Highly potent half-sandwich iridium and ruthenium complexes as lysosome-targeted imaging and anticancer agents

2018 ◽  
Vol 47 (44) ◽  
pp. 15772-15782 ◽  
Author(s):  
JuanJuan Li ◽  
Zhenzhen Tian ◽  
Zhishan Xu ◽  
Shumiao Zhang ◽  
Yaqian Feng ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Ruthenium Complexes ◽  
Targeted Imaging ◽  
Chelating Ligands ◽  
New Class ◽  
Half Sandwich

A new class of half-sandwich Ir and Ru compounds containing P^P-chelating ligands can be developed as potential multifunctional theranostic platforms that combine bioimaging and anticancer capabilities.

Half-Sandwich Iridium(III) and Ruthenium(II) Complexes Containing P^P-Chelating Ligands: A New Class of Potent Anticancer Agents with Unusual Redox Features

2018 ◽  
Vol 57 (4) ◽  
pp. 1705-1716 ◽  
Author(s):  
JuanJuan Li ◽  
Meng Tian ◽  
Zhenzhen Tian ◽  
Shumiao Zhang ◽  
Chao Yan ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Chelating Ligands ◽  
New Class ◽  
Half Sandwich ◽  
Redox Features

Rhodamine-modified fluorescent half-sandwich iridium and ruthenium complexes: potential application as bioimaging and anticancer agents

2019 ◽  
Vol 48 (15) ◽  
pp. 4788-4793 ◽  
Author(s):  
Wenli Ma ◽  
Lihua Guo ◽  
Zhenzhen Tian ◽  
Shumiao Zhang ◽  
Xiangdong He ◽  
...  
Keyword(s):  
Mechanism Of Action ◽  
Anticancer Agents ◽  
Potential Application ◽  
Ruthenium Complexes ◽  
Anticancer Complexes ◽  
Half Sandwich

Most half-sandwich metal anticancer complexes are non-fluorescent, which results in an uncertain mechanism of action (MoA).

Synthesis and Biological Evaluations of Organoruthenium Scaffolds: A Comprehensive Update

2018 ◽  
Vol 15 (2) ◽  
pp. 179-207
Author(s):  
Ashaparna Mondal ◽  
Priyankar Paira
Keyword(s):  
Singlet Oxygen ◽  
Anticancer Agents ◽  
Ruthenium Complexes ◽  
Chemotherapeutic Agents ◽  
Quantum Yields ◽  
Ros Generation ◽  
Standard Drug ◽  
Cellular Environment ◽  
Theranostic Agents

Background: Currently ruthenium complexes are immerging as effective anticancer agents due to their less toxicity, better antiproliferative and antimetastatic activity, better stability in cellular environment and most importantly variable oxidation and co-ordination states of ruthenium allows binding this molecule with a variety of ligands. So in past few years researchers have shifted their interest towards organoruthenium complexes having good fluorescent profile that may be applicable for cancer theranostics. Nowadays, photodynamic therapy has become more acceptable because of its easy and effective approach towards killing cancer cells. Objective: Objective of this review article is to shed light on synthesis, characterization, stability and fluorescence studies of various ruthenium [Ru(II) and Ru(III)] complexes and different bioactivity studies conducted with the synthesized compounds to test their candidacy as potent chemotherapeutic agents. Methods: Various heterocyclic ligands containing N,O and S as heteroatom mainly were prepared and subjected to complexation with ruthenium-p-cymene moiety. In most cases [Ru(η6-p-cymene)(µ-Cl)Cl]2 was used as ruthenium precursor and the reactions were conducted in various alcohol medium such as methanol, ethanol or propanol. The synthesized complexes were characterized by 1H NMR and 13C NMR spectroscopy, GC-MS, ESI-MS, elemental analysis and single crystal X-ray crystallography methods. Fluorescence study and stability study were conducted accordingly using water, PBS buffer or DMSO. Stable compounds were considered for cell viability studies. To study the efficacy of the compounds in ROS generation as photosensitizers, in few cases, singlet oxygen quantum yields in presence of light were calculated. Suitable compounds were selected for in vitro & in vivo antiproliferative, anti-invasive activity studies. Result: Many newly synthesized compounds were found to have less IC50 compared to a standard drug cysplatin. Those compounds were also stable preferably in physiological conditions. Good fluorescence profile and ROS generation ability were observed for few compounds. Conclusion: Numerous ruthenium complexes were developed which can be used as cancer theranostic agents. Few molecules were synthesized as photosensitizers which were supposed to generate reactive singlet oxygen species in targeted cellular environment in presence of a particular type of light and thereby ceasing cancer cell growth.

