Magnetic nanoparticle-containing soft–hard diblock copolymer films with high order

Nanoscale ◽  
2018 ◽  
Vol 10 (25) ◽  
pp. 11930-11941 ◽  
Author(s):  
Senlin Xia ◽  
Lin Song ◽  
Volker Körstgens ◽  
Matthias Opel ◽  
Matthias Schwartzkopf ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
External Field ◽  
Diblock Copolymer ◽  
Magnetic Nanoparticle ◽  
High Order ◽  
Sensor Applications ◽  
Copolymer Films

For sensor applications, superparamagnetic anisotropy is an indispensable property, which is typically achieved by employing an external field to guide the arrangement of magnetic nanoparticles (NPs).

Nanostructured diblock copolymer films with embedded magnetic nanoparticles

2011 ◽  
Vol 23 (25) ◽  
pp. 254203 ◽  
Author(s):  
Xin Xia ◽  
Ezzeldin Metwalli ◽  
Matthias A Ruderer ◽  
Volker Körstgens ◽  
Peter Busch ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Diblock Copolymer ◽  
Copolymer Films

scholarly journals Incorporation of magnetic nanoparticles into lamellar polystyrene-b-poly(n-butyl methacrylate) diblock copolymer films: Influence of the chain end-groups on nanostructuration

Polymer ◽  
2010 ◽  
Vol 51 (21) ◽  
pp. 4673-4685 ◽  
Author(s):  
Siham Douadi-Masrouki ◽  
Bruno Frka-Petesic ◽  
Maud Save ◽  
Bernadette Charleux ◽  
Valérie Cabuil ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Diblock Copolymer ◽  
Butyl Methacrylate ◽  
Copolymer Films ◽  
End Groups

Self-Assembly of Large Magnetic Nanoparticles in Ultrahigh Molecular Weight Linear Diblock Copolymer Films

2020 ◽  
Vol 12 (6) ◽  
pp. 7557-7564 ◽  
Author(s):  
Wei Cao ◽  
Senlin Xia ◽  
Xinyu Jiang ◽  
Michael Appold ◽  
Matthias Opel ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Magnetic Nanoparticles ◽  
Diblock Copolymer ◽  
Self Assembly ◽  
Copolymer Films ◽  
Ultrahigh Molecular Weight

scholarly journals Understanding intracellular nanoparticle trafficking fates through spatiotemporally resolved magnetic nanoparticle recovery

2021 ◽  
Author(s):  
Emily Sheridan ◽  
Silvia Vercellino ◽  
Lorenzo Cursi ◽  
Laurent Adumeau ◽  
James A. Behan ◽  
...  
Keyword(s):  
Decision Making ◽  
Magnetic Nanoparticles ◽  
Magnetic Nanoparticle ◽  
Magnetic Extraction

We describe how magnetic nanoparticles can be used to study intracellular nanoparticle trafficking, and how magnetic extraction may be integrated with downstream analyses to investigate nanoscale decision-making events.

scholarly journals Therapeutic Potential of Magnetic Nanoparticle-Based Human Adipose-Derived Stem Cells in a Mouse Model of Parkinson’s Disease

2021 ◽  
Vol 22 (2) ◽  
pp. 654
Author(s):  
Ka Young Kim ◽  
Keun-A Chang
Keyword(s):  
Parkinson’S Disease ◽  
Stem Cells ◽  
Parkinson's Disease ◽  
Magnetic Nanoparticles ◽  
Substantia Nigra ◽  
Mouse Model ◽  
Magnetic Nanoparticle ◽  
Imaging System ◽  
Therapeutic Potential ◽  
Adipose Derived Stem Cells

