Translocation, biotransformation-related degradation, and toxicity assessment of polyvinylpyrrolidone-modified 2H-phase nano-MoS2

Nanoscale ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 4767-4780 ◽  
Author(s):  
Linqiang Mei ◽  
Xiao Zhang ◽  
Wenyan Yin ◽  
Xinghua Dong ◽  
Zhao Guo ◽  
...  
Keyword(s):  
Toxicity Assessment

XANES and SR-TXM were used to investigate the fates of MoS2-PVP nanosheets in vivo and in vitro.

scholarly journals Toxicity Assessment of Wild Mushrooms from the Western Ghats, India: An in Vitro and Sub-Acute in Vivo Study

2018 ◽  
Vol 9 ◽  
Author(s):  
S. Sai Latha ◽  
S. Naveen ◽  
C. K. Pradeep ◽  
C. Sivaraj ◽  
M. G. Dinesh ◽  
...  
Keyword(s):  
Western Ghats ◽  
Toxicity Assessment ◽  
In Vivo Study ◽  
Wild Mushrooms ◽  
The Western Ghats

In vivo and in vitro Reproductive Toxicity Assessment of Ampicillin and Cloxacillin in Mammalian Models

2005 ◽  
Vol 2 (1) ◽  
pp. 9-14 ◽  
Author(s):  
Y. Raji . ◽  
F.O. Awobajo . ◽  
Olufadekemi . ◽  
T. Kunle-Alabi . ◽  
M.A. Gbadegesin . ◽  
...  
Keyword(s):  
Reproductive Toxicity ◽  
Toxicity Assessment

Toxicity assessment of nanoparticles in various systems and organs

2017 ◽  
Vol 6 (3) ◽  
pp. 279-289 ◽  
Author(s):  
Yuan Yang ◽  
Zhen Qin ◽  
Wei Zeng ◽  
Ting Yang ◽  
Yubin Cao ◽  
...  
Keyword(s):  
Predictive Models ◽  
Toxicity Assessment ◽  
Biological Applications ◽  
Standard Methods ◽  
Immune Systems ◽  
The Past ◽  
Injury Mechanisms ◽  
Histopathological Studies

AbstractIn the past decades, much attention has been paid to toxicity assessment of nanoparticles prior to clinical and biological applications. Whilein vitrostudies have been increasing constantly,in vivostudies of nanoparticles have not established a unified system until now. Predictive models and validated standard methods are imperative. This review summarizes the current progress in approaches assessing nanotoxicity in main systems, including the hepatic and renal, gastrointestinal, pulmonary, cardiovascular, nervous, and immune systems. Histopathological studies and specific functional examinations in each system are elucidated. Related injury mechanisms are also discussed.

Nanotoxicity Assessment: A Necessity

2020 ◽  
Vol 10 (3) ◽  
pp. 248-265
Author(s):  
Monica Joshi ◽  
Bala Prabhakar
Keyword(s):  
Cultured Cells ◽  
Toxicity Assessment ◽  
Critical Properties ◽  
The World ◽  
In Vivo Testing ◽  
In Vitro Assessment ◽  
Nano Size

Rapid growth of nanotechnology in various fields like medicine, diagnostics, biotechnology, electronics has gifted the world with products having extraordinary benefits. With increasing use of nanotechnology based products, there is a growing concern about toxicity associated with nanoparticles. Nano-size attributes unique properties to the material due to the increased surface area. But toxic effects associated with nanoparticles are also pronounced. Therefore, research in the field of nanotoxicology is of great importance. Some critical properties of nanoparticles such as chemical composition, size, shape, surface properties, purity are determinants of nanotoxicity. Thus, meticulous characterization of nanoparticles prior to toxicity assessment helps in reducing the toxicity by careful designing of nanoparticles. In vitro assessment of nanotoxicity involves testing on cultured cells whereas in vivo testing involves use of animal models like mice, rats, aquatic frogs etc. Use of predictive models like Zebrafish, Drosophila melanogaster for nanotoxicity research is increased in last few decades. Advanced methods for nanotoxicity assessment involve the use of electrochemical methods which can also give insights about mechanism of nanotoxicity. As the literature in this field is dispersed, this review collates various approaches to give a scheme for nanotoxicity evaluation right from the characterization to toxicity assessment.

scholarly journals Characteristics and toxicity assessment of electrospun gelatin/PCL nanofibrous scaffold loaded with graphene in vitro and in vivo

2019 ◽  
Vol Volume 14 ◽  
pp. 3669-3678 ◽  
Author(s):  
Xi Chen ◽  
Bei Feng ◽  
Di-Qi Zhu ◽  
Yi-Wei Chen ◽  
Wei Ji ◽  
...  
Keyword(s):  
Toxicity Assessment ◽  
Nanofibrous Scaffold ◽  
Electrospun Gelatin

Lipid-nanopotentiated combinatorial delivery of tamoxifen and sulforaphane: ex vivo, in vivo and toxicity studies

Nanomedicine ◽  
2020 ◽  
Vol 15 (26) ◽  
pp. 2563-2583 ◽  
Author(s):  
Bharti Mangla ◽  
Yub R Neupane ◽  
Archu Singh ◽  
Pankaj Kumar ◽  
Sadat Shafi ◽  
...  
Keyword(s):  
Intestinal Permeability ◽  
Oral Delivery ◽  
Chemotherapeutic Agent ◽  
Treatment Approach ◽  
Ex Vivo ◽  
Toxicity Assessment ◽  
Drug Release Profile ◽  
Novel Treatment

Aim: This study aims to load tamoxifen (TAM) and sulforaphane (SFN) into nanostructured lipid carriers (NLCs) to enhance their oral delivery. Materials & methods: TAM-SFN-NLCs were prepared using Precirol® ATO5 and Transcutol® HP, characterized and evaluated in vitro and ex vivo to assess the drug release profile and intestinal permeability, respectively. In vivo pharmacokinetic and acute toxicity assessment was performed in Wistar rats. Results: Optimized TAM-SFN-NLCs exhibited a particle size of 121.9 ± 6.42 nm and zeta potential of -21.2 ± 2.91 mV. The NLCs enhanced intestinal permeability of TAM and SFN and augmented oral bioavailability of TAM and SFN 5.2-fold and 4.8-fold, respectively. SFN significantly reduced TAM-associated toxicity in vivo. Conclusion: This coencapsulation of a chemotherapeutic agent with a herbal bioactive in NLCs could pave a novel treatment approach against cancer.

scholarly journals In vitro and in vivo toxicity assessment of nanoparticles

2017 ◽  
Vol 7 (4) ◽  
pp. 243-256 ◽  
Author(s):  
Vinay Kumar ◽  
Neha Sharma ◽  
S. S. Maitra
Keyword(s):  
Toxicity Assessment ◽  
In Vivo Toxicity
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