Enantiomeric NMR discrimination of carboxylic acids using actinomycin D as a chiral solvating agent

2019 ◽  
Vol 17 (6) ◽  
pp. 1466-1470 ◽  
Author(s):  
Liwen Bai ◽  
Pian Chen ◽  
Jiangxia Xiang ◽  
Jiarui Sun ◽  
Xinxiang Lei
Keyword(s):  
Nmr Spectroscopy ◽  
Carboxylic Acids ◽  
Actinomycin D ◽  
H Nmr ◽  
Chiral Solvating Agent

We extended actinomycin D as a practical CSA for rapid enantiomeric determination of chiral carboxylic acids by1H NMR spectroscopy.

Determination of the content of fatty acid methyl esters (FAME) in biodiesel samples obtained by esterification using 1 H-NMR spectroscopy

2008 ◽  
Vol 46 (11) ◽  
pp. 1051-1054 ◽  
Author(s):  
Vinicius M. Mello ◽  
Flavia C. C. Oliveira ◽  
William G. Fraga ◽  
Claudia J. do Nascimento ◽  
Paulo A. Z. Suarez
Keyword(s):  
Fatty Acid ◽  
Nmr Spectroscopy ◽  
Fatty Acid Methyl Esters ◽  
Methyl Esters ◽  
H Nmr ◽  
Acid Methyl

Macrocyclic Compound as NMR Chiral Solvating Agent for Determination of Enantiomeric Excess of Carboxylic Acids

2013 ◽  
Vol 86 (8) ◽  
pp. 987-989 ◽  
Author(s):  
Xiao-feng Yang ◽  
Rui Ning ◽  
Li-jun Xie ◽  
Yu Cui ◽  
Yong-ling Zhang ◽  
...  
Keyword(s):  
Carboxylic Acids ◽  
Enantiomeric Excess ◽  
Macrocyclic Compound ◽  
Chiral Solvating Agent

Determination of Alcohols, Phenols, and Carboxylic Acids Using Phosphorus-31 NMR Spectroscopy

1986 ◽  
Vol 40 (3) ◽  
pp. 348-351 ◽  
Author(s):  
David E. Schiff ◽  
John G. Verkade ◽  
Robert M. Metzler ◽  
Thomas G. Squires ◽  
Clifford G. Venier
Keyword(s):  
Free Radical ◽  
Nmr Spectroscopy ◽  
Carboxylic Acids ◽  
Chemical Shifts ◽  
Relaxation Times ◽  
Oh Groups

Derivatization of compounds containing -OH groups can be accomplished quantitatively with 1,3,2-dioxaphospholanyl chloride. The chemical shifts of phosphorus in the derivatives clearly differentiate alcohols from phenols and carboxylic acids. Quantitation is obtained by use of 31P FT-NMR spectroscopy in the presence of 2,2,6,6-tetrameth-ylpiperidinyloxy free radical to shorten relaxation times. Compounds with phosphorus chemical shifts differing by as little as 0.1 ppm can be separately determined.

Chemical Shift Nonequivalence of Enantiomers of Amino Acid Derivatives in 1H NMR and 19F NMR Spectroscopy Induced by L-Chirasil- Val.

1992 ◽  
Vol 47 (7) ◽  
pp. 1034-1036 ◽  
Author(s):  
Bernhard Koppenhoefer ◽  
Michael Hummel
Keyword(s):  
Amino Acid ◽  
Nmr Spectroscopy ◽  
Chemical Shift ◽  
Methyl Esters ◽  
Enantiomeric Purity ◽  
Peak Splitting ◽  
H Nmr ◽  
Acid Methyl ◽  
Amino Acid Methyl Esters

Enantiomers of N-trifluoroacetyl-amino acid methyl esters in CC14 solution, after addition of the chiral polysiloxane (L)-Chirasil-Val, display a chemical shift nonequivalence ΔΔδ in both 1H NMR and 19F NMR spectroscopy. The effects found for the leucine and valine derivatives can be correlated with the thermodynamic parameters of interaction in the undiluted system, as determined by gas chromatography. In CDC13 solution, no peak splitting was observed. The method is potentially useful for the determination of the enantiomeric purity of substrates of low volatility.

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