Parkinson’s disease (PD) is a progressive neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra. Several treatments for PD have focused on the management of physical symptoms using dopaminergic agents. However, these treatments induce various adverse effects, including hallucinations and cognitive impairment, owing to non-targeted brain delivery, while alleviating motor symptoms. Furthermore, these therapies are not considered ultimate cures owing to limited brain self-repair and regeneration abilities. In the present study, we aimed to investigate the therapeutic potential of human adipose-derived stem cells (hASCs) using magnetic nanoparticles in a 6-hydroxydopamine (6-OHDA)-induced PD mouse model. We used the Maestro imaging system and magnetic resonance imaging (MRI) for in vivo tracking after transplantation of magnetic nanoparticle-loaded hASCs to the PD mouse model. The Maestro imaging system revealed strong hASCs signals in the brains of PD model mice. In particular, MRI revealed hASCs distribution in the substantia nigra of hASCs-injected PD mice. Behavioral evaluations, including apomorphine-induced rotation and rotarod performance, were significantly recovered in hASCs-injected 6-OHDA induced PD mice when compared with saline-treated counterparts. Herein, we investigated whether hASCs transplantation using magnetic nanoparticles recovered motor functions through targeted brain distribution in a 6-OHDA induced PD mice. These results indicate that magnetic nanoparticle-based hASCs transplantation could be a potential therapeutic strategy in PD.

Simulated Clustering Dynamics of Colloidal Magnetic Nanoparticles

Nanoscale ◽  
2021 ◽  
Author(s):  
Frederik Laust Durhuus ◽  
Lau Halkier Wandall ◽  
Mathias Hoeg Boisen ◽  
Mathias Kure ◽  
Marco Beleggia ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Self Assembly ◽  
Biomedical Applications ◽  
Magnetic Nanoparticle ◽  
Bottom Up ◽  
Novel Materials ◽  
Nanoparticle Clusters ◽  
Clustering Dynamics

Magnetically guided self-assembly of nanoparticles is a promising bottom-up method to fabricate novel materials and superstructures, such as, for example, magnetic nanoparticle clusters for biomedical applications. The existence of assembled...

scholarly journals Transient cell stiffening triggered by magnetic nanoparticle exposure

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Jose E. Perez ◽  
Florian Fage ◽  
David Pereira ◽  
Ali Abou-Hassan ◽  
Sophie Asnacios ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Magnetic Nanoparticles ◽  
Magnetic Nanoparticle ◽  
Early Time ◽  
Population Level ◽  
Short Time Scale ◽  
Initial Contact ◽  
Almost All ◽  
The Impact ◽  
Stiffening Effect

Abstract Background The interactions between nanoparticles and the biological environment have long been studied, with toxicological assays being the most common experimental route. In parallel, recent growing evidence has brought into light the important role that cell mechanics play in numerous cell biological processes. However, despite the prevalence of nanotechnology applications in biology, and in particular the increased use of magnetic nanoparticles for cell therapy and imaging, the impact of nanoparticles on the cells’ mechanical properties remains poorly understood. Results Here, we used a parallel plate rheometer to measure the impact of magnetic nanoparticles on the viscoelastic modulus G*(f) of individual cells. We show how the active uptake of nanoparticles translates into cell stiffening in a short time scale (< 30 min), at the single cell level. The cell stiffening effect is however less marked at the cell population level, when the cells are pre-labeled under a longer incubation time (2 h) with nanoparticles. 24 h later, the stiffening effect is no more present. Imaging of the nanoparticle uptake reveals almost immediate (within minutes) nanoparticle aggregation at the cell membrane, triggering early endocytosis, whereas nanoparticles are almost all confined in late or lysosomal endosomes after 2 h of uptake. Remarkably, this correlates well with the imaging of the actin cytoskeleton, with actin bundling being highly prevalent at early time points into the exposure to the nanoparticles, an effect that renormalizes after longer periods. Conclusions Overall, this work evidences that magnetic nanoparticle internalization, coupled to cytoskeleton remodeling, contributes to a change in the cell mechanical properties within minutes of their initial contact, leading to an increase in cell rigidity. This effect appears to be transient, reduced after hours and disappearing 24 h after the internalization has taken place.

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