Zero-Order Release Kinetics from a Self-Correcting Floatable Asymmetric Configuration Drug Delivery System

1996 ◽  
Vol 85 (2) ◽  
pp. 170-173 ◽  
Author(s):  
Libo Yang ◽  
Reza Fassihi
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Release Kinetics ◽  
Zero Order ◽  
Order Release ◽  
Zero Order Release ◽  
Asymmetric Configuration

scholarly journals Drug Delivery: Sustained Zero-Order Release of Intact Ultra-Stable Drug-Loaded Liposomes from an Implantable Nanochannel Delivery System (Adv. Healthcare Mater. 2/2014)

2014 ◽  
Vol 3 (2) ◽  
pp. 153-153 ◽  
Author(s):  
Christian Celia ◽  
Silvia Ferrati ◽  
Shyam Bansal ◽  
Anne L. van de Ven ◽  
Barbara Ruozi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Delivery System ◽  
Zero Order ◽  
Order Release ◽  
Zero Order Release

scholarly journals Formulation and evaluation of multiple tablets as a biphasic gastroretentive floating drug delivery system for fenoverine

2010 ◽  
Vol 60 (1) ◽  
pp. 89-97 ◽  
Author(s):  
Suresh Bandari ◽  
Chandra Eaga ◽  
Ashok Thadishetty ◽  
Madhusudan Yamsani
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Release Kinetics ◽  
Matrix Tablet ◽  
Compression Process ◽  
Floating Drug Delivery ◽  
Zero Order Release ◽  
Floating Drug Delivery System ◽  
Dose Tablet

Formulation and evaluation of multiple tablets as a biphasic gastroretentive floating drug delivery system for fenoverineA biphasic gastroretentive drug delivery system of fenoverine was developed to maintain constant plasma concentration. The delivery system consisted of a loading-dose tablet and a floating multiple matrix tablet prepared by the direct compression process. The drug release from biphasic GRDDS in 0.1 mol L-1HCl and SGF (enzyme free) was sustained over 12 h with buoyant properties. Stability studies showed no significant change in dissolution profiles (f2 value > 50). Based on the release kinetics, it can be concluded that the floating multiple matrix tablet containing HPMC was a particularly suitable gastroretentive drug delivery system with a zero-order release profile.

RESEALED ERYTHROCYTES: A PROMISING APPROACH TO ENHANCE EFFICACY OF ANTICANCER DRUGS

INDIAN DRUGS ◽  
2020 ◽  
Vol 57 (03) ◽  
pp. 9-20
Author(s):  
◽  
Prathibha Salve ◽  
Rajendra Doijad ◽  
Niranjan Chivate
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Anticancer Drugs ◽  
Delivery System ◽  
Release Kinetics ◽  
Drug Loading ◽  
The Body ◽  
Zero Order Release

Targeted drug delivery system is a potential drug delivery system which delivers the drug to particular organ of interest only. This improves the therapeutic efficacy of the treatment by reducing the side effects of drug which are required in case of anticancer drugs. Erythrocytes have been the most interesting carrier and have found to possess great potential in drug targeting. Resealed erythrocytes are gaining more popularity because of their ability to circulate throughout the body, biocompatibility, zero order release kinetics, reproducibility and ease of preparation. In this review, we have made an attempt to understand the process in detail to prepare resealed erythrocytes, including its mechanism, source and isolation of erythrocytes, methods of drug loading, in vivo and in vitro characterization of resealed erythrocytes, with special emphasis on applications of resealed erythrocytes for cancer treatment. With this review we can conclude that resealed erythrocyte is a promising approach to enhance efficacy of anticancer drugs.

Strontium modified biocements with zero order release kinetics

Biomaterials ◽  
2008 ◽  
Vol 29 (35) ◽  
pp. 4691-4697 ◽  
Author(s):  
Mohammad Hamdan Alkhraisat ◽  
Claus Moseke ◽  
Luis Blanco ◽  
Jake E. Barralet ◽  
Enrique Lopez-Carbacos ◽  
...  
Keyword(s):  
Release Kinetics ◽  
Zero Order ◽  
Order Release ◽  
Zero Order Release

A robust nanofluidic membrane with tunable zero-order release for implantable dose specific drug delivery

Lab on a Chip ◽  
2010 ◽  
Vol 10 (22) ◽  
pp. 3074 ◽  
Author(s):  
Daniel Fine ◽  
Alessandro Grattoni ◽  
Sharath Hosali ◽  
Arturas Ziemys ◽  
Enrica De Rosa ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Zero Order ◽  
Specific Drug ◽  
Order Release ◽  
Zero Order Release

scholarly journals QbD-Based Development and Evaluation of Time-dependent Chronopharmaceutical Drug Delivery System of Amoxicillin Trihydrate for Management of Bacterial Infection

2018 ◽  
Vol 10 (03) ◽  
Author(s):  
Shyam Narayan Prasad ◽  
Ashok Kumar Sahoo ◽  
Abhijit V. Gothoskar
Keyword(s):  
Drug Delivery ◽  
Bacterial Infection ◽  
Drug Delivery System ◽  
Delivery System ◽  
Bacterial Infections ◽  
Release Kinetics ◽  
Matrix Tablets ◽  
Critical Material ◽  
Amoxicillin Trihydrate

The present studies discuss about the quality by design (QbD)-based development and evaluation of chronomodulated release drug delivery system of amoxicillin trihydrate for management of bacterial infection. Initially, target product profile was defined and critical quality attributes were earmarked. Risk assessment study was performed for identifying the critical material attributes. Preformulation studies were carried out, and direct compression method was employed for the preparation of bilayer matrix tablets containing a delayed and a sustained release layer for preliminary optimization. Systematic formulation optimization was carried out using central composite design by selecting the concentration of Eudragit-L100 D55 and HPMCK4M. Mathematical modeling was performed and optimized compositions of the polymers were identified from the design space. Moreover, the prepared bilayer tablets were evaluated for various tablet properties including in vitro drug release study, release kinetics evaluation and characterized for FTIR, DSC, XRD, SEM studies, in vitro was-off test, antimicrobial assay and accelerated stability studies. In a nutshell, the present studies indicated the supremacy of designing a chronomodulated release bilayer tablet formulations of amoxicillin trihydrate for effective management of bacterial infections.

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