“Transformed” Fe3S4 tetragonal nanosheets: a high-efficiency and body-clearable agent for magnetic resonance imaging guided photothermal and chemodynamic synergistic therapy

Nanoscale ◽  
2018 ◽  
Vol 10 (37) ◽  
pp. 17902-17911 ◽  
Author(s):  
Guoqiang Guan ◽  
Xin Wang ◽  
Bo Li ◽  
Wenlong Zhang ◽  
Zhe Cui ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Side Effects ◽  
Magnetic Resonance ◽  
High Efficiency ◽  
Resonance Imaging ◽  
Body Clearance

The PVP coated Fe3S4 tetragonal nanosheets could be employed to realize magnetic resonance imaging guided photothermal/chemodynamic therapy and body-clearance without appreciable toxic side effects.

High-efficiency and safe sulfur-doped iron oxides for magnetic resonance imaging-guided photothermal/magnetic hyperthermia therapy

2020 ◽  
Vol 49 (17) ◽  
pp. 5493-5502
Author(s):  
Guoqiang Guan ◽  
Bo Li ◽  
Wenlong Zhang ◽  
Zhe Cui ◽  
Shu-Ang He ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Iron Oxides ◽  
High Efficiency ◽  
Magnetic Hyperthermia ◽  
Resonance Imaging ◽  
Highly Efficient ◽  
Hyperthermia Therapy ◽  
Body Clearance

Highly efficient body-clearance sulfur-doped iron oxides were developed for magnetic resonance imaging-guided photo-magnetic hyperthermia therapy.

Supramolecular Enhancement of Aminoxyl ORCA Contrast Agents

2019 ◽  
Author(s):  
Hamilton Lee ◽  
Jenica Lumata ◽  
Michael A. Luzuriaga ◽  
Candace Benjamin ◽  
Olivia Brohlin ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Side Effects ◽  
Magnetic Resonance ◽  
Tobacco Mosaic Virus ◽  
Contrast Agents ◽  
Single Molecule ◽  
Organic Radical ◽  
Resonance Imaging ◽  
Physiological Conditions

<div><div><div><p>Many contrast agents for magnetic resonance imaging are based on gadolinium, however side effects limit their use in some patients. Organic radical contrast agents (ORCAs) are potential alternatives, but are reduced rapidly in physiological conditions and have low relaxivities as single molecule contrast agents. Herein, we use a supramolecular strategy where cucurbit[8]uril binds with nanomolar affinities to ORCAs and protects them against biological reductants to create a stable radical in vivo. We further over came the weak contrast by conjugating this complex on the surface of a self-assembled biomacromolecule derived from the tobacco mosaic virus.</p></div></div></div>

Continuous infusion of manganese improves contrast and reduces side effects in manganese-enhanced magnetic resonance imaging studies

NeuroImage ◽  
2017 ◽  
Vol 147 ◽  
pp. 1-9 ◽  
Author(s):  
Dana S. Poole ◽  
Nathalie Doorenweerd ◽  
Jaap J. Plomp ◽  
Ahmed Mahfouz ◽  
Marcel J.T. Reinders ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Side Effects ◽  
Magnetic Resonance ◽  
Continuous Infusion ◽  
Resonance Imaging ◽  
Imaging Studies

High-efficiency laser-pumping system for magnetic resonance imaging

2000 ◽  
Author(s):  
Marziale Milani ◽  
Guido Baroni ◽  
Lorenzo Ferraro ◽  
P. Sozzani ◽  
Massimo Adobati ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
High Efficiency ◽  
Resonance Imaging ◽  
Pumping System ◽  
Laser Pumping

scholarly journals Metronidazole Induced Cerebellar Toxicity: A Case Report

2021 ◽  
Vol 59 (241) ◽  
pp. 922-924
Author(s):  
Shova Sapkota ◽  
Aliska Niroula ◽  
Rina Prajapati ◽  
Subhani Sharma ◽  
Krishna Dhungana
Keyword(s):  
Magnetic Resonance Imaging ◽  
Case Report ◽  
Peripheral Neuropathy ◽  
Side Effects ◽  
Magnetic Resonance ◽  
Liver Abscess ◽  
Imaging Findings ◽  
Resonance Imaging ◽  
Cerebellar Sign ◽  
Protozoan Infections

