Organotin compound DBDCT induces CYP3A suppression through NF-κB-mediated repression of PXR activity

Metallomics ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 936-948 ◽  
Author(s):  
Yunlan Li ◽  
Niu Lin ◽  
Xiaoqing Ji ◽  
Jiaqi Mai ◽  
Qingshan Li
Keyword(s):  
Anticancer Agent ◽  
Organotin Compound ◽  
Inhibitory Effect ◽  
Metabolic Enzyme

Organotin anticancer agent di-n-butyl-di-(4-chlorobenzohydroxamato)tin(iv) (DBDCT) exerted an inhibitory effect on its major metabolic enzyme cytochrome CYP3A.

A proposed mechanism for the inhibitory effect of the anticancer agent titanocene dichloride on tumour gelatinases and other proteolytic enzymes

2009 ◽  
Vol 14 (6) ◽  
pp. 947-957 ◽  
Author(s):  
Maria Pavlaki ◽  
Katerina Debeli ◽  
Irene-Eva Triantaphyllidou ◽  
Nikolaos Klouras ◽  
Eleftheria Giannopoulou ◽  
...  
Keyword(s):  
Anticancer Agent ◽  
Proteolytic Enzymes ◽  
Inhibitory Effect ◽  
Titanocene Dichloride

scholarly journals Cytotoxic, Antioxidant, and Metabolic Enzyme Inhibitory Activities of Euphorbia cyparissias Extracts

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Mona Alonazi ◽  
Habib Horchani ◽  
Mona Alwhibi ◽  
Abir Ben Bacha
Keyword(s):  
Metabolic Syndrome ◽  
Digestive Enzymes ◽  
Reducing Power ◽  
Ethanolic Extract ◽  
Inhibitory Effect ◽  
Positive Control ◽  
Metabolic Enzyme ◽  
Wide Range ◽  
Potential Applications ◽  
Euphorbia Cyparissias

Plants of the Euphorbia genus present a wide range of therapeutic applications. This study is aimed at investigating new antidigestive enzyme agents from Euphorbia cyparissias through inhibition of lipid and carbohydrate absorption, to evaluate their potential applications for the treatment of metabolic syndrome. Lipase, phospholipase, protease, α-amylase, β-glucosidase, and xanthine oxidase activities under treatment with aqueous and ethanolic extracts of Euphorbia cyparissias were observed to evaluate the inhibitory effect of these extracts, as well as their antioxidant and cytotoxic effects. Results showed that ethanolic and aqueous extracts exhibited important inhibitory activity in a concentration-related manner on digestive enzymes, which is more effective than the commercial drugs used as controls. Results also showed that, out of the two extracts tested, the ethanolic extract presented the most promising results in inhibiting the activities of all digestive enzymes used. Moreover, the two extracts displayed a higher reducing power than that of the positive control used. The obtained results, together with previous reports in the literature, strongly suggest that Euphorbia cyparissias extracts may be natural inhibitors of the digestive enzymes and thus a potential new drug for metabolic syndrome treatment.

scholarly journals Different 4T1 Cells Migration under Caesalpinia sappan L. and Ficus septica Burm.f Ethanolic Extracts

2017 ◽  
Vol 8 (1) ◽  
pp. 21 ◽  
Author(s):  
Sari Haryanti ◽  
Retno Murwanti ◽  
Herwandhani Putri ◽  
Gagas Pradani Nur Ilmawati ◽  
Suwijiyo Pramono ◽  
...  
Keyword(s):  
Anticancer Agent ◽  
Gelatin Zymography ◽  
Ethanolic Extract ◽  
Cell Types ◽  
Inhibitory Effect ◽  
Caesalpinia Sappan ◽  
Ic50 Value ◽  
Anti Cancer ◽  
Ethanolic Extracts ◽  
4T1 Cells

Secang (C. sappan L.) and awar (F. septica Burm.f) are known of Indonesian traditional medicine that highly consumed throughout centuries in order to cure various diseases. Recently, researchers also concern about its effects as anti-cancer on various cell types. This study was conducted to understand the ethanolic extract of C. sappan L. (ECS) and F. septica Burm.f (EFS) effects on 4T1 cells migration at various concentrations. Firstly, we examine cell proliferation profile with MTT assay under treatment with the extracts and obtained the IC50 value of ECS (20 μg/mL) and EFS (15 μg/mL). Subsequent assay conducted was to examine the cells migration under low concentration resulting in the migration inhibitory effect of both EFS and ECS with different intensity.  EFS performed better migration inhibitory effect than ECS. Finally, we conducted gelatin zymography and western blot and revealed that the migration inhibitory effect of EFS may correlate to the lowering of protein expression of MMP9 and Rac-1 after 24 hours of treatment. We conclude that both extracts are potential to be developed as anticancer agent and EFS is more potent for anti-metastasis.Keywords: C. sappan L., F. septica Burm.f, 4T1, anti-migration

Inhibitory effect of melatonin on nitric oxide synthase in rat enteric nervous system

2001 ◽  
Vol 120 (5) ◽  
pp. A176-A176
Author(s):  
P KOPPITZ ◽  
M STORR ◽  
D SAUR ◽  
M KURJAK ◽  
H ALLESCHER
Keyword(s):  
Nitric Oxide ◽  
Nervous System ◽  
Nitric Oxide Synthase ◽  
Enteric Nervous System ◽  
Inhibitory Effect ◽  
Oxide Synthase

Inhibitory effect of proton pump inhibitors against chemotaxis of Helicobacter pylori

2001 ◽  
Vol 120 (5) ◽  
pp. A655-A656
Author(s):  
H NAKAMURA ◽  
H YOSHIYAMA ◽  
H YANAI ◽  
M SHIRAL ◽  
T NAKAZAWA ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Inhibitory Effect

The Nature of the Inhibitory Effect of Normal Human Gastric Jiuice on Heidenhain Pouch Dogs

1958 ◽  
Vol 34 (2) ◽  
pp. 181-187 ◽  
Author(s):  
William O. Smith ◽  
Robert Hoke ◽  
Jerome Landy ◽  
Ranwel Caputto ◽  
Stewart Wolf
Keyword(s):  
Inhibitory Effect ◽  
Heidenhain Pouch ◽  
Normal Human

Inhibitory effect of Rhamnus alpinus and Rhamnus saxatilis extracts on chemokine secretion induced by lipopolysaccharide in monocyte-derived macrophages

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
F Epifano ◽  
L Menghini ◽  
A Chiavaroli ◽  
G Orlando ◽  
VD La ◽  
...  
Keyword(s):  
Inhibitory Effect
Sign in / Sign up

Export Citation Format

Share Document