Design of smart targeted and responsive drug delivery systems with enhanced antibacterial properties

Nanoscale ◽  
2018 ◽  
Vol 10 (45) ◽  
pp. 20946-20962 ◽  
Author(s):  
Hao Chen ◽  
Yingying Jin ◽  
Jingjie Wang ◽  
Yuqin Wang ◽  
Wenya Jiang ◽  
...  

The use of antibiotics has been an epoch-making invention in the past few decades for the treatment of infectious diseases.

Author(s):  
Khatereh Khorsandi ◽  
Reza Hosseinzadeh ◽  
Homa Sadat Esfahani ◽  
Saeedeh Keyvani-Ghamsari ◽  
Saeed Ur Rahman

2021 ◽  
Vol 66 ◽  
pp. 102880
Author(s):  
Bing Yang ◽  
Tian-tian Wang ◽  
Yu-shun Yang ◽  
Hai-liang Zhu ◽  
Jian-hua Li

2019 ◽  
Vol 8 (1) ◽  
pp. 548-561
Author(s):  
Tianyu Lan ◽  
Qianqian Guo

Abstract The paradigm of using phenylboronic acid-decorated polymeric nanomaterials for advanced bio-application has been well established over the past decade. Phenylboronic acid and its derivatives are known to form reversible complexes with polyols, including sugar, diol and diphenol. This unique chemistry of phenylboronic acid has given many chances to be exploited for diagnostic and therapeutic applications. This review highlights the recent advances in fabrication of phenylboronic acid-decorated polymeric nanomaterials, especially focus on the interactions with glucose and sialic acid. Applications of these phenylboronic acid-decorated nanomaterials in drug delivery systems and biosensors are discussed.


2020 ◽  
Vol 8 (31) ◽  
pp. 6517-6529 ◽  
Author(s):  
Zheng Lian ◽  
Tianjiao Ji

Representative strategies for designing smart drug delivery systems by using functional peptides in the past few years are highlighted in this review.


2016 ◽  
Vol 4 (11) ◽  
pp. 1535-1553 ◽  
Author(s):  
Arti Vashist ◽  
Ajeet Kaushik ◽  
Atul Vashist ◽  
Rahul Dev Jayant ◽  
Asahi Tomitaka ◽  
...  

Hydrogel based drug delivery systems owe excellent potential as targeted drug delivery systems for the delivery of therapeutic agents and diagnostics for major infectious diseases.


2012 ◽  
Vol 89 ◽  
pp. 248-253 ◽  
Author(s):  
Coskun Silan ◽  
Alper Akcali ◽  
Muşerref Tatman Otkun ◽  
Nilgun Ozbey ◽  
Sultan Butun ◽  
...  

Drug Delivery ◽  
2017 ◽  
pp. 349-372
Author(s):  
Maximiliano L. Cacicedo ◽  
Germán A. Islan ◽  
Pablo Gurman ◽  
Guillermo R. Castro

Author(s):  
Kallem Sharat Venkat Reddy

From the past two decades, technological advancements in science and chemistry made possible many new drug delivery systems that have the potential to completely change the course of routine therapeutic ways.  Lipid and polymer-based drug delivery systems are considered to be the pillars of many drug dosage forms, irrespective of their route of administration. With increasing knowledge on their chemistry, lipids and polymers are being modified and used as potential novel drug delivery systems with smart polymers and lipid nanotechnology paving the way for efficient drug delivery into the patient. This review article covers the swing of these drug delivery systems in the current market and interpreting all this from a health care professional’s point of view. Keywords: Gene delivery, Lipid based drug delivery, Polymer based drug delivery, Target specific drugs, Solid lipid nanoparticles


Author(s):  
Mahsa Mazdaei ◽  
Kofi Asare-Addo

The application of nanotechnology indrug delivery systems (DDS) has been researched widely and seen an advancementover the past three decades. Since the 1970s, nanoparticles were primarilyutilised in vaccine deliveries and cancer chemotherapy. In more recent years,they have been found to hold promises for broader applications such as inproteins and therapeutic gene delivery systems. To date, there have been only ahandful of nanocarrier-loaded drugs commercialised into the pharmaceuticalmarket. More research is thus needed to facilitate a breakthrough of theseproducts into the current market. This mini-review mainly focuses on four typesof commonly utilised organic nanocarriers including micelles, compactpolymerics, solid-lipid nanoparticles and liposomal vesicles and discusses theprogress and some challenges associated with these nanoparticles (NP). 


Author(s):  
Rongwei Cui ◽  
Qiang Wu ◽  
Jing Wang ◽  
Xiaoming Zheng ◽  
Rongying Ou ◽  
...  

Immunotherapy has emerged as a promising strategy for cancer treatment, in which durable immune responses were generated in patients with malignant tumors. In the past decade, biomaterials have played vital roles as smart drug delivery systems for cancer immunotherapy to achieve both enhanced therapeutic benefits and reduced side effects. Hydrogels as one of the most biocompatible and versatile biomaterials have been widely applied in localized drug delivery systems due to their unique properties, such as loadable, implantable, injectable, degradable and stimulus responsible. Herein, we have briefly summarized the recent advances on hydrogel-by-design delivery systems including the design of hydrogels and their applications for delivering of immunomodulatory molecules (e.g., cytokine, adjuvant, checkpoint inhibitor, antigen), immune cells and environmental regulatory substances in cancer immunotherapy. We have also discussed the challenges and future perspectives of hydrogels in the development of cancer immunotherapy for precision medicine at the end.


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