Amaryllidaceae andSceletiumalkaloids

2019 ◽  
Vol 36 (10) ◽  
pp. 1462-1488 ◽  
Author(s):  
Zhong Jin ◽  
Guangmin Yao
Keyword(s):  
Biological Activity ◽  
Recent Progress ◽  
Amaryllidaceae Alkaloids ◽  
Synthetic Studies

Recent progress on the isolation, identification, biological activity and synthetic studies of Amaryllidaceae alkaloids, as well as the structurally close alkaloids from theSceletiumgenus, published from July 2015 to June 2017 are reviewed.

scholarly journals Recent Progress on Biological Activity of Amaryllidaceae and Further Isoquinoline Alkaloids in Connection with Alzheimer’s Disease

Molecules ◽  
2021 ◽  
Vol 26 (17) ◽  
pp. 5240
Author(s):  
Lucie Cahlíková ◽  
Rudolf Vrabec ◽  
Filip Pidaný ◽  
Rozálie Peřinová ◽  
Negar Maafi ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Biological Activity ◽  
Life Expectancy ◽  
Neurodegenerative Disease ◽  
Elderly People ◽  
Recent Progress ◽  
Isoquinoline Alkaloids ◽  
Amaryllidaceae Alkaloids ◽  
Age Related

Alzheimer’s disease (AD) is a progressive age-related neurodegenerative disease recognized as the most common form of dementia among elderly people. Due to the fact that the exact pathogenesis of AD still remains to be fully elucidated, the treatment is only symptomatic and available drugs are not able to modify AD progression. Considering the increase in life expectancy worldwide, AD rates are predicted to increase enormously, and thus the search for new AD drugs is urgently needed. Due to their complex nitrogen-containing structures, alkaloids are considered to be promising candidates for use in the treatment of AD. Since the introduction of galanthamine as an antidementia drug in 2001, Amaryllidaceae alkaloids (AAs) and further isoquinoline alkaloids (IAs) have been one of the most studied groups of alkaloids. In the last few years, several compounds of new structure types have been isolated and evaluated for their biological activity connected with AD. The present review aims to comprehensively summarize recent progress on AAs and IAs since 2010 up to June 2021 as potential drugs for the treatment of AD.

Correct Disulfide Pairing Is Required for the Biological Activity of Crustacean Androgenic Gland Hormone (AGH): Synthetic Studies of AGH

Biochemistry ◽  
2010 ◽  
Vol 49 (8) ◽  
pp. 1798-1807 ◽  
Author(s):  
Hidekazu Katayama ◽  
Hironobu Hojo ◽  
Tsuyoshi Ohira ◽  
Akira Ishii ◽  
Takamichi Nozaki ◽  
...  
Keyword(s):  
Biological Activity ◽  
Androgenic Gland ◽  
Disulfide Pairing ◽  
Synthetic Studies

scholarly journals Modular synthesis of α-fluorinated arylmethanes via desulfonylative cross-coupling

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Masakazu Nambo ◽  
Jacky C.-H. Yim ◽  
Luiza B. O. Freitas ◽  
Yasuyo Tahara ◽  
Zachary T. Ariki ◽  
...  
Keyword(s):  
Biological Activity ◽  
Late Stage ◽  
Recent Progress ◽  
Cross Coupling ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Active Compounds ◽  
Arylboronic Acids ◽  
Modular Synthesis ◽  
Synthetic Routes

Abstract α-Fluoromethylarenes are common substructures in pharmaceuticals and agrochemicals, with the introduction of fluorine often resulting in improved biological activity and stability. Despite recent progress, synthetic routes to α-fluorinated diarylmethanes are still rare. Herein we describe the Pd-catalyzed Suzuki-Miyaura cross-coupling of α-fluorinated benzylic triflones with arylboronic acids affording structurally diverse α-fluorinated diarylmethanes. The ease of synthesis of fluorinated triflones as the key starting materials enables powerful late-stage transformations of known biologically active compounds into fluorinated analogs.

Biological Activity, Structural Features, and Synthetic Studies of (−)-Ternatin, a Potent Fat-Accumulation Inhibitor of 3T3-L1 Adipocytes

2008 ◽  
Vol 3 (2) ◽  
pp. 438-446 ◽  
Author(s):  
Kenichiro Shimokawa ◽  
Itsuka Mashima ◽  
Akiko Asai ◽  
Tomohiro Ohno ◽  
Kaoru Yamada ◽  
...  
Keyword(s):  
Biological Activity ◽  
Structural Features ◽  
Fat Accumulation ◽  
Synthetic Studies

ChemInform Abstract: Recent Progress of Synthetic Studies to Peptide and Peptidomimetic Cyclization

ChemInform ◽  
2009 ◽  
Vol 40 (32) ◽  
Author(s):  
Sheng Jiang ◽  
Zheng Li ◽  
Ke Ding ◽  
Peter P. Roller
Keyword(s):  
Recent Progress ◽  
Synthetic Studies

Amaryllidaceae and Sceletium alkaloids

2016 ◽  
Vol 33 (11) ◽  
pp. 1318-1343 ◽  
Author(s):  
Zhong Jin
Keyword(s):  
Biological Activity ◽  
Synthetic Studies

The latest progress on the isolation, identification, biological activity and synthetic studies of the structurally diverse alkaloids from plants of family Amaryllidaceae has been summarized in this review.

Synthetic Studies Towards Crinine-Type Amaryllidaceae Alkaloids: Synthesis of (±)-Oxocrinine and Formal Synthesis of (±)-Crinine

Synlett ◽  
2010 ◽  
Vol 2011 (02) ◽  
pp. 207-210 ◽  
Author(s):  
Xiaodong Yang ◽  
Lijuan Yang ◽  
Xuequan Wang ◽  
Zhiqiang Pan ◽  
Ming Zhou ◽  
...  
Keyword(s):  
Formal Synthesis ◽  
Amaryllidaceae Alkaloids ◽  
Synthetic Studies
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