Novel membranes from physico-chemically modified deproteinized natural rubber latex: development, characterisation and drug permeation

2018 ◽  
Vol 42 (17) ◽  
pp. 14179-14187
Author(s):  
Janisha Jayadevan ◽  
G. Unnikrishnan
Keyword(s):  
Drug Release ◽  
Natural Rubber ◽  
Natural Rubber Latex ◽  
Rubber Latex ◽  
Drug Permeation ◽  
Chemically Modified ◽  
Blend Membranes ◽  
Deproteinized Natural Rubber

Novel blend membranes from physico-chemically modified deproteinized natural rubber latex for drug release applications.

Silver nanoparticles effect on drug release of metronidazole in natural rubber latex dressing

2021 ◽  
Author(s):  
Matheus Carlos Romeiro Miranda ◽  
Nicola Carlucci Sato ◽  
Giovana Sant’Ana Pegorin Brasil ◽  
Rodolfo Debone Piazza ◽  
Miguel Jafelicci ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Drug Release ◽  
Natural Rubber ◽  
Natural Rubber Latex ◽  
Rubber Latex

Characterization of Lidocaine Transdermal Patches from Natural Rubber Latex

2013 ◽  
Vol 747 ◽  
pp. 103-106 ◽  
Author(s):  
Prapaporn Boonme ◽  
Hasleena Boontawee ◽  
Wirach Taweepreda ◽  
Wiwat Pichayakorn
Keyword(s):  
Drug Release ◽  
Natural Rubber ◽  
Physicochemical Properties ◽  
Rubber Tree ◽  
Natural Rubber Latex ◽  
Rubber Latex ◽  
Transdermal Patches ◽  
The Stability ◽  
Main Component

The mucous liquid of Hevea brasiliensis or Para rubber tree, called natural rubber latex (NRL), composes of cis-1,4-polyisoprene which can form a patch under suitable formulation. In this study, blank and 5% lidocaine-loaded NRL patches were formulated and then characterized for physicochemical properties as well as evaluated in vitro drug release and stability. The patches were observed for their appearances. Surface morphology of the patches was investigated using a SEM. XRD was employed to study the crystallinity of the drug, the patch, and the drug-loaded patch. The extractions of lidocaine-loaded patches were analyzed for drug contents by HPLC. In vitro drug release study was performed using modified Franz diffusion cells. The patches at initial preparation and after kept at 4, 25, and 45 °C for 3 months were investigated for the stability determination. The results suggested that NRL could be used as a main component in pharmaceutical transdermal patches with acceptable physicochemical properties. Lidocaine-loaded NRL patches provided desirable drug release but high storage temperatures could age the patches resulting in darken color and lower release amount.

Development of latex foam pillows from deproteinized natural rubber latex

2021 ◽  
Author(s):  
Roslim Ramli ◽  
Ai Bao Chai ◽  
Shamsul Kamaruddin ◽  
Jee Hou Ho ◽  
Fatimah Rubaizah Mohd. Rasdi ◽  
...  
Keyword(s):  
Natural Rubber ◽  
Natural Rubber Latex ◽  
Rubber Latex ◽  
Deproteinized Natural Rubber

Deproteinized Natural Rubber as Chewing Gum Base for Nicotine Delivery

2013 ◽  
Vol 844 ◽  
pp. 470-473
Author(s):  
Wiwat Pichayakorn ◽  
Prapaporn Boonme ◽  
Wirach Taweepreda
Keyword(s):  
Natural Rubber ◽  
Room Temperature ◽  
Natural Rubber Latex ◽  
Sodium Carboxymethylcellulose ◽  
Rubber Latex ◽  
Initial Modulus ◽  
Chewing Gums ◽  
Significant Difference ◽  
Saccharin Sodium ◽  
Deproteinized Natural Rubber

