Transition-Metal-Free Quinoline Synthesis from Acetophenones and Anthranils via Sequential One-Carbon Homologation/Conjugate Addition/Annulation Cascade

2017 ◽  
Vol 19 (18) ◽  
pp. 4948-4951 ◽  
Author(s):  
Sandip Balasaheb Wakade ◽  
Dipak Kumar Tiwari ◽  
Pothapragada S. K. Prabhakar Ganesh ◽  
Mandalaparthi Phanindrudu ◽  
Pravin R. Likhar ◽  
...  
Keyword(s):  
Transition Metal ◽  
Conjugate Addition ◽  
Metal Free

scholarly journals A cascade double 1,4-addition/intramolecular annulation strategy for expeditious assembly of unsymmetrical dibenzofurans

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Xinwei He ◽  
Ruxue Li ◽  
Pui Ying Choy ◽  
Mengqing Xie ◽  
Jiahui Duan ◽  
...  
Keyword(s):  
Transition Metal ◽  
Late Stage ◽  
Functional Group ◽  
Conjugate Addition ◽  
Carbon Structure ◽  
Metal Free ◽  
Air Atmosphere ◽  
Efficient Access ◽  
Synthetic Routes ◽  
Metal Catalyzed

AbstractExisting synthetic routes for accessing dibenzofuran core have intrinsic regioselectivity, limiting the substitution patterns available in heteropolycyclic arene products. Here we report a double 1,4-conjugate addition/intramolecular annulation cascade reaction between propargylamines and two equivalents of imidazolium methylides that allows efficient access of structurally versatile dibenzofurans. This transition metal-free protocol proceeds smoothly under bench-top air atmosphere and offers easy manipulation of substituents on the dibenzofuran core, and also provides good-to-excellent product yields with good functional group tolerance, particularly the –Br and –Cl groups which are often incompatible with existing metal-catalyzed C–C and/or C–O bond ring-forming processes. It is worth noting that ladder-type π-systems with all-arene quarternary carbon structure can be straightforwardly generated upon simple late-stage functionalization.

Transition-metal-free catalytic hydroboration reduction of amides to amines

2020 ◽  
Vol 7 (21) ◽  
pp. 3515-3520
Author(s):  
Wubing Yao ◽  
Jiali Wang ◽  
Aiguo Zhong ◽  
Shiliang Wang ◽  
Yinlin Shao
Keyword(s):  
Transition Metal ◽  
Selective Catalytic Reduction ◽  
Catalytic Reduction ◽  
Value Added ◽  
Metal Free

The selective catalytic reduction of amides to value-added amine products is a desirable but challenging transformation.

Deaminative carbonylative thioesterification of activated alkylamines with thiophenols under transition-metal-free conditions

2021 ◽  
Author(s):  
Fengqian Zhao ◽  
Xiao-Feng Wu
Keyword(s):  
Free Radical ◽  
Transition Metal ◽  
Metal Free

A transition-metal-free radical carbonylation of activated alkylamines with thiophenols has been successfully developed. Various thioesters were selectively produced with moderate to good yields.

Regioselective C3-H Trifluoromethylation of 2H-Indazole Under Transition-Metal-Free Photoredox Catalysis

2019 ◽  
Author(s):  
Arumugavel Murugan ◽  
Venkata Nagarjuna Babu ◽  
Nagaraj Sabarinathan ◽  
Sharada Duddu. S
Keyword(s):  
Transition Metal ◽  
Visible Light ◽  
Practical Approach ◽  
Hypervalent Iodine ◽  
Radical Mechanism ◽  
Photoredox Catalysis ◽  
Metal Free

Here we report a visible-light-promoted metal-free regioselective C3-H trifluoromehtylation reaction that proceeds via radical mechanism and which supported by control experiments. The combination of photoredox catalysis and hypervalent iodine reagent provides a practical approach for the present trifluoromethylation reaction and synthesis of a library of trifluoromethylated indazoles.

Selective Oxidation of Alcohols Catalyzed by a Transition Metal-Free System of NHPI/DDQ/NaNO2

2011 ◽  
Vol 32 (1) ◽  
pp. 118-122 ◽  
Author(s):  
Lipeng ZHOU ◽  
Chaofeng ZHANG ◽  
Tao FANG ◽  
Bingbing ZHANG ◽  
Ying WANG ◽  
...  
Keyword(s):  
Transition Metal ◽  
Selective Oxidation ◽  
Free System ◽  
Metal Free ◽  
Oxidation Of Alcohols
Sign in / Sign up

Export Citation Format

Share Document