Behavior of nanoceria in biologically-relevant environments

2014 ◽  
Vol 1 (6) ◽  
pp. 516-532 ◽  
Author(s):  
Amit Kumar ◽  
Soumen Das ◽  
Prabhakaran Munusamy ◽  
William Self ◽  
Donald R. Baer ◽  
...  
Keyword(s):  
Cerium Oxide ◽  
Cerium Oxide Nanoparticles ◽  
Biological Research ◽  
Oxide Nanoparticles ◽  
Biologically Relevant ◽  
Anti Oxidant

Cerium oxide nanoparticles (nanoceria) have gained considerable attention in biological research due to their anti-oxidant like behaviour and regenerative nature.

Size- and defect-controlled anti-oxidant enzyme mimetic and radical scavenging properties of cerium oxide nanoparticles

2018 ◽  
Vol 42 (23) ◽  
pp. 18810-18823 ◽  
Author(s):  
G. Vinothkumar ◽  
P. Arunkumar ◽  
Arun Mahesh ◽  
Arunkumar Dhayalan ◽  
K. Suresh Babu
Keyword(s):  
Enzymatic Activity ◽  
Cerium Oxide ◽  
Oxidase Activity ◽  
Radical Scavenging ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Selective Activation ◽  
Enzyme Mimetic ◽  
Anti Oxidant ◽  
Radical Scavenging Properties

Improved enzymatic activity and concentration-dependent selective activation of peroxidase and oxidase activity of combustion-synthesized nanoceria.

Cerium oxide nanoparticles and their importance in cell signaling pathways for predicting cellular behavior

Nanomedicine ◽  
2020 ◽  
Vol 15 (17) ◽  
pp. 1709-1718
Author(s):  
Atefeh Pesaraklou ◽  
Maryam M Matin
Keyword(s):  
Signaling Pathways ◽  
Cerium Oxide ◽  
Cellular Responses ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Signaling Proteins ◽  
Cellular Behavior ◽  
Anti Oxidant ◽  
Different Response ◽  
Cell Signaling Pathways

Cerium oxide nanoparticles (CeO2-NPs) have prolifically attracted immense interest of researchers due to their prominent anti-oxidant nature. However, these characteristics are accompanied by some ambiguities in other studies reporting their oxidant and toxic properties. In this regard previous literature has pointed to the importance of the NPs morphology and environmental conditions as well as biomolecules that induce a different response by initiating a cascade of activities. Therefore, due to the fact that signaling proteins are key mediators in cellular responses, the cognizance of the CeO2-NP-targeted signaling pathways could facilitate predicting the cellular behavior and thus more efficient applications of these NPs for clinical purposes. Consequently, a comprehensive review is necessary in this field, to clarify the impacts of CeO2-NPs on various signaling pathways.

scholarly journals The Anti-oxidant and Anti-inflammatory Properties of Cerium Oxide Nanoparticles Synthesized Using Origanum majorana L. Leaf Extract

2019 ◽  
Vol 4 (3) ◽  
pp. 108-112
Author(s):  
Ali Es-haghi ◽  
Saynaz Aseyd Nezhad
Keyword(s):  
Free Radicals ◽  
Cerium Oxide ◽  
Leaf Extract ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Gene Expressions ◽  
Frap Assay ◽  
Anti Oxidant ◽  
Anti Inflammatory ◽  
Origanum Majorana

Introduction: Free radicals have singlet electron in their outer layer rendering them high reactivity against biomolecules (i.e., DNA, carbohydrates, proteins, and lipids). Oxidative stress is created when the production of free radicals exceeds their removal by antioxidant systems and is involved in the pathogenesis of several diseases such as diabetes, arthritis, inflammatory conditions, and various cancers. Regarding the therapeutic potential of nanoparticles (NPs) in human diseases, the purpose of this study was to synthesize cerium oxide NPs using Origanum majorana leaf extract. Methods: Cerium oxide nanoparticles (CeO2 -NPs) were synthesized using aqueous leaf extract of O. majorana. The sizes of NPs were characterized by a particle size analyzer. The antioxidant properties of the CeO2 -NPs were determined by Ferric-reducing antioxidant power (FRAP) assay. The anti-inflammatory effects of the NPs were also determined by measuring gene expressions of IL-1β and IL-10 using real-time polymerase chain reaction (PCR). Results: The CeO2 -NPs were successfully synthesized using O. majorana leaf extract. The results of FRAP assay showed that the anti-oxidant activities of CeO2 -NPs at concentrations of 50, 100, and 400 μg/mL were 75%, 77.1%, and 94.5%, respectively. Moreover, interleukin 10 (IL-10) gene expressions increased by 4.6 folds while the expression of IL-1β gene decreased by 0.75-fold in HUVECs. Conclusion: The CeO2 -NPs synthesized using the aqueous extract of O. majorana demonstrated antioxidant and anti-inflammatory properties. Therefore, these NPs can be used as potential therapeutic agents in medicine.

