scholarly journals Enhanced design and formulation of nanoparticles for anti-biofilm drug delivery

Nanoscale ◽  
2019 ◽  
Vol 11 (1) ◽  
pp. 219-236 ◽  
Author(s):  
Kenneth R. Sims ◽  
Yuan Liu ◽  
Geelsu Hwang ◽  
Hoi In Jung ◽  
Hyun Koo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Loading ◽  
Zero Order ◽  
Membrane Localization ◽  
Bacterial Membrane ◽  
Polymer Nanoparticle ◽  
Order Release ◽  
Zero Order Release ◽  
Nanoparticle Formulation

Novel polymer nanoparticle formulation improved drug loading, demonstrated zero-order release, and amplified anti-biofilm activity via increased bacterial membrane localization.

A robust nanofluidic membrane with tunable zero-order release for implantable dose specific drug delivery

Lab on a Chip ◽  
2010 ◽  
Vol 10 (22) ◽  
pp. 3074 ◽  
Author(s):  
Daniel Fine ◽  
Alessandro Grattoni ◽  
Sharath Hosali ◽  
Arturas Ziemys ◽  
Enrica De Rosa ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Zero Order ◽  
Specific Drug ◽  
Order Release ◽  
Zero Order Release

scholarly journals Drug Delivery: Sustained Zero-Order Release of Intact Ultra-Stable Drug-Loaded Liposomes from an Implantable Nanochannel Delivery System (Adv. Healthcare Mater. 2/2014)

2014 ◽  
Vol 3 (2) ◽  
pp. 153-153 ◽  
Author(s):  
Christian Celia ◽  
Silvia Ferrati ◽  
Shyam Bansal ◽  
Anne L. van de Ven ◽  
Barbara Ruozi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Delivery System ◽  
Zero Order ◽  
Order Release ◽  
Zero Order Release

Gelatin nanofiber assisted zero order release of Amphotericin-B: A study with realistic drug loading for oral formulation

2020 ◽  
Vol 24 ◽  
pp. 100953 ◽  
Author(s):  
Mrunalini Gaydhane ◽  
Pankaj Choubey ◽  
Chandra S. Sharma ◽  
Saptarshi Majumdar
Keyword(s):  
Amphotericin B ◽  
Drug Loading ◽  
Oral Formulation ◽  
Zero Order ◽  
Order Release ◽  
Zero Order Release

scholarly journals 3D Printing of Tunable Zero-Order Release Printlets

Polymers ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 1769 ◽  
Author(s):  
Fabrizio Fina ◽  
Alvaro Goyanes ◽  
Martin Rowland ◽  
Simon Gaisford ◽  
Abdul W. Basit
Keyword(s):  
3D Printing ◽  
Release Kinetics ◽  
Drug Loading ◽  
Zero Order ◽  
Prolonged Release ◽  
Fused Deposition ◽  
Order Release ◽  
Zero Order Release ◽  
3D Printed ◽  
Release Profiles

Zero-order release formulations are designed to release a drug at a constant rate over a prolonged time, thus reducing systemic side effects and improving patience adherence to the therapy. Such formulations are traditionally complex to manufacture, requiring multiple steps. In this work, fused deposition modeling (FDM) 3D printing was explored to prepare on-demand printlets (3D printed tablets). The design includes a prolonged release core surrounded by an insoluble shell able to provide zero-order release profiles. The effect of drug loading (10, 25, and 40% w/w paracetamol) on the mechanical and physical properties of the hot melt extruded filaments and 3D printed formulations was evaluated. Two different shell 3D designs (6 mm and 8 mm diameter apertures) together with three different core infills (100, 50, and 25%) were prepared. The formulations showed a range of zero-order release profiles spanning 16 to 48 h. The work has shown that with simple formulation design modifications, it is possible to print extended release formulations with tunable, zero-order release kinetics. Moreover, by using different infill percentages, the dose contained in the printlet can be infinitely adjusted, providing an additive manufacturing route for personalizing medicines to a patient.

Preparation of Melatonin-Loaded Zein Nanoparticles using Supercritical CO2 Antisolvent and in vitro Release Evaluation

2017 ◽  
Vol 13 (11) ◽  
Author(s):  
Sining Li ◽  
Yaping Zhao
Keyword(s):  
Supercritical Co2 ◽  
Drug Loading ◽  
In Vitro Release ◽  
Zero Order ◽  
Release Drug ◽  
Order Release ◽  
Zero Order Release ◽  
Release Speed ◽  
Vitro Release

Abstract In this work, we reported preparation of melatonin-loaded zein nanoparticles using the technique of solution-enhanced dispersion by supercritical CO2 (SEDS) for prolonging the release of melatonin. The influence of pressure, temperature and the ratio of melatonin and zein on the morphology, the particle size and drug loading was investigated. The release profiles of the melatonin-loaded nanoparticles were evaluated. The sizes of the most particles were less than 100 nm at most conditions examined, and the morphology had three types: rod-like, globule, and filament. The maximum drug loading of 6.9% and encapsulation efficiencies of 80.2% were obtained, respectively, under different conditions. The release speed of the melatonin in the nanoparticles is lower than both the pure one and that in the physical mixture. It displayed a near zero-order release which implied that it could be applied as a potential controlled-release drug.

Use of Microporous Accurel MP1000 for Duodenal Delivery of Secnidazole: A High Dose, Gastric pH Unstable Drug

2010 ◽  
Vol 2 (2) ◽  
Author(s):  
Amit Singh ◽  
Deepa Pathak ◽  
Kamla Pathak
Keyword(s):  
Drug Loading ◽  
Zero Order ◽  
Gastric Ph ◽  
In Vitro Dissolution ◽  
High Dose ◽  
Burst Release ◽  
Order Release ◽  
Zero Order Release ◽  
Physical Mixing

Secnidazole, a high dose antiprotozoal agent unstable at gastric pH was used as a model compound for deposition onto the adsorbent carriers by two methods namely solvent deposition and physical mixing for duodenal delivery. The drug/adsorbent systems were evaluated for pharmacotechnical properties and characterized by FT-IR, DSC, XRD, SEM and in vitro dissolution testing to investigate the influence of carriers and methods of preparation on in vitro drug release. The solvent deposited secnidazole adsorbates (F4-F6) with high drug loading capacity and better control on dissolution at all time points were subjected to modified release by encapsulating in formaldehyde treated PVP K40 coated capsules. The optimized formulation was able to maintain zero order release with a maximum release of 95.91% at the end of 8 h in contrast to marketed formulation that gave a burst release of 67.89% within 2.5 hours followed by a non zero order release of 87.89% at the end of fifth hour. Thus a formulation of secnidazole accurel adsorbates could be developed that when suitably designed provided controlled duodenal delivery.

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