Targeted imaging of the lysosome and endoplasmic reticulum and their pH monitoring with surface regulated carbon dots

Nanoscale ◽  
2018 ◽  
Vol 10 (26) ◽  
pp. 12788-12796 ◽  
Author(s):  
Shuang E ◽  
Quan-Xing Mao ◽  
Xiao-Li Yuan ◽  
Xiao-Lei Kong ◽  
Xu-Wei Chen ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Cellular Uptake ◽  
Carbon Dots ◽  
Ph Monitoring ◽  
Targeted Imaging ◽  
Amine Group ◽  
Surface Chemistries

Amine group functionalized CDs (ACDs) and laurylamine functionalized CDs (LCDs) are prepared and adopted for the targeted imaging of lysosomes and the endoplasmic reticulum, attributed to their individual surface chemistries and cellular uptake pathways.

Cetuximab-conjugated iodine doped carbon dots as a dual fluorescent/CT probe for targeted imaging of lung cancer cells

2018 ◽  
Vol 170 ◽  
pp. 194-200 ◽  
Author(s):  
Huifang Su ◽  
Ying Liao ◽  
Fengshou Wu ◽  
Xinzhi Sun ◽  
Hongjian Liu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Carbon Dots ◽  
Lung Cancer Cells ◽  
Targeted Imaging ◽  
Doped Carbon Dots

scholarly journals Tumor-acidity activated surface charge conversion of two-photon fluorescent nanoprobe for enhanced cellular uptake and targeted imaging of intracellular hydrogen peroxide

2019 ◽  
Vol 10 (40) ◽  
pp. 9351-9357 ◽  
Author(s):  
Lanlan Chen ◽  
Shuai Xu ◽  
Wei Li ◽  
Tianbing Ren ◽  
Lin Yuan ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Surface Charge ◽  
Cellular Uptake ◽  
Targeted Imaging ◽  
Two Photon ◽  
Fluorescent Nanoprobe ◽  
Tumor Acidity ◽  
Ph Dependent ◽  
Intracellular Hydrogen Peroxide ◽  
Activated Surface

A smart, two-photon fluorescent GC–NABP nanoprobe with pH-dependent surface charge conversion was developed for tumor-targeted visualization of H2O2.

Methotrexate anchored carbon dots as theranostic probes: digitonin conjugation enhances cellular uptake and cytotoxicity

RSC Advances ◽  
2016 ◽  
Vol 6 (61) ◽  
pp. 56313-56318 ◽  
Author(s):  
A. Shanti Krishna ◽  
C. Radhakumary ◽  
S. S. Priya ◽  
Rekha M. Ramesan ◽  
K. Sreenivasan
Keyword(s):  
Cellular Uptake ◽  
Carbon Dots

Digitonin conjugation significantly improves the theranostic potential of methotrexate amended carbon dots.

Dual-functional carbon dots–silver@zinc oxide nanocomposite: in vitro evaluation of cellular uptake and induction of apoptosis

2015 ◽  
Vol 3 (7) ◽  
pp. 1217-1229 ◽  
Author(s):  
Abhay Sachdev ◽  
Ishita Matai ◽  
P. Gopinath
Keyword(s):  
Zinc Oxide ◽  
Cellular Uptake ◽  
Carbon Dots ◽  
In Vitro Evaluation ◽  
Dual Functional ◽  
Induction Of Apoptosis

We report here the devleopment of novel CDs decorated on a silver–zinc oxide (CD–Ag@ZnO) nanocomposite (NC) consisting of highly fluorescent CDs and Ag@ZnO.

scholarly journals Controlling Nanoemulsion Surface Chemistry with Poly(2-Oxazoline) Amphiphiles

2018 ◽  
Author(s):  
Daniel A. Estabrook ◽  
Amanda F. Ennis ◽  
Rachael Day ◽  
Ellen Sletten
Keyword(s):  
Block Copolymers ◽  
Surface Chemistry ◽  
Physicochemical Properties ◽  
Cellular Uptake ◽  
Surface Functionalization ◽  
Covalent Modification ◽  
Dynamic Materials ◽  
Structure Activity ◽  
Modified Surface ◽  
Surface Chemistries

Emulsions are dynamic materials that have been extensively employed within pharmaceutical, food and cosmetics industries. However, their use beyond conventional applications has been hindered by difficulties in surface functionalization, and an inability to selectively control physicochemical properties. Here, we employ custom poly(2-oxazoline) block copolymers to overcome these limitations. We demonstrate that poly(2-oxazoline) copolymers can effectively stabilize nanoscale droplets of hydrocarbon and perfluorocarbon in water. The living polymerization allows for the incorporation of chemical handles into the surfactants such that covalent modification of the emulsion surfaces can be performed. Through post-emulsion modification, we are able to access nanoemulsions with modified surface chemistries, yet consistent sizes. By decoupling size and surface charge, we explore structure-activity relationships involving the cellular uptake of nanoemulsions.

Carbon dots with tunable dual emissions: from the mechanism to the specific imaging of endoplasmic reticulum polarity

Nanoscale ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 6852-6860 ◽  
Author(s):  
E. Shuang ◽  
Quan-Xing Mao ◽  
Jian-Hua Wang ◽  
Xu-Wei Chen
Keyword(s):  
Endoplasmic Reticulum ◽  
Carbon Dots ◽  
Dual Emission ◽  
Dual Emissions

Regulating the fluorescence of carbon dots (CDs) is important but highly challenging. This work develops a facile approach to fabricate CDs with tunable dual-emission by modulating the polymerization and carbonization processes of precursors.

scholarly journals A ratiometric fluorescent probe for pH detection based on Ag 2 S quantum dots–carbon dots nanohybrids

2020 ◽  
Vol 7 (7) ◽  
pp. 200482
Author(s):  
Xiaoxue Lei ◽  
Yiying Fu ◽  
Yuan Wu ◽  
Lu Chen ◽  
Jiangong Liang
Keyword(s):  
Quantum Dots ◽  
Carbon Dots ◽  
Ph Monitoring ◽  
Excitation Wavelength ◽  
Ph Sensing ◽  
Internal Reference ◽  
One Pot ◽  
Dual Emission ◽  
Ph Variation ◽  
Green Fluorescent

In this study, a novel ratiometric fluorescent nanoprobe for pH monitoring has been developed by synthesizing red fluorescent Ag 2 S quantum dots (Ag 2 S QDs) and green fluorescent carbon dots (CDs) nanohybrids (Ag 2 S CDs) in one pot using CDs as templates. The nanoprobe exhibits dual-emission peaks at 500 and 670 nm under a single-excitation wavelength of 450 nm. The red fluorescence can be selectively quenched by increasing pH, while the green fluorescence is an internal reference. Therefore, the change of the relative fluorescence intensity (I 500 /I 670 ) in the ratiometric Ag 2 S CDs probes can be used for pH sensing. The results revealed that I 500 /I 670 of Ag 2 S CDs probes was linearly related to pH variation between pH 5.4 and 6.8. Meanwhile, the Ag 2 S CDs probes possessed a good reversibility along with pH changing between 5.0 and 7.0 without any interruption from common metal ions, proteins and other interferences.

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