ONOO– and ClO– Responsive Organic Nanoparticles for Specific in Vivo Image-Guided Photodynamic Bacterial Ablation

2018 ◽  
Vol 30 (11) ◽  
pp. 3867-3873 ◽  
Author(s):  
Wenbo Wu ◽  
Duo Mao ◽  
Xiaolei Cai ◽  
Yukun Duan ◽  
Fang Hu ◽  
...  
Keyword(s):  
Organic Nanoparticles ◽  
Image Guided

Identifying glioblastoma margins using dual-targeted organic nanoparticles for efficient in vivo fluorescence image-guided photothermal therapy

2019 ◽  
Vol 6 (2) ◽  
pp. 311-317 ◽  
Author(s):  
Xiaolei Cai ◽  
Aishwarya Bandla ◽  
Chan Kim Chuan ◽  
Gayathiri Magarajah ◽  
Lun-De Liao ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Tumour Growth ◽  
Fluorescence Image ◽  
Organic Nanoparticles ◽  
Image Guided ◽  
In Vivo Fluorescence

Dual-targeted organic nanoparticles efficiently target the margin of glioblastoma and successfully suppress the tumour growth through photothermal therapy.

scholarly journals Organic Nanocarriers for Bevacizumab Delivery: An Overview of Development, Characterization and Applications

Molecules ◽  
2021 ◽  
Vol 26 (14) ◽  
pp. 4127
Author(s):  
Aline de Cristo Soares Alves ◽  
Franciele Aline Bruinsmann ◽  
Silvia Stanisçuaski Guterres ◽  
Adriana Raffin Pohlmann
Keyword(s):  
Monoclonal Antibody ◽  
Physicochemical Characterization ◽  
Vascular Endothelial ◽  
Organic Nanoparticles ◽  
Humanized Monoclonal Antibody ◽  
Angiogenesis Process ◽  
Endothelial Growth Factor ◽  
Drug Pharmacokinetics

Bevacizumab (BCZ) is a recombinant humanized monoclonal antibody against the vascular endothelial growth factor, which is involved in the angiogenesis process. Pathologic angiogenesis is observed in several diseases including ophthalmic disorders and cancer. The multiple administrations of BCZ can cause adverse effects. In this way, the development of controlled release systems for BCZ delivery can promote the modification of drug pharmacokinetics and, consequently, decrease the dose, toxicity, and cost due to improved efficacy. This review highlights BCZ formulated in organic nanoparticles providing an overview of the physicochemical characterization and in vitro and in vivo biological evaluations. Moreover, the main advantages and limitations of the different approaches are discussed. Despite difficulties in working with antibodies, those nanocarriers provided advantages in BCZ protection against degradation guaranteeing bioactivity maintenance.

Integration between in vivo dosimetry and image guided radiotherapy for lung tumors

2009 ◽  
Vol 36 (6Part1) ◽  
pp. 2206-2214 ◽  
Author(s):  
Angelo Piermattei ◽  
Savino Cilla ◽  
Luca Grimaldi ◽  
Domenico Sabatino ◽  
Andrea Fidanzio ◽  
...  
Keyword(s):  
Lung Tumors ◽  
In Vivo Dosimetry ◽  
Image Guided Radiotherapy ◽  
Image Guided

Image-guided in vivo dosimetry for quality assurance of IMRT treatment for prostate cancer

2007 ◽  
Vol 67 (1) ◽  
pp. 288-295 ◽  
Author(s):  
Hansjoerg Wertz ◽  
Judit Boda-Heggemann ◽  
Cornelia Walter ◽  
Barbara Dobler ◽  
Sabine Mai ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Quality Assurance ◽  
In Vivo Dosimetry ◽  
Image Guided

In-vivo ultrasound and photoacoustic image- guided photothermal cancer therapy using silica-coated gold nanorods

2014 ◽  
Vol 61 (5) ◽  
pp. 891-897 ◽  
Author(s):  
Seungsoo Kim ◽  
Yun-sheng Chen ◽  
Geoffrey P. Luke ◽  
Stanislav Y. Emelianov
Keyword(s):  
Cancer Therapy ◽  
Gold Nanorods ◽  
Image Guided

scholarly journals Image-guided chemistry altering biology: An in vivo study of thermoembolization

PLoS ONE ◽  
2018 ◽  
Vol 13 (7) ◽  
pp. e0200471 ◽  
Author(s):  
Erik N. K. Cressman ◽  
Chunxiao Guo ◽  
Niloofar Karbasian
Keyword(s):  
In Vivo Study ◽  
Image Guided

scholarly journals An interventional image‐guided microdevice implantation and retrieval method for in‐vivo drug response assessment

2019 ◽  
Vol 46 (11) ◽  
pp. 5134-5143 ◽  
Author(s):  
Sharath K. Bhagavatula ◽  
Kunj Upadhyaya ◽  
Brendyn J. Miller ◽  
Patrick Bursch ◽  
Alex Lammers ◽  
...  
Keyword(s):  
Drug Response ◽  
Response Assessment ◽  
Retrieval Method ◽  
Image Guided

scholarly journals Upconversion NIR-II fluorophores for mitochondria-targeted cancer imaging and photothermal therapy

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Hui Zhou ◽  
Xiaodong Zeng ◽  
Anguo Li ◽  
Wenyi Zhou ◽  
Lin Tang ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Biomedical Applications ◽  
Cell Imaging ◽  
Upconversion Luminescence ◽  
Great Promise ◽  
Osteosarcoma Cells ◽  
Image Guided ◽  
Donor Acceptor ◽  
Subcellular Resolution

AbstractNIR-II fluorophores have shown great promise for biomedical applications with superior in vivo optical properties. To date, few small-molecule NIR-II fluorophores have been discovered with donor-acceptor-donor (D-A-D) or symmetrical structures, and upconversion-mitochondria-targeted NIR-II dyes have not been reported. Herein, we report development of D-A type thiopyrylium-based NIR-II fluorophores with frequency upconversion luminescence (FUCL) at ~580 nm upon excitation at ~850 nm. H4-PEG-PT can not only quickly and effectively image mitochondria in live or fixed osteosarcoma cells with subcellular resolution at 1 nM, but also efficiently convert optical energy into heat, achieving mitochondria-targeted photothermal cancer therapy without ROS effects. H4-PEG-PT has been further evaluated in vivo and exhibited strong tumor uptake, specific NIR-II signals with high spatial and temporal resolution, and remarkable NIR-II image-guided photothermal therapy. This report presents the first D-A type thiopyrylium NIR-II theranostics for synchronous upconversion-mitochondria-targeted cell imaging, in vivo NIR-II osteosarcoma imaging and excellent photothermal efficiency.

In vivo intracardiac OCT imaging through percutaneous access: towards image guided radio-frequency ablation

2012 ◽  
Author(s):  
Hui Wang ◽  
Wei Kang ◽  
Thomas Carrigan ◽  
Austin Bishop ◽  
Noah Rosenthal ◽  
...  
Keyword(s):  
Radio Frequency ◽  
Radio Frequency Ablation ◽  
Percutaneous Access ◽  
Image Guided ◽  
Oct Imaging
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