Methotrexate anchored carbon dots as theranostic probes: digitonin conjugation enhances cellular uptake and cytotoxicity

RSC Advances ◽  
2016 ◽  
Vol 6 (61) ◽  
pp. 56313-56318 ◽  
Author(s):  
A. Shanti Krishna ◽  
C. Radhakumary ◽  
S. S. Priya ◽  
Rekha M. Ramesan ◽  
K. Sreenivasan
Keyword(s):  
Cellular Uptake ◽  
Carbon Dots

Digitonin conjugation significantly improves the theranostic potential of methotrexate amended carbon dots.

Dual-functional carbon dots–silver@zinc oxide nanocomposite: in vitro evaluation of cellular uptake and induction of apoptosis

2015 ◽  
Vol 3 (7) ◽  
pp. 1217-1229 ◽  
Author(s):  
Abhay Sachdev ◽  
Ishita Matai ◽  
P. Gopinath
Keyword(s):  
Zinc Oxide ◽  
Cellular Uptake ◽  
Carbon Dots ◽  
In Vitro Evaluation ◽  
Dual Functional ◽  
Induction Of Apoptosis

We report here the devleopment of novel CDs decorated on a silver–zinc oxide (CD–Ag@ZnO) nanocomposite (NC) consisting of highly fluorescent CDs and Ag@ZnO.

Rational Design of Surface-State Controlled Multicolor Cross-Linked Carbon Dots with Distinct Photoluminescence and Cellular Uptake Properties

2021 ◽  
Author(s):  
Indrajit Srivastava ◽  
Parikshit Moitra ◽  
Muhammad Fayyaz ◽  
Subhendu Pandit ◽  
Taylor L. Kampert ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Surface State ◽  
Carbon Dots ◽  
Rational Design

The effect of surface charge on cellular uptake and inflammatory behavior of carbon dots

2020 ◽  
Vol 35 ◽  
pp. 100243 ◽  
Author(s):  
Muhammad Usman ◽  
Yumna Zaheer ◽  
Muhammad Rizwan Younis ◽  
Ruken Esra Demirdogen ◽  
Syed Zajif Hussain ◽  
...  
Keyword(s):  
Surface Charge ◽  
Cellular Uptake ◽  
Carbon Dots ◽  
Effect Of Surface

Targeted imaging of the lysosome and endoplasmic reticulum and their pH monitoring with surface regulated carbon dots

Nanoscale ◽  
2018 ◽  
Vol 10 (26) ◽  
pp. 12788-12796 ◽  
Author(s):  
Shuang E ◽  
Quan-Xing Mao ◽  
Xiao-Li Yuan ◽  
Xiao-Lei Kong ◽  
Xu-Wei Chen ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Cellular Uptake ◽  
Carbon Dots ◽  
Ph Monitoring ◽  
Targeted Imaging ◽  
Amine Group ◽  
Surface Chemistries

Amine group functionalized CDs (ACDs) and laurylamine functionalized CDs (LCDs) are prepared and adopted for the targeted imaging of lysosomes and the endoplasmic reticulum, attributed to their individual surface chemistries and cellular uptake pathways.

Water-soluble amphiphilic ruthenium(ii) polypyridyl complexes as potential light-activated therapeutic agents

2020 ◽  
Vol 56 (65) ◽  
pp. 9332-9335
Author(s):  
Sandra Estalayo-Adrián ◽  
Salvador Blasco ◽  
Sandra A. Bright ◽  
Gavin J. McManus ◽  
Guillermo Orellana ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Cells ◽  
Cellular Uptake ◽  
Therapeutic Agents ◽  
Water Soluble ◽  
Polypyridyl Complexes ◽  
Cervical Cancer Cells

Two new water-soluble amphiphilic Ru(ii) polypyridyl complexes were synthesised and their photophysical and photobiological properties evaluated; both complexes showed a rapid cellular uptake and phototoxicity against HeLa cervical cancer cells.

Die Anämie bei malignen Tumorerkrankungen

1989 ◽  
Vol 28 (05) ◽  
pp. 193-200 ◽  
Author(s):  
E. Aulbert
Keyword(s):  
Cellular Uptake ◽  
Tumor Tissue ◽  
Malignant Tumors ◽  
The Other ◽  
Novikoff Hepatoma ◽  
Cellular Accumulation ◽  
Tumor Mass ◽  
Proliferation Activity ◽  
Morris Hepatoma ◽  
Cellular Incorporation

Cellular uptake of 67Ga-labelled transferrin by the tumor tissue was studied in rats with tumors of different malignancy and different tumor mass using the slowly growing Morris hepatoma 5123C, the moderately growing Novikoff hepatoma and the very fast and aggressive Yoshida hepatoma AH130. The cellular accumulation of 67Ga-transferrin was found to correlate with the proliferation activity of the tumor. The 67Ga-transferrin concentration in the very fast growing Yoshida hepatoma was 4.8 times higher than the concentration in the slowly growing Morris hepatoma. The uptake of 67Ga-transferrin by the tumors resulted in a faster disappearance of circulating 67Ga-transferrin from the blood. The rate of disappearance correlated with the proliferation activity and the spread of the tumors. Using tumors of identical size the elimination of 67Ga-transferrin from the blood was much faster in the rats with Yoshida hepatoma than in those with the slowly growing Morris hepatoma. On the other hand, using tumors of different tumor size it could be demonstrated that the rate of disappearance of 67Ga-transferrin from the blood correlated directly with tumor mass. It is concluded that cellular incorporation of transferrin within the tumor cells results in a loss of circulating transferrin, which correlates with tumor mass and proliferation of tumor. This mechanism is supposed to be the cause for the hypotransferrinemia seen in patients with malignant tumors.

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