scholarly journals Impact of copper and iron binding properties on the anticancer activity of 8-hydroxyquinoline derived Mannich bases

2018 ◽  
Vol 47 (47) ◽  
pp. 17032-17045 ◽  
Author(s):  
Veronika F. S. Pape ◽  
Nóra V. May ◽  
G. Tamás Gál ◽  
István Szatmári ◽  
Flóra Szeri ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Mannich Bases ◽  
Iron Binding ◽  
Binding Properties

A relationship between pKa values, binding abilities to copper(ii) and iron(iii) and anticancer activity of 8-hydroxyquinoline derived Mannich bases.

scholarly journals Selective reduction of a disulphide bridge in hen ovotransferrin

1985 ◽  
Vol 228 (3) ◽  
pp. 661-665 ◽  
Author(s):  
J Williams ◽  
K Moreton ◽  
A D Goodearl
Keyword(s):  
Selective Reduction ◽  
Iron Binding ◽  
Thiol Groups ◽  
Native Protein ◽  
Brief Treatment ◽  
Disulphide Bridge ◽  
Binding Properties ◽  
Terminal Domain ◽  
Fluorescent Derivative

Brief treatment of iron-saturated hen ovotransferrin with dithiothreitol selectively cleaves the disulphide bridge between residues 478 and 671, which is in the C-terminal domain of the protein. The reduced alkylated protein is less stable than the native protein, and its iron-binding properties are different. A fluorescent derivative was prepared by coupling N-iodoacetyl-N'-(5-sulpho-1-naphthyl)ethylenediamine to the thiol groups.

The iron-binding properties of gastric juice

1969 ◽  
Vol 24 (1) ◽  
pp. 87-92 ◽  
Author(s):  
A. Jacobs ◽  
P.M. Miles
Keyword(s):  
Gastric Juice ◽  
Iron Binding ◽  
Binding Properties

Synthesis and characterization of Mannich bases of lawsone and their anticancer activity

2020 ◽  
Vol 50 (11) ◽  
pp. 1724-1735
Author(s):  
Pratik Nariya ◽  
Falguni Shukla ◽  
Hitarthi Vyas ◽  
Ranjitsinh Devkar ◽  
Sonal Thakore
Keyword(s):  
Anticancer Activity ◽  
Mannich Bases ◽  
Synthesis And Characterization

Iron‐Binding Properties of TTf, a Salt‐Induced Transferrin from the Alga Dunaliella salina

2003 ◽  
Vol 26 (10-11) ◽  
pp. 2081-2091 ◽  
Author(s):  
Michal Schwarz ◽  
Ada Zamir ◽  
Uri Pick
Keyword(s):  
Dunaliella Salina ◽  
Iron Binding ◽  
Binding Properties

Synthesis, Anion-Binding Properties, and In Vitro Anticancer Activity of Prodigiosin Analogues

2005 ◽  
Vol 117 (37) ◽  
pp. 6143-6146 ◽  
Author(s):  
Jonathan L. Sessler ◽  
Leah R. Eller ◽  
Won-Seob Cho ◽  
Sergios Nicolaou ◽  
Apolonio Aguilar ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Anion Binding ◽  
Binding Properties

scholarly journals The effect of salt concentration on the iron-binding properties of human transferrin

1982 ◽  
Vol 201 (3) ◽  
pp. 527-532 ◽  
Author(s):  
J Williams ◽  
N D Chasteen ◽  
K Moreton
Keyword(s):  
Salt Concentration ◽  
Binding Sites ◽  
Gel Electrophoresis ◽  
Polyacrylamide Gel Electrophoresis ◽  
Iron Binding ◽  
Iron Release ◽  
Equilibrium Conditions ◽  
Binding Properties ◽  
Kinetics Of ◽  
Terminal Site

The salt dependence of the iron-binding properties of transferrin was studied by urea/polyacrylamide-gel electrophoresis. The distribution of iron between the N-terminal and C-terminal binding sites under equilibrium conditions and the rates of release of iron from the two sites were studied. It was found that salt increases the thermodynamic stability of iron binding in the N-terminal site relative to the C-terminal site. Similar behaviour is observed for the kinetics of iron release, where salt retards the rate of removal of iron from the N-terminal site but facilitates removal from the C-terminal site.

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