Mesoporous Silica Nanocarriers with Cyclic Peptide Gatekeeper: Specific Targeting of Aminopeptidase N and Triggered Drug Release by Stimuli-Responsive Conformational Transformation

2017 ◽  
Vol 23 (67) ◽  
pp. 16966-16971 ◽  
Author(s):  
Jeonghun Lee ◽  
Eun-Taex Oh ◽  
Yeji Han ◽  
Ha Gyeong Kim ◽  
Heon Joo Park ◽  
...  
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Cyclic Peptide ◽  
Aminopeptidase N ◽  
Conformational Transformation ◽  
Stimuli Responsive ◽  
Specific Targeting ◽  
Triggered Drug Release

Specific HER2 targeting and triggered drug release by conformational transformation of a dual-functional peptide gatekeeper on mesoporous nanocontainers

2019 ◽  
Vol 43 (29) ◽  
pp. 11497-11502 ◽  
Author(s):  
Jeonghun Lee ◽  
Eun-Taex Oh ◽  
Hansol Kang ◽  
Jiwon Kim ◽  
Ha Gyeong Kim ◽  
...  
Keyword(s):  
Drug Release ◽  
Cyclic Peptide ◽  
Conformational Transformation ◽  
Stimuli Responsive ◽  
Specific Targeting ◽  
Dual Functional ◽  
Triggered Drug Release ◽  
Functional Peptide ◽  
Binding Sequence

For specific targeting of HER2 and triggered drug release by stimuli-responsive conformational transformation, we developed a dual-functional cyclic peptide gatekeeper containing a HER2-binding sequence on the surface of mesoporous nanocontainers.

Dual-functional cyclic peptide switch on mesoporous nanocontainers for selective CD44 targeting and on–off gatekeeping triggered by conformational transformation

2018 ◽  
Vol 42 (15) ◽  
pp. 12938-12944 ◽  
Author(s):  
Jeonghun Lee ◽  
Eun-Taex Oh ◽  
Min Hyeuk Choi ◽  
Ha Gyeong Kim ◽  
Heon Joo Park ◽  
...  
Keyword(s):  
Drug Release ◽  
Cyclic Peptide ◽  
Conformational Transformation ◽  
Dual Functional ◽  
Selective Targeting ◽  
Triggered Drug Release ◽  
Cd44 Targeting

A dual functional cyclic peptide gatekeeper with A6 sequence is designed not only for triggered drug release by conformational transformation of the peptide but also selective targeting of CD44.

Facile synthesis of organosilica-capped mesoporous silica nanocarriers with selective redox-triggered drug release properties for safe tumor chemotherapy

2019 ◽  
Vol 7 (5) ◽  
pp. 1825-1832 ◽  
Author(s):  
Luying Shen ◽  
Shan Pan ◽  
Dechao Niu ◽  
Jianping He ◽  
Xiaobo Jia ◽  
...  
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Facile Synthesis ◽  
Triggered Drug Release ◽  
Facile Route

We develop a facile route to synthesize organosilica-capped mesoporous silica nanocarriers for efficient and safe redox-triggered tumor chemotherapy.

Mesoporous silica nanobeans dual-functionalized with AIEgens and leaning pillar[6]arene-based supramolecular switches for imaging and stimuli-responsive drug release

2019 ◽  
Vol 55 (94) ◽  
pp. 14099-14102 ◽  
Author(s):  
Xiangshuai Li ◽  
Junyou Han ◽  
Jianchun Qin ◽  
Ming Sun ◽  
Jiarui Wu ◽  
...  
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Stimuli Responsive ◽  
Tumor Inhibition ◽  
Turn On ◽  
Functionalized Mesoporous Silica

Dual-functionalized mesoporous silica nanobeans capable of GSH-dependent turn-on fluorescence and stimuli-responsive drug release are prepared for tumor inhibition and imaging.

scholarly journals Bioresponsive Mesoporous Silica Nanoparticles for Triggered Drug Release

2011 ◽  
Vol 133 (49) ◽  
pp. 19582-19585 ◽  
Author(s):  
Neetu Singh ◽  
Amrita Karambelkar ◽  
Luo Gu ◽  
Kevin Lin ◽  
Jordan S. Miller ◽  
...  
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Triggered Drug Release

Light-Triggered Drug Release Platform Based on Superhydrophobicity of Mesoporous Silica Nanoparticles

2016 ◽  
Vol 8 (5) ◽  
pp. 428-433 ◽  
Author(s):  
Wanyuan Gui ◽  
Junpin Lin ◽  
Guojian Hao ◽  
Yongfeng Liang ◽  
Wenqian Wang ◽  
...  
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Triggered Drug Release

Combinatory Cancer Therapeutics with Nanoceria-Capped Mesoporous Silica Nanocarriers through pH-triggered Drug Release and Redox Activity

2018 ◽  
Vol 11 (1) ◽  
pp. 288-299 ◽  
Author(s):  
Rajendra K. Singh ◽  
Kapil D. Patel ◽  
Chinmaya Mahapatra ◽  
S. Prakash Parthiban ◽  
Tae-Hyun Kim ◽  
...  
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Cancer Therapeutics ◽  
Redox Activity ◽  
Triggered Drug Release
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