Iridium(iii) complexes as reaction based chemosensors for medical diagnostics

2018 ◽  
Vol 47 (43) ◽  
pp. 15278-15282 ◽  
Author(s):  
Dik-Lung Ma ◽  
Hing Pan NG ◽  
Suk-Yu Wong ◽  
Kasipandi Vellaisamy ◽  
Ke-Jia Wu ◽  
...  
Keyword(s):  
Medical Diagnostics ◽  
Luminescent Probes ◽  
Recent Developments

This frontier article introduces recent developments and applications of iridium(iii) complexes as luminescent probes for ions and biomolecules.

Recent developments in lanthanide-based luminescent probes

2014 ◽  
Vol 273-274 ◽  
pp. 201-212 ◽  
Author(s):  
Xiaohui Wang ◽  
Hongjin Chang ◽  
Juan Xie ◽  
Baozhou Zhao ◽  
Botong Liu ◽  
...  
Keyword(s):  
Luminescent Probes ◽  
Recent Developments

scholarly journals Luminescent probes for the bioimaging of small anionic species in vitro and in vivo

2015 ◽  
Vol 44 (14) ◽  
pp. 4547-4595 ◽  
Author(s):  
Trent D. Ashton ◽  
Katrina A. Jolliffe ◽  
Frederick M. Pfeffer
Keyword(s):  
Comprehensive Review ◽  
Luminescent Probes ◽  
Recent Developments ◽  
Anionic Species ◽  
Cover Art

This comprehensive review examines recent developments in the use of fluorescent/luminescent probes for the bioimaging of anionic species. Images in cover art reproduced with permission from ref. 290 and 306.

scholarly journals A Review on Solution-Processed Organic Phototransistors and Their Recent Developments

2021 ◽  
Author(s):  
Aybuke Tavasli ◽  
Betul Gurunlu ◽  
Dilara Gunturkun ◽  
Recep Isci ◽  
Sheida Faraji
Keyword(s):  
Field Effect Transistors ◽  
Point Of Care ◽  
Incident Light ◽  
Real Life ◽  
Medical Diagnostics ◽  
Organic Field Effect Transistors ◽  
Electrode Structure ◽  
Device Structure ◽  
Recent Developments ◽  
Reduction Characteristics

Today, more disciplines are intercepting each other, giving rise to “cross-disciplinary” research. Technological advancements in material science and device structure and production have paved the way towards development of new classes of multi-purpose sensory devices. Organic phototransistors (OPTs) are photo-activated sensors based on organic field-effect transistors that convert incident light signals into electrical signals. The organic semiconductor (OSC) layer and three-electrode structure of an OPT offer great advantages for light detection compared to conventional photodetectors and photodiodes, due to their signal amplification and noise reduction characteristics. Solution processing of the active layer enables mass production of OPT devices at significantly reduced cost. The chemical structure of OSCs can be modified accordingly to fulfil detection at various wavelengths for different purposes. Organic phototransistors have attracted substantial interest in a variety of fields, namely biomedical, medical diagnostics, healthcare, energy, security, and environmental monitoring. Lightweight and mechanically flexible and wearable OPTs are suitable alternatives not only at clinical levels but also for point-of-care and home-assisted usage. In this review, we aim to explain different types, working mechanism and figures of merit of organic phototransistors and highlight the recent advances from the literature on development and implementation of OPTs for a broad range of research and real-life applications.

Making sense of Lanthanide Luminescence

2005 ◽  
Vol 88 (2) ◽  
pp. 101-131 ◽  
Author(s):  
Martinus H.V. Werts
Keyword(s):  
Lanthanide Complexes ◽  
Near Infrared ◽  
Spectroscopic Studies ◽  
Medical Diagnostics ◽  
Lanthanide Ions ◽  
Luminescent Materials ◽  
Making Sense ◽  
Trivalent Lanthanide ◽  
Recent Developments ◽  
History Of