This study aimed to prepare the nicotine chewing gums for smoking cessation using deproteinized natural rubber latex (DNRL) as gum bases due to its highly flexible property. The formulations were produced by the conventional heat melting and kneading methods. The experimental design was used to obtain the optimum 3 gum base formulations. Each formulation composed of olive oil as a plasticizer; sodium carboxymethylcellulose as an adsorbent; xylitol, mannitol and saccharin sodium as sweeteners instead of sugar. Gum base 1 and gum base 2 had the same sweetener amount but gum base 2 had the lower plasticizer amount, while gum base 1 and gum base 3 had the same plasticizer amount but different sweetener amount. Nicotine was added into each 3 gum bases (NCT1-3). The results showed no significant difference of appearance and taste. Their physicochemical properties were as following: pH of 8.45, 8.46, 8.54, hardness of 39.80, 36.28, 33.14 Shore A, initial modulus of 0.090, 1.260, 0.065 MPa, %elongation of 286, 403, 489%, drug content of 63.62, 70.95, 72.70%, and drug release when 500 times for force clamping of 48.72, 45.72, 67.74%, respectively. After storage at room temperature for 1 month, NCT1 and NCT2 showed unchangeable appearance, but NCT3 showed the slightly liquefied film and much sticky due to hygroscopic property of its sweetener. However, all formulations showed the significant reduction of drug amount which should be further improved in their stability properties.

Propranolol Hydrochloride Extended-Release Matrix Tablets Using Natural Rubber Latex as Binder

2013 ◽  
Vol 747 ◽  
pp. 91-94 ◽  
Author(s):  
Kamon Panrat ◽  
Prapaporn Boonme ◽  
Wirach Taweepreda ◽  
Wiwat Pichayakorn
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Natural Rubber ◽  
Release Rate ◽  
Drug Delivery Systems ◽  
Natural Rubber Latex ◽  
Delivery Systems ◽  
Matrix Tablets ◽  
Propranolol Hydrochloride ◽  
Rubber Latex

Matrix is one of the most interesting drug delivery systems to control drug release in pharmaceutical dosage forms. Natural rubber latex (NRL) from Hevea brasiliensis consists of cis-1,4-polyisoprene as the major polymer. It presents interesting physical properties such as easy to manipulate, low cost, high mechanical resistance, and insoluble in water. The aim of this study was to use the NRL as binder in matrix tablets for controlling the release rate of drug. NRL, sodium carboxymethylcellulose, olive oil, Tween 80, and lactose were used as polymer, adsorbent, plasticizer, surfactant, and diluent, respectively. Propranolol hydrochloride was used as a model drug. Propranolol hydrochloride matrix tablets were prepared by conventional heat-melting method. The in vitro release of drug from matrix tablets was determined by UV-Vis method according to dissolution test under Propranolol Hydrochloride Tablets USP30-NF25 monograph. Morphology of propranolol hydrochloride matrix tablet before and after released study was observed by scanning electron microscopy (SEM). It was found that NRL matrix tablets could control the drug release up to 12 hours. The release profiles were best fitted with Higuchi model. NRL amounts affected the properties of the propranolol hydrochloride matrix tablets. Increasing the NRL quantity in the matrices provided the decrease of release rate of drug. SEM photographs showed the number, size, and distribution of pore in propranolol hydrochloride matrix tablets that depended on amount of NRL addition. These results confirmed that NRL was possible to use as binder for matrix tablets in oral drug delivery systems.

Effect of Modified Natural Rubber on Morphology, Chemical Structure, and Crystallinity of Electrospun Polyvinylidene Difluoride Nanofibers

2019 ◽  
Vol 950 ◽  
pp. 128-132
Author(s):  
Jean Raynell S. Bello ◽  
Bryan B. Pajarito ◽  
Jem Valerie D. Perez
Keyword(s):  
Natural Rubber ◽  
Chemical Structure ◽  
Fiber Diameter ◽  
Natural Rubber Latex ◽  
X Ray Diffraction ◽  
Rubber Latex ◽  
Polyvinylidene Difluoride ◽  
X Ray ◽  
Chemically Modified ◽  
Enzymatic Deproteinization

Natural rubber latex was chemically modified by enzymatic deproteinization, degradation, and epoxidation to produce deproteinized liquid epoxidized natural rubber (DP-LENR). Polyvinylidene difluoride (PVDF) was blended with DP-LENR and then electrospun to produce nanofibers. Scanning electron microscopy shows reduction in the fiber diameter and beading formation with increasing concentration of DP-LENR. Smooth surface of nanofibers suggests miscibility and chemical compatibility of PVDF with low concentration of DP-LENR. Infrared spectroscopy and X-ray diffraction analysis show the addition of DP-LENR has no effect on chemical structure and crystallinity of electrospun PVDF.

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