Diagnosis of immunomarkersin vivo viamultiplexed surface enhanced Raman spectroscopy with gold nanostars

Nanoscale ◽  
2018 ◽  
Vol 10 (27) ◽  
pp. 13092-13105 ◽  
Author(s):  
Yu-Chuan Ou ◽  
Joseph A. Webb ◽  
Christine M. O'Brien ◽  
Isaac J. Pence ◽  
Eugene C. Lin ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Ex Vivo ◽  
Surface Enhanced Raman Spectroscopy ◽  
Gold Nanostars ◽  
Mouse Tumors ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

In this work biomarkers PD-L1 and EGFR are diagnosed in mouse tumorsin vivoandex vivowith surface-enhanced Raman spectroscopy.

scholarly journals Surface-Enhanced Raman Spectroscopy for Cancer Immunotherapy Applications: Opportunities, Challenges, and Current Progress in Nanomaterial Strategies

Nanomaterials ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 1145 ◽  
Author(s):  
Shuvashis Dey ◽  
Matt Trau ◽  
Kevin M. Koo
Keyword(s):  
Raman Spectroscopy ◽  
Cancer Immunotherapy ◽  
Immune Checkpoint ◽  
Checkpoint Inhibitors ◽  
Surface Enhanced Raman Spectroscopy ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Checkpoint Receptors

Cancer immunotherapy encompasses a variety of approaches which target or use a patient’s immune system components to eliminate cancer. Notably, the current use of immune checkpoint inhibitors to target immune checkpoint receptors such as CTLA-4 or PD-1 has led to remarkable treatment responses in a variety of cancers. To predict cancer patients’ immunotherapy responses effectively and efficiently, multiplexed immunoassays have been shown to be advantageous in sensing multiple immunomarkers of the tumor microenvironment simultaneously for patient stratification. Surface-enhanced Raman spectroscopy (SERS) is well-regarded for its capabilities in multiplexed bioassays and has been increasingly demonstrated in cancer immunotherapy applications in recent years. This review focuses on SERS-active nanomaterials in the modern literature which have shown promise for enabling cancer patient-tailored immunotherapies, including multiplexed in vitro and in vivo immunomarker sensing and imaging, as well as immunotherapy drug screening and delivery.

Rapid Detection of Carbapenemase-Producing Enterobacteriacae Based on Surface-Enhanced Raman Spectroscopy with Gold Nanostars

2020 ◽  
Vol 6 (5) ◽  
pp. 947-953 ◽  
Author(s):  
Yen Lynn Wong ◽  
Wei Cherng Malvin Kang ◽  
Miguel Reyes ◽  
Jeanette Woon Pei Teo ◽  
James Chen Yong Kah
Keyword(s):  
Raman Spectroscopy ◽  
Rapid Detection ◽  
Surface Enhanced Raman Spectroscopy ◽  
Gold Nanostars ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

scholarly journals Surface-enhanced Raman spectroscopy for in vivo biosensing

2017 ◽  
Vol 1 (8) ◽  
Author(s):  
Stacey Laing ◽  
Lauren E. Jamieson ◽  
Karen Faulds ◽  
Duncan Graham
Keyword(s):  
Raman Spectroscopy ◽  
Surface Enhanced Raman Spectroscopy ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

Synthesis and characterisation of dual plasmonic gold nanostars as high‐performance surface‐enhanced Raman spectroscopy substrate

2016 ◽  
Vol 11 (11) ◽  
pp. 769-774 ◽  
Author(s):  
Vijay Raghavan ◽  
Hai Ming Fan ◽  
Eoin K. McCarthy ◽  
Peter Dockery ◽  
Antony Wheatley ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
High Performance ◽  
Surface Enhanced Raman Spectroscopy ◽  
Gold Nanostars ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Performance Surface

Spiers Memorial Lecture : Surface-enhanced Raman spectroscopy: from single particle/molecule spectroscopy to ångstrom-scale spatial resolution and femtosecond time resolution

2017 ◽  
Vol 205 ◽  
pp. 9-30 ◽  
Author(s):  
Anne-Isabelle Henry ◽  
Tyler W. Ueltschi ◽  
Michael O. McAnally ◽  
Richard P. Van Duyne
Keyword(s):  
Raman Spectroscopy ◽  
Spatial Resolution ◽  
Single Molecule ◽  
Time Resolution ◽  
Glucose Sensor ◽  
Surface Enhanced Raman Spectroscopy ◽  
Memorial Lecture ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

Four decades on, surface-enhanced Raman spectroscopy (SERS) continues to be a vibrant field of research that is growing (approximately) exponentially in scope and applicability while pushing at the ultimate limits of sensitivity, spatial resolution, and time resolution. This introductory paper discusses some aspects related to all four of the themes for this Faraday Discussion. First, the wavelength-scanned SERS excitation spectroscopy (WS-SERES) of single nanosphere oligomers (viz., dimers, trimers, etc.), the distance dependence of SERS, the magnitude of the chemical enhancement mechanism, and the progress toward developing surface-enhanced femtosecond stimulated Raman spectroscopy (SE-FSRS) are discussed. Second, our efforts to develop a continuous, minimally invasive, in vivo glucose sensor based on SERS are highlighted. Third, some aspects of our recent work in single molecule SERS and the translation of that effort to ångstrom-scale spatial resolution in ultrahigh vacuum tip-enhanced Raman spectroscopy (UHV-TERS) and single molecule electrochemistry using electrochemical (EC)-TERS will be presented. Finally, we provide an overview of analytical SERS with our viewpoints on SERS substrates, approaches to address the analyte generality problem (i.e. target molecules that do not spontaneously adsorb and/or have Raman cross sections <10−29 cm2 sr−1), SERS for catalysis, and deep UV-SERS.

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