Dual-functional cyclic peptide switch on mesoporous nanocontainers for selective CD44 targeting and on–off gatekeeping triggered by conformational transformation

2018 ◽  
Vol 42 (15) ◽  
pp. 12938-12944 ◽  
Author(s):  
Jeonghun Lee ◽  
Eun-Taex Oh ◽  
Min Hyeuk Choi ◽  
Ha Gyeong Kim ◽  
Heon Joo Park ◽  
...  
Keyword(s):  
Drug Release ◽  
Cyclic Peptide ◽  
Conformational Transformation ◽  
Dual Functional ◽  
Selective Targeting ◽  
Triggered Drug Release ◽  
Cd44 Targeting

A dual functional cyclic peptide gatekeeper with A6 sequence is designed not only for triggered drug release by conformational transformation of the peptide but also selective targeting of CD44.

Specific HER2 targeting and triggered drug release by conformational transformation of a dual-functional peptide gatekeeper on mesoporous nanocontainers

2019 ◽  
Vol 43 (29) ◽  
pp. 11497-11502 ◽  
Author(s):  
Jeonghun Lee ◽  
Eun-Taex Oh ◽  
Hansol Kang ◽  
Jiwon Kim ◽  
Ha Gyeong Kim ◽  
...  
Keyword(s):  
Drug Release ◽  
Cyclic Peptide ◽  
Conformational Transformation ◽  
Stimuli Responsive ◽  
Specific Targeting ◽  
Dual Functional ◽  
Triggered Drug Release ◽  
Functional Peptide ◽  
Binding Sequence

For specific targeting of HER2 and triggered drug release by stimuli-responsive conformational transformation, we developed a dual-functional cyclic peptide gatekeeper containing a HER2-binding sequence on the surface of mesoporous nanocontainers.

Facile synthesis of organosilica-capped mesoporous silica nanocarriers with selective redox-triggered drug release properties for safe tumor chemotherapy

2019 ◽  
Vol 7 (5) ◽  
pp. 1825-1832 ◽  
Author(s):  
Luying Shen ◽  
Shan Pan ◽  
Dechao Niu ◽  
Jianping He ◽  
Xiaobo Jia ◽  
...  
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Facile Synthesis ◽  
Triggered Drug Release ◽  
Facile Route

We develop a facile route to synthesize organosilica-capped mesoporous silica nanocarriers for efficient and safe redox-triggered tumor chemotherapy.

scholarly journals pH-triggered degradation and release of doxorubicin from zeolitic imidazolate framework-8 (ZIF8) decorated with polyacrylic acid

RSC Advances ◽  
2021 ◽  
Vol 11 (16) ◽  
pp. 9222-9234
Author(s):  
Vy Anh Tran ◽  
Sang-Wha Lee
Keyword(s):  
Drug Release ◽  
Polyacrylic Acid ◽  
Acidic Ph ◽  
Zeolitic Imidazolate Framework ◽  
Triggered Drug Release

The ZIF8–Dox@PAA nanocarrier demonstrated pH-triggered drug release through the detachment of the PAA layer along with the destruction of ZIF8 framework in acidic pH environment.

PEG–PEI-modified gated N-doped mesoporous carbon nanospheres for pH/NIR light-triggered drug release and cancer phototherapy

2021 ◽  
Author(s):  
Snigdharani Panda ◽  
Chandra Sekhar Bhol ◽  
Sujit Kumar Bhutia ◽  
Sasmita Mohapatra
Keyword(s):  
Drug Release ◽  
Mesoporous Carbon ◽  
Laser Excitation ◽  
Outer Shell ◽  
Carbon Nanospheres ◽  
Nir Light ◽  
Triggered Drug Release ◽  
Hybrid Nanoparticle

A hybrid nanoparticle consisting of N-doped mesoporous carbon nanospheres as core and thermosensitive PEG–PEI as outer shell shows multiple therapeutic actions such as PTT, PDT and NIR sensitive drug release under single 980 nm laser excitation.

Imaging Laser-Triggered Drug Release from Gold Nanocages with Transient Absorption Lifetime Microscopy

2017 ◽  
Vol 9 (23) ◽  
pp. 19653-19661 ◽  
Author(s):  
Yongkui Xu ◽  
Qi Liu ◽  
Ruoyu He ◽  
Xianchong Miao ◽  
Minbiao Ji
Keyword(s):  
Drug Release ◽  
Transient Absorption ◽  
Gold Nanocages ◽  
Triggered Drug Release

Redox-responsive degradable honeycomb manganese oxide nanostructures as effective nanocarriers for intracellular glutathione-triggered drug release

2015 ◽  
Vol 51 (4) ◽  
pp. 776-779 ◽  
Author(s):  
Dinggeng He ◽  
Xiaoxiao He ◽  
Kemin Wang ◽  
Xue Yang ◽  
Xiaoxiao Yang ◽  
...  
Keyword(s):  
Drug Release ◽  
Manganese Oxide ◽  
Drug Carriers ◽  
New Class ◽  
Oxide Nanostructures ◽  
Redox Responsive ◽  
Intracellular Glutathione ◽  
Triggered Drug Release

Redox-responsive degradable honeycomb manganese oxide (hMnO2) nanostructures consisting of some lamellar MnO2 platelets were established as a new class of drug carriers for efficient intracellular GSH-triggered drug release.

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