Identifying glioblastoma margins using dual-targeted organic nanoparticles for efficient in vivo fluorescence image-guided photothermal therapy

2019 ◽  
Vol 6 (2) ◽  
pp. 311-317 ◽  
Author(s):  
Xiaolei Cai ◽  
Aishwarya Bandla ◽  
Chan Kim Chuan ◽  
Gayathiri Magarajah ◽  
Lun-De Liao ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Tumour Growth ◽  
Fluorescence Image ◽  
Organic Nanoparticles ◽  
Image Guided ◽  
In Vivo Fluorescence

Dual-targeted organic nanoparticles efficiently target the margin of glioblastoma and successfully suppress the tumour growth through photothermal therapy.

scholarly journals Upconversion NIR-II fluorophores for mitochondria-targeted cancer imaging and photothermal therapy

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Hui Zhou ◽  
Xiaodong Zeng ◽  
Anguo Li ◽  
Wenyi Zhou ◽  
Lin Tang ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Biomedical Applications ◽  
Cell Imaging ◽  
Upconversion Luminescence ◽  
Great Promise ◽  
Osteosarcoma Cells ◽  
Image Guided ◽  
Donor Acceptor ◽  
Subcellular Resolution

AbstractNIR-II fluorophores have shown great promise for biomedical applications with superior in vivo optical properties. To date, few small-molecule NIR-II fluorophores have been discovered with donor-acceptor-donor (D-A-D) or symmetrical structures, and upconversion-mitochondria-targeted NIR-II dyes have not been reported. Herein, we report development of D-A type thiopyrylium-based NIR-II fluorophores with frequency upconversion luminescence (FUCL) at ~580 nm upon excitation at ~850 nm. H4-PEG-PT can not only quickly and effectively image mitochondria in live or fixed osteosarcoma cells with subcellular resolution at 1 nM, but also efficiently convert optical energy into heat, achieving mitochondria-targeted photothermal cancer therapy without ROS effects. H4-PEG-PT has been further evaluated in vivo and exhibited strong tumor uptake, specific NIR-II signals with high spatial and temporal resolution, and remarkable NIR-II image-guided photothermal therapy. This report presents the first D-A type thiopyrylium NIR-II theranostics for synchronous upconversion-mitochondria-targeted cell imaging, in vivo NIR-II osteosarcoma imaging and excellent photothermal efficiency.

ONOO– and ClO– Responsive Organic Nanoparticles for Specific in Vivo Image-Guided Photodynamic Bacterial Ablation

2018 ◽  
Vol 30 (11) ◽  
pp. 3867-3873 ◽  
Author(s):  
Wenbo Wu ◽  
Duo Mao ◽  
Xiaolei Cai ◽  
Yukun Duan ◽  
Fang Hu ◽  
...  
Keyword(s):  
Organic Nanoparticles ◽  
Image Guided

Correction: In Vitro and In Vivo Near-Infrared Photothermal Therapy of Cancer Using Polypyrrole Organic Nanoparticles

2013 ◽  
Vol 25 (7) ◽  
pp. 945-945 ◽  
Author(s):  
Kai Yang ◽  
Huan Xu ◽  
Liang Cheng ◽  
Chunyang Sun ◽  
Jun Wang ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Near Infrared ◽  
Organic Nanoparticles

Ultrasound and photoacoustic image-guided photothermal therapy using silica-coated gold nanorods: In-vivo study

2010 ◽  
Author(s):  
Seungsoo Kim ◽  
Yun-Sheng Chen ◽  
Geoffrey P. Luke ◽  
Mohammad Mehrmohammadi ◽  
Jason R. Cook ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
Photothermal Therapy ◽  
In Vivo Study ◽  
Image Guided

scholarly journals Indocyanine Green-Based Theranostic Nanoplatform for NIR Fluorescence Image-Guided Chemo/Photothermal Therapy of Cervical Cancer

2021 ◽  
Vol Volume 16 ◽  
pp. 4847-4861
Author(s):  
Rong Ma ◽  
Nuernisha Alifu ◽  
Zhong Du ◽  
Shuang Chen ◽  
Youqiang Heng ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Indocyanine Green ◽  
Photothermal Therapy ◽  
Fluorescence Image ◽  
Image Guided ◽  
Nir Fluorescence

scholarly journals Laparoscopic fluorescence image-guided photothermal therapy enhances cancer diagnosis and treatment

2019 ◽  
Vol 3 (1) ◽  
pp. 89-102 ◽  
Author(s):  
Mohan Singh ◽  
Elham Nabavi ◽  
Yu Zhou ◽  
Maria Elena Gallina ◽  
Hailin Zhao ◽  
...  
Keyword(s):  
Cancer Diagnosis ◽  
Photothermal Therapy ◽  
Diagnosis And Treatment ◽  
Fluorescence Image ◽  
Image Guided

Robust Red Organic Nanoparticles for In Vivo Fluorescence Imaging of Cancer Cell Progression in Xenografted Zebrafish

2017 ◽  
Vol 27 (31) ◽  
pp. 1701418 ◽  
Author(s):  
Gengwei Lin ◽  
Purnima Naresh Manghnani ◽  
Duo Mao ◽  
Cathleen Teh ◽  
Yinghao Li ◽  
...  
Keyword(s):  
Fluorescence Imaging ◽  
Cancer Cell ◽  
Organic Nanoparticles ◽  
In Vivo Fluorescence ◽  
Cell Progression ◽  
In Vivo Fluorescence Imaging

An implantable light source for in-vivo fluorescence image sensor

2020 ◽  
Author(s):  
Kiyotaka Sasagawa ◽  
Erus Rustami ◽  
Hironari Takehara ◽  
Makito Haruta ◽  
Jun Ohta
Keyword(s):  
Light Source ◽  
Image Sensor ◽  
Fluorescence Image ◽  
In Vivo Fluorescence

In Vitro and In Vivo Near-Infrared Photothermal Therapy of Cancer Using Polypyrrole Organic Nanoparticles

2012 ◽  
Vol 24 (41) ◽  
pp. 5586-5592 ◽  
Author(s):  
Kai Yang ◽  
Huan Xu ◽  
Liang Cheng ◽  
Chunyang Sun ◽  
Jun Wang ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Near Infrared ◽  
Organic Nanoparticles
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