Capture and “self-release” of circulating tumor cells using metal–organic framework materials

Nanoscale ◽  
2019 ◽  
Vol 11 (17) ◽  
pp. 8293-8303 ◽  
Author(s):  
Wei Xie ◽  
TaiLang Yin ◽  
Yu-Ling Chen ◽  
Dao-Ming Zhu ◽  
Ming-Hui Zan ◽  
...  
Keyword(s):  
Precision Medicine ◽  
Cancer Patients ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Peripheral Blood ◽  
Metal Organic Framework ◽  
Framework Materials ◽  
Metal Organic ◽  
Organic Framework

Capturing circulating tumor cells (CTCs) from peripheral blood for subsequent analyses has shown potential in precision medicine for cancer patients.

Metal–organic frameworks for radionuclide sequestration from aqueous solution: a brief overview and outlook

2017 ◽  
Vol 46 (47) ◽  
pp. 16381-16386 ◽  
Author(s):  
Chengliang Xiao ◽  
Mark A. Silver ◽  
Shuao Wang
Keyword(s):  
Aqueous Solution ◽  
Metal Organic Framework ◽  
Metal Organic Frameworks ◽  
Framework Materials ◽  
Metal Organic ◽  
Organic Framework

137Cs, 90Sr, 238U, 79Se, and 99Tc sequestrations from aqueous solution by metal–organic framework materials are summarized in this Frontier article.

Circulating Tumor Cells in HER-2 Positive Metastatic Breast Cancer Patients Treated with Trastuzumab and Chemotherapy

2009 ◽  
Vol 24 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Raquel A. Nunes ◽  
Xiaochun Li ◽  
Soonmo Peter Kang ◽  
Harold Burstein ◽  
Lisa Roberts ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Treatment Response ◽  
Cancer Patients ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Peripheral Blood ◽  
Metastatic Breast ◽  
Breast Cancer Patients ◽  
Her 2

The detection of circulating tumor cells (CTCs) in peripheral blood may have important prognostic and predictive implications in breast cancer treatment. A limitation in this field has been the lack of a validated method of accurately measuring CTCs. While sensitivity has improved using RT-PCR, specificity remains a major challenge. The goal of this paper is to present a sensitive and specific methodology of detecting CTCs in women with HER-2-positive metastatic breast cancer, and to examine its role as a marker that tracks disease response during treatment with trastuzumab-containing regimens. The study included patients with HER-2-positive metastatic breast cancer enrolled on two different clinical protocols using a trastuzumab-containing regimen. Serial CTCs were measured at planned time points and clinical correlations were made. Immunomagnetic selection of circulating epithelial cells was used to address the specificity of tumor cell detection using cytokeratin 19 (CK19). In addition, the extracellular domain of the HER-2 protein (HER-2/ECD) was measured to determine if CTCs detected by CK19 accurately reflect tumor burden. The presence of CTCs at first restaging was associated with disease progression. We observed an association between CK19 and HER-2/ECD. The association of HER-2/ECD with clinical response followed a similar pattern to that seen with CK19. Finally, the absence of HER-2/ECD at best overall response and a change of HER-2/ECD from positive at baseline to negative at best overall response was associated with favorable treatment response. Our study supports the prognostic and predictive role of the detection of CTCs in treatment of HER-2-positive metastatic breast cancer patients. The association between CK19 and markers of disease burden is in line with the concept that CTCs may be a reliable measure of tumor cells in the peripheral blood of patients with metastatic breast cancer. The association of CTCs at first restaging with treatment failure indicates that CTCs may have a role as surrogate markers to monitor treatment response.

scholarly journals Study of van der Waals bonding and interactions in metal organic framework materials

2014 ◽  
Vol 26 (13) ◽  
pp. 133002 ◽  
Author(s):  
Sebastian Zuluaga ◽  
Pieremanuele Canepa ◽  
Kui Tan ◽  
Yves J Chabal ◽  
Timo Thonhauser
Keyword(s):  
Metal Organic Framework ◽  
Van Der Waals ◽  
Framework Materials ◽  
Metal Organic ◽  
Organic Framework

A Solvothermally in Situ Generated Mixed-ligand Approach for NLO-Active Metal−Organic Framework Materials

2005 ◽  
Vol 44 (12) ◽  
pp. 4148-4150 ◽  
Author(s):  
Yong-Tao Wang ◽  
Hai-Hua Fan ◽  
He-Zhou Wang ◽  
Xiao-Ming Chen
Keyword(s):  
Metal Organic Framework ◽  
Mixed Ligand ◽  
Framework Materials ◽  
Active Metal ◽  
Metal Organic ◽  
Organic Framework

Topology Analysis and Nonlinear-Optical-Active Properties of Luminescent Metal−Organic Framework Materials Based on Zinc/Lead Isophthalates

2008 ◽  
Vol 47 (18) ◽  
pp. 8286-8293 ◽  
Author(s):  
Lei Zhang ◽  
Ye-Yan Qin ◽  
Zhao-Ji Li ◽  
Qi-Pu Lin ◽  
Jian-Kai Cheng ◽  
...  
Keyword(s):  
Nonlinear Optical ◽  
Metal Organic Framework ◽  
Topology Analysis ◽  
Framework Materials ◽  
Metal Organic ◽  
Organic Framework
Sign in / Sign up

Export Citation Format

Share Document