Metronidazole is a widely used antibiotic against bacterial and protozoan infections. Even though the therapeutic use of the drug is high, it is associated with some severe side effects like neurotoxicity such as optic neuropathy, peripheral neuropathy, encephalopathy and cerebellar toxicity. We present a case of a 55-years male presented with dysarthria, who had positive cerebellar sign and magnetic resonance imaging findings suggestive of metronidazole induced cerebellar toxicity following metronidazole therapy for two months in a case of liver abscess. And, the symptoms resolved after cessation of metronidazole.

scholarly journals Superparamagnetic Nanoparticles as High Efficiency Magnetic Resonance Imaging T2 Contrast Agent

2016 ◽  
Vol 28 (1) ◽  
pp. 161-170 ◽  
Author(s):  
Fernanda Sousa ◽  
Barbara Sanavio ◽  
Alessandra Saccani ◽  
Yun Tang ◽  
Ileana Zucca ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
High Efficiency ◽  
Superparamagnetic Nanoparticles ◽  
Resonance Imaging

Side-effects after inhalational anaesthesia for paediatric cerebral magnetic resonance imaging

2002 ◽  
Vol 12 (5) ◽  
pp. 429-437 ◽  
Author(s):  
ANDREAS SANDNER-KIESLING ◽  
GERHARD SCHWARZ ◽  
MARTIN VICENZI ◽  
ASTRID FALL ◽  
ROBERT L. JAMES ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Side Effects ◽  
Magnetic Resonance ◽  
Resonance Imaging ◽  
Cerebral Magnetic Resonance Imaging ◽  
Inhalational Anaesthesia

Comparison of Pharmaceutical Effect of Alemtuzumab and Natalizumab and Their Side Effects in Treatment of Various Stages of Multiple Sclerosis Patients.

2021 ◽  
Vol 20 ◽  
Author(s):  
Mostafa Mohammadi
Keyword(s):  
Magnetic Resonance Imaging ◽  
Multiple Sclerosis ◽  
Stem Cell ◽  
Side Effects ◽  
Magnetic Resonance ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Resonance Imaging ◽  
Hematopoietic Stem ◽  
Before And After

Background: Multiple sclerosis (MS) is an autoimmune and inflammatory disease in which the body mistakenly attacks the myelin, the sheath of nerve cells in the brain and spinal cord, causing ulcers. This damage to myelin disrupts the transmission of neural messages to the nervous system. This study aimed to compare the pharmacological effect of Alemtuzumab and Natalizumab in treating various stages of MS patients and the side effects of their use. Autologous hematopoietic stem cell transplantation has also been studied as the best current treatment for MS. Methods: In this study, 425patients with MS were examined and categorized into different groups according to their disease stages. Among the people studied, 183 were men, and 242 were women. Patients with primary progressive MS (PPMS) has divided into groups A and B, patients with relapsing-remitting MS (RRMS) in groups C and D, and patients with secondary progressive MS (SPMS) in groups E and F. According to the classification, Alemtuzumab drug prescribed for patients in groups A and C and E, and Natalizumab for B and D and E groups. To more accurately examine patients' condition, a criterion called the large-scale disability status was defined, calculated before and after treatment. Hence, the relationship between the number of head magnetic resonance imaging with the lesions created in patients, recurrence time, and recurrence rate before and after treatment investigated. Results: The EDSS the coefficient was significantly lower in RRMS patients than in PPMS and SPMS patients. After 12 months of treatment, The EDSS coefficient of RRMS patients treated with Natalizumab was significantly lower than patients treated with Alemtuzumab. Also, which was the difference between this coefficient before. Moreover, after treatment was significantly higher, Alemtuzumab, this result indicates the direct effect and a positive function of Natalizumab in this group of patients. Due to Natalizumab's use, the recurrence rate of RRMS-D was significantly lower than that of RRMS-C. After 12 months of treatment, there was a significant decrease in the lesion's number on magnetic resonance imaging of the head and the RRMS-D group time of recurrence. Conclusion: According to the results, the efficacy of Natalizumab in treating RRMS patients was better than Alemtuzumab, while there were no significant differences between other stages of MS patients. Also, the autologous hematopoietic stem cell transplantation method is more effective than Alemtuzumab and Natalizumab to use as the best treatment for patients with MS can give a theoretical and clinical guide for various stages of MS treatment and provide them to specialists.

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