Site-specific hydroxyalkylation of chromones via alcohol mediated Minisci-type radical conjugate addition

2018 ◽  
Vol 16 (11) ◽  
pp. 1823-1827 ◽  
Author(s):  
Rongzhen Chen ◽  
Jin-Tao Yu ◽  
Jiang Cheng
Keyword(s):  
Conjugate Addition ◽  
Site Specific ◽  
Metal Free ◽  
Type Radical

The metal-free C2-functionalization of chromones with alcohols and ethers via radical sp3 C–H activation was developed.

A Synthetic Method for Site‐Specific Functionalized Polypeptides: Metal‐Free, Highly Active, and Selective at Room Temperature

2020 ◽  
Vol 60 (2) ◽  
pp. 889-895
Author(s):  
Wei Zhao ◽  
Yanfeng Lv ◽  
Ji Li ◽  
Zihao Feng ◽  
Yonghao Ni ◽  
...  
Keyword(s):  
Room Temperature ◽  
Synthetic Method ◽  
Site Specific ◽  
Metal Free ◽  
Highly Active

Conjugate addition from the excited state

2018 ◽  
Vol 54 (78) ◽  
pp. 11021-11024 ◽  
Author(s):  
Akila Iyer ◽  
Sapna Ahuja ◽  
Steffen Jockusch ◽  
Angel Ugrinov ◽  
Jayaraman Sivaguru
Keyword(s):  
Excited State ◽  
Visible Light ◽  
Conjugate Addition ◽  
Metal Free

Conjugate addition occurs efficiently from excited hydrazide based acrylanilides under both UV and metal free visible light irradiations.

A mild, general, and metal-free method for site-specific deuteration induced by visible light using D2O as the source of deuterium atoms

2020 ◽  
Vol 22 (3) ◽  
pp. 669-672 ◽  
Author(s):  
Shuai Shi ◽  
Ruining Li ◽  
Liangming Rao ◽  
Zhankui Sun
Keyword(s):  
Visible Light ◽  
Functional Group ◽  
Site Specific ◽  
Metal Free ◽  
Mild Conditions ◽  
Highly Efficient ◽  
Radical Approach

Visible light induced desulfurization–deuteration method was developed using D2O as the source of deuterium atoms. This radical approach features mild conditions, broad substrate scope, highly efficient D-incorporation and excellent functional group compatibility.

Transition-Metal-Free Quinoline Synthesis from Acetophenones and Anthranils via Sequential One-Carbon Homologation/Conjugate Addition/Annulation Cascade

2017 ◽  
Vol 19 (18) ◽  
pp. 4948-4951 ◽  
Author(s):  
Sandip Balasaheb Wakade ◽  
Dipak Kumar Tiwari ◽  
Pothapragada S. K. Prabhakar Ganesh ◽  
Mandalaparthi Phanindrudu ◽  
Pravin R. Likhar ◽  
...  
Keyword(s):  
Transition Metal ◽  
Conjugate Addition ◽  
Metal Free

Peroxide-mediated site-specific C–H methylation of imidazo[1,2-a]pyridines and quinoxalin-2(1H)-ones under metal-free conditions

2020 ◽  
Vol 18 (2) ◽  
pp. 205-210 ◽  
Author(s):  
Shengzhou Jin ◽  
Hua Yao ◽  
Sen Lin ◽  
Xiaoqing You ◽  
Yao Yang ◽  
...  
Keyword(s):  
Site Specific ◽  
Metal Free

An effective approach to realize the direct methylation of imidazo[1,2-a]pyridines and quinoxalin-2(1H)-ones with peroxides under metal-free conditions is described.

scholarly journals A Synthetic Method for Site‐Specific Functionalized Polypeptides: Metal‐Free, Highly Active, and Selective at Room Temperature

2020 ◽  
Vol 133 (2) ◽  
pp. 902-908
Author(s):  
Wei Zhao ◽  
Yanfeng Lv ◽  
Ji Li ◽  
Zihao Feng ◽  
Yonghao Ni ◽  
...  
Keyword(s):  
Room Temperature ◽  
Synthetic Method ◽  
Site Specific ◽  
Metal Free ◽  
Highly Active

scholarly journals A cascade double 1,4-addition/intramolecular annulation strategy for expeditious assembly of unsymmetrical dibenzofurans

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Xinwei He ◽  
Ruxue Li ◽  
Pui Ying Choy ◽  
Mengqing Xie ◽  
Jiahui Duan ◽  
...  
Keyword(s):  
Transition Metal ◽  
Late Stage ◽  
Functional Group ◽  
Conjugate Addition ◽  
Carbon Structure ◽  
Metal Free ◽  
Air Atmosphere ◽  
Efficient Access ◽  
Synthetic Routes ◽  
Metal Catalyzed

AbstractExisting synthetic routes for accessing dibenzofuran core have intrinsic regioselectivity, limiting the substitution patterns available in heteropolycyclic arene products. Here we report a double 1,4-conjugate addition/intramolecular annulation cascade reaction between propargylamines and two equivalents of imidazolium methylides that allows efficient access of structurally versatile dibenzofurans. This transition metal-free protocol proceeds smoothly under bench-top air atmosphere and offers easy manipulation of substituents on the dibenzofuran core, and also provides good-to-excellent product yields with good functional group tolerance, particularly the –Br and –Cl groups which are often incompatible with existing metal-catalyzed C–C and/or C–O bond ring-forming processes. It is worth noting that ladder-type π-systems with all-arene quarternary carbon structure can be straightforwardly generated upon simple late-stage functionalization.

Sign in / Sign up

Export Citation Format

Share Document