The luminescence of trivalent lanthanide ions has found applications in lighting, lasers, optical telecommunications, medical diagnostics, and various other fields. This introductory review presents the basics of organic and inorganic luminescent materials containing lanthanide ions, their applications, and some recent developments. After a brief history of the discovery, purification and early spectroscopic studies of the lanthanides, the radiative and nonradiative transitions of the 4f electrons in lanthanide ions are discussed. Lanthanide-doped phosphors, glasses and crystals as well as luminescent lanthanide complexes with organic ligands receive attention with respect to their preparation and their applications. Finally, two recent developments in the field of luminescent materials are addressed: near-infrared luminescent lanthanide complexes and lanthanide-doped nanoparticles.

scholarly journals Statistical Physics for Medical Diagnostics: Learning, Inference, and Optimization Algorithms

Diagnostics ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 972
Author(s):  
Abolfazl Ramezanpour ◽  
Andrew L. Beam ◽  
Jonathan H. Chen ◽  
Alireza Mashaghi
Keyword(s):  
Statistical Physics ◽  
Medical Diagnostics ◽  
Current Medical ◽  
Biochemical Networks ◽  
Disease States ◽  
Inference Algorithms ◽  
Recent Developments ◽  
Current Medical Practice ◽  
Medical Diagnostic ◽  
Macroscopic States

It is widely believed that cooperation between clinicians and machines may address many of the decisional fragilities intrinsic to current medical practice. However, the realization of this potential will require more precise definitions of disease states as well as their dynamics and interactions. A careful probabilistic examination of symptoms and signs, including the molecular profiles of the relevant biochemical networks, will often be required for building an unbiased and efficient diagnostic approach. Analogous problems have been studied for years by physicists extracting macroscopic states of various physical systems by examining microscopic elements and their interactions. These valuable experiences are now being extended to the medical field. From this perspective, we discuss how recent developments in statistical physics, machine learning and inference algorithms are coming together to improve current medical diagnostic approaches.

scholarly journals Artificial High Density Lipoprotein Nanoparticles in Cardiovascular Research

Molecules ◽  
2019 ◽  
Vol 24 (15) ◽  
pp. 2829 ◽  
Author(s):  
Kornmueller ◽  
Vidakovic ◽  
Prassl
Keyword(s):  
Self Assembly ◽  
Density Lipoprotein ◽  
Medical Diagnostics ◽  
High Density ◽  
High Density Lipoproteins ◽  
Special Focus ◽  
Structural Determinants ◽  
Cardiovascular Research ◽  
Recent Developments ◽  
Apo Ai

Lipoproteins are endogenous nanoparticles which are the major transporter of fats and cholesterol in the human body. They play a key role in the regulatory mechanisms of cardiovascular events. Lipoproteins can be modified and manipulated to act as drug delivery systems or nanocarriers for contrast agents. In particular, high density lipoproteins (HDL), which are the smallest class of lipoproteins, can be synthetically engineered either as nascent HDL nanodiscs or spherical HDL nanoparticles. Reconstituted HDL (rHDL) particles are formed by self-assembly of various lipids and apolipoprotein AI (apo-AI). A variety of substances including drugs, nucleic acids, signal emitting molecules, or dyes can be loaded, making them efficient nanocarriers for therapeutic applications or medical diagnostics. This review provides an overview about synthesis techniques, physicochemical properties of rHDL nanoparticles, and structural determinants for rHDL function. We discuss recent developments utilizing either apo-AI or apo-AI mimetic peptides for the design of pharmaceutical rHDL formulations. Advantages, limitations, challenges, and prospects for clinical translation are evaluated with a special focus on promising strategies for the treatment and diagnosis of atherosclerosis and cardiovascular diseases.

scholarly journals Recent Developments in Plasmonic Nanostructures for Metal Enhanced Fluorescence-Based Biosensing

Nanomaterials ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 1749 ◽  
Author(s):  
Mohsin Ali Badshah ◽  
Na Yoon Koh ◽  
Abdul Wasy Zia ◽  
Naseem Abbas ◽  
Zahra Zahra ◽  
...  
Keyword(s):  
Forensic Science ◽  
Basic Mechanism ◽  
Medical Diagnostics ◽  
Plasmonic Nanostructures ◽  
Fluorescence Signal ◽  
Enhanced Fluorescence ◽  
Metal Enhanced Fluorescence ◽  
Research Areas ◽  
Design Flexibility ◽  
Recent Developments

