrins at the bilayer lipid membrane (BLM) demonstrated the highest adsorption for the 1In complex and the lowest one for 1Zn. The photodynamic efficiency of these porphyrins was evaluated by determining the oxidation rate of the styryl dye, di-4-ANEPPS, incorporated into the lipid membrane. These rates were proportional to the surface density (SD) of the porphyrin molecules at the BLM and were roughly the same for all three porphyrins. This indicates that the adsorption of these porphyrins at the BLM determines their photodynamic efficiency rather than the extinction or quantum yield of singlet oxygen.

Photodynamic activity of hybrid nanostructure on the basis of polycationic fullerene derivative and xanthene dye eosine Y

2012 ◽  
Vol 7 (7-8) ◽  
pp. 409-414 ◽  
Author(s):  
A. V. Barinov ◽  
N. S. Goryachev ◽  
D. A. Poletaeva ◽  
A. Yu. Rybkin ◽  
A. B. Kornev ◽  
...  
Keyword(s):  
Fullerene Derivative ◽  
Hybrid Nanostructure ◽  
Photodynamic Activity

Ubiquinone-BODIPY nanoparticles for tumor redox-responsive fluorescence imaging and photodynamic activity

2021 ◽  
Author(s):  
Byunghee Hwang ◽  
Tae-Il Kim ◽  
Hyunjin Kim ◽  
Sungjin Jeon ◽  
Yongdoo Choi ◽  
...  
Keyword(s):  
Fluorescence Imaging ◽  
Selective Activation ◽  
Turn On ◽  
Intracellular Environment ◽  
Redox Responsive ◽  
Photodynamic Activity

A ubiquinone-BODIPY photosensitizer self-assembles into nanoparticles (PS-Q-NPs) and undergoes selective activation within the highly reductive intracellular environment of tumors, resulting in “turn-on” fluorescence and photosensitizing activities.

Chapter 2b: The molecular antigenic structure of the TBEV

2020 ◽  
Keyword(s):  
Conformational Changes ◽  
Neutralizing Antibodies ◽  
Lipid Membrane ◽  
Cell Entry ◽  
Antigenic Structure ◽  
E Proteins ◽  
Amino Acid Sequence Level ◽  
Endosomal Membrane ◽  
E Protein ◽  
Golgi Network

TBEV-particles are assembled in an immature, noninfectious form in the endoplasmic reticulum by the envelopment of the viral core (containing the viral RNA) by a lipid membrane associated with two viral proteins, prM and E. Immature particles are transported through the cellular exocytic pathway and conformational changes induced by acidic pH in the trans-Golgi network allow the proteolytic cleavage of prM by furin, a cellular protease, resulting in the release of mature and infectious TBE-virions. The E protein controls cell entry by mediating attachment to as yet ill-defined receptors as well as by low-pH-triggered fusion of the viral and endosomal membrane after uptake by receptor-mediated endocytosis. Because of its key functions in cell entry, the E protein is the primary target of virus neutralizing antibodies, which inhibit these functions by different mechanisms. Although all flavivirus E proteins have a similar overall structure, divergence at the amino acid sequence level is up to 60 percent (e.g. between TBE and dengue viruses), and therefore cross-neutralization as well as (some degree of) cross-protection are limited to relatively closely related flaviviruses, such as those constituting the tick-borne encephalitis serocomplex.

Electrophysiological Characterization of Transport Across Outer Membrane Channels from Gram-Negative Bacteria in Their Native Environment

2019 ◽  
Author(s):  
Jiajun Wang ◽  
Rémi Terrasse ◽  
Jayesh Arun Bafna ◽  
Lorraine Benier ◽  
Mathias Winterhalter
Keyword(s):  
Outer Membrane ◽  
Lipid Membrane ◽  
Membrane Vesicles ◽  
Outer Membrane Vesicles ◽  
Multi Drug Resistance ◽  
Gram Negative Bacteria ◽  
Membrane Channels ◽  
Gram Negative ◽  
Electrophysiological Characterization

Multi-drug resistance in Gram-negative bacteria is often associated with low permeability of the outer membrane. To investigate the role of membrane channels in the uptake of antibiotics, we extract, purify and reconstitute them into artificial planar membranes. To avoid this time-consuming procedure, here we show a robust approach using fusion of native outer membrane vesicles (OMV) into planar lipid bilayer which moreover allows also to some extend the characterization of membrane protein channels in their native environment. Two major membrane channels from <i>Escherichia coli</i>, OmpF and OmpC, were overexpressed from the host and the corresponding OMVs were collected. Each OMV fusion revealed surprisingly single or only few channel activities. The asymmetry of the OMV´s translates after fusion into the lipid membrane with the LPS dominantly present at the side of OMV addition. Compared to conventional reconstitution methods, the channels fused from OMVs containing LPS have similar conductance but a much broader distribution. The addition of Enrofloxacin on the LPS side yields somewhat higher association (<i>k<sub>on</sub></i>) and lower dissociation (<i>k<sub>off</sub></i>) rates compared to LPS-free reconstitution. We conclude that using outer membrane vesicles is a fast and easy approach for functional and structural studies of membrane channels in the native membrane.

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