Phosphate ester hydrolysis of biologically relevant molecules by cerium oxide nanoparticles

2010 ◽  
Vol 6 (6) ◽  
pp. 738-744 ◽  
Author(s):  
Melissa Hirsch Kuchma ◽  
Christopher B. Komanski ◽  
Jimmie Colon ◽  
Andrew Teblum ◽  
Artëm E. Masunov ◽  
...  
Keyword(s):  
Cerium Oxide ◽  
Ester Hydrolysis ◽  
Cerium Oxide Nanoparticles ◽  
Phosphate Ester ◽  
Oxide Nanoparticles ◽  
Biologically Relevant ◽  
Phosphate Ester Hydrolysis ◽  
Biologically Relevant Molecules ◽  
Hydrolysis Of

Polyacrylic Acid Modified Cerium Oxide Nanoparticles: Synthesis and Characterization as a Peroxidase Mimic for Non-Enzymatic H2O2 Sensor

2020 ◽  
Vol 16 (5) ◽  
pp. 816-828
Author(s):  
Gurdeep Rattu ◽  
Nishtha Khansili ◽  
Prayaga M. Krishna
Keyword(s):  
Hydrogen Peroxide ◽  
Cerium Oxide ◽  
Polyacrylic Acid ◽  
Spectroscopic Analysis ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Peroxidase Mimic ◽  
Ft Ir ◽  
H2o2 Sensing ◽  
Fluorescence Spectrometer

Background: Cerium oxide nanoparticles (nanoceria) are efficient free-radical scavengers due to their dual valence state and thus exhibit optical and catalytic properties. Therefore, the main purpose of this work was to understand the peroxidase mimic activity of polymer-stabilized nanoceria for enzyme-less H2O2 sensing by fluorescence spectrometer. Objective: This research revealed the development of fluorescence hydrogen peroxide nanosensor based on the peroxidase-like activity of polyacrylic acid stabilized nanoceria (PAA-CeO2 Nps). Methods: PAA-CeO2 Nps were synthesized by simple cross-linking reaction at a low temperature and characterized by XRD, SEM, Zeta potential, TGA, FT-IR and UV-VIS spectroscopic analysis. H2O2 sensing was performed by a fluorescence spectrometer. Results:: The synthesized polymer nanocomposite was characterized by XRD, SEM, TGA, FT-IR and UV-VIS spectroscopic analysis. The XRD diffraction patterns confirmed the polycrystalline nature and SEM micrograph showed nanoparticles having hexagonal symmetry and crystallite size of 32 nm. The broad peak of Ce–O bond appeared at 508 cm-1. UV-VIS measurements revealed a welldefined absorbance peak around 315 nm and an optical band-gap of 3.17 eV. As synthesized PAACeO2 Nps effectively catalysed the decomposition of hydrogen peroxide (H2O2) into hydroxyl radicals. Then terephthalic acid was oxidized by hydroxyl radical to form a highly fluorescent product. Under optimized conditions, the linear range for determination of hydrogen peroxide was 0.01 - 0.2 mM with a limit of detection (LOD) of 1.2 μM. Conclusion: The proposed method is ideally suited for the sensing of H2O2 at a low cost and this detection system enabled the sensing of analytes (sugars), which can enzymatically generate hydrogen peroxide.

Radiosensitizing Effect of Cerium Oxide Nanoparticles on Human Leukemia Cells

2018 ◽  
Vol 6 (2) ◽  
pp. 111-115 ◽  
Author(s):  
Azadeh Montazeri ◽  
Zohreh Zal ◽  
Arash Ghasemi ◽  
Hooman Yazdannejat ◽  
Hossein Asgarian-Omran ◽  
...  
Keyword(s):  
Cerium Oxide ◽  
Leukemia Cells ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Human Leukemia ◽  
Radiosensitizing Effect ◽  
Human Leukemia Cells

Cerium oxide nanoparticles acts as a novel therapeutic agent for ulcerative colitis through anti-oxidative mechanism

Life Sciences ◽  
2021 ◽  
pp. 119500
Author(s):  
Fereshteh Asgharzadeh ◽  
Alireza Hashemzadeh ◽  
Farzad Rahmani ◽  
Atieh Yaghoubi ◽  
Seyedeh Elnaz Nazari ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Cerium Oxide ◽  
Therapeutic Agent ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Novel Therapeutic
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