Metal-enhanced fluorescence (MEF) is a unique phenomenon of surface plasmons, where light interacts with the metallic nanostructures and produces electromagnetic fields to enhance the sensitivity of fluorescence-based detection. In particular, this enhancement in sensing capacity is of importance to many research areas, including medical diagnostics, forensic science, and biotechnology. The article covers the basic mechanism of MEF and recent developments in plasmonic nanostructures fabrication for efficient fluorescence signal enhancement that are critically reviewed. The implications of current fluorescence-based technologies for biosensors are summarized, which are in practice to detect different analytes relevant to food control, medical diagnostics, and forensic science. Furthermore, characteristics of existing fabrication methods have been compared on the basis of their resolution, design flexibility, and throughput. The future projections emphasize exploring the potential of non-conventional materials and hybrid fabrication techniques to further enhance the sensitivity of MEF-based biosensors.

scholarly journals Recent developments in nanowires for bio-applications from molecular to cellular levels

Lab on a Chip ◽  
2016 ◽  
Vol 16 (7) ◽  
pp. 1126-1138 ◽  
Author(s):  
Sakon Rahong ◽  
Takao Yasui ◽  
Noritada Kaji ◽  
Yoshinobu Baba
Keyword(s):  
Medical Diagnostics ◽  
Bioanalytical Chemistry ◽  
Recent Developments

This review highlights the most promising applications of nanowires for bioanalytical chemistry and medical diagnostics.

Trends in Electron Energy Loss Spectroscopy

1977 ◽  
Vol 35 ◽  
pp. 228-229
Author(s):  
C. Colliex ◽  
P. Trebbia
Keyword(s):  
Energy Loss ◽  
Electron Energy ◽  
Electron Energy Loss Spectroscopy ◽  
Materials Science ◽  
Analytical Technique ◽  
Recent Developments ◽  
Quantitative Results ◽  
Electron Microscopes ◽  
Electron Energy Loss ◽  
Primary Electrons

The physical foundations for the use of electron energy loss spectroscopy towards analytical purposes, seem now rather well established and have been extensively discussed through recent publications. In this brief review we intend only to mention most recent developments in this field, which became available to our knowledge. We derive also some lines of discussion to define more clearly the limits of this analytical technique in materials science problems.The spectral information carried in both low ( 0<ΔE<100eV ) and high ( >100eV ) energy regions of the loss spectrum, is capable to provide quantitative results. Spectrometers have therefore been designed to work with all kinds of electron microscopes and to cover large energy ranges for the detection of inelastically scattered electrons (for instance the L-edge of molybdenum at 2500eV has been measured by van Zuylen with primary electrons of 80 kV). It is rather easy to fix a post-specimen magnetic optics on a STEM, but Crewe has recently underlined that great care should be devoted to optimize the collecting power and the energy resolution of the whole system.

Filaments and membranes in the mitotic apparatus

1983 ◽  
Vol 41 ◽  
pp. 544-547
Author(s):  
Kent McDonald
Keyword(s):  
Intermediate Filaments ◽  
Mitotic Spindle ◽  
Mitotic Apparatus ◽  
Light Microscope Level ◽  
Microtubule Associated Proteins ◽  
Recent Developments ◽  
Associated Proteins ◽  
Force Generator ◽  
Spindle Function ◽  
Antibody Technology

At the light microscope level the recent developments and interest in antibody technology have permitted the localization of certain non-microtubule proteins within the mitotic spindle, e.g., calmodulin, actin, intermediate filaments, protein kinases and various microtubule associated proteins. Also, the use of fluorescent probes like chlorotetracycline suggest the presence of membranes in the spindle. Localization of non-microtubule structures in the spindle at the EM level has been less rewarding. Some mitosis researchers, e.g., Rarer, have maintained that actin is involved in mitosis movements though the bulk of evidence argues against this interpretation. Others suggest that a microtrabecular network such as found in chromatophore granule movement might be a possible force generator but there is little evidence for or against this view. At the level of regulation of spindle function, Harris and more recently Hepler have argued for the importance of studying spindle membranes. Hepler also believes that membranes might play a structural or mechanical role in moving chromosomes.

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