Multifunctional quantum dot–polypeptide hybrid nanogel for targeted imaging and drug delivery

Nanoscale ◽  
2014 ◽  
Vol 6 (19) ◽  
pp. 11282-11292 ◽  
Author(s):  
Jie Yang ◽  
Ming-Hao Yao ◽  
Lang Wen ◽  
Ji-Tao Song ◽  
Ming-Zhen Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Quantum Dot ◽  
Cancer Diagnosis ◽  
Targeted Imaging ◽  
New Class

A new class of multifunctional quantum dot (QD)–polypeptide hybrid nanogel with targeted imaging and drug delivery properties is reported as a nanocarrier for use in cancer diagnosis, imaging, and therapy.

Fluorescent half-sandwich phosphine-sulfonate iridium(III) and ruthenium(II) complexes as potential lysosome-targeted anticancer agents

2019 ◽  
Vol 162 ◽  
pp. 821-830 ◽  
Author(s):  
Qing Du ◽  
Yuliang Yang ◽  
Lihua Guo ◽  
Meng Tian ◽  
Xingxing Ge ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Half Sandwich

ChemInform Abstract: Half-Sandwich Arene Ruthenium Complexes: Synthetic Strategies and Relevance in Catalysis

ChemInform ◽  
2014 ◽  
Vol 45 (15) ◽  
pp. no-no
Author(s):  
Prashant Kumar ◽  
Rakesh Kumar Gupta ◽  
Daya Shankar Pandey
Keyword(s):  
Ruthenium Complexes ◽  
Half Sandwich

scholarly journals Developments in Platinum-Group Metals as Dual Antibacterial and Anticancer Agents

2019 ◽  
Vol 2019 ◽  
pp. 1-18 ◽  
Author(s):  
Ayodele T. Odularu ◽  
Peter A. Ajibade ◽  
Johannes Z. Mbese ◽  
Opeoluwa O. Oyedeji
Keyword(s):  
Anticancer Drugs ◽  
Anticancer Agents ◽  
Coordination Compounds ◽  
Biological Activities ◽  
Platinum Group Metals ◽  
Biological Applications ◽  
Efficient Delivery ◽  
History Of ◽  
Platinum Group ◽  
Half Sandwich

Platinum-group (PG) complexes have been used as antibacterial and anticancer agents since the discovery of cisplatin. The science world still requires improvement on these complexes because of multidrug and antineoplastic resistances. This review observes discoverers and history of these platinum-group metals (PGMs), as well as their beneficial applications. The focus of this study was biological applications of PGMs in relation to human health. Sandwich and half-sandwich PGM coordination compounds and their metal nanoparticles give improved results for biological activities by enhancing efficient delivery of both antibacterial and anticancer drugs, as well as luminescent bioimaging (biomarkers) for biological identifications.

Triazolopyrimidinium salts: discovery of a new class of agents for cancer therapy

2020 ◽  
Vol 12 (5) ◽  
pp. 387-402
Author(s):  
Mariateresa Badolato ◽  
Fabrizio Manetti ◽  
Antonio Garofalo ◽  
Francesca Aiello
Keyword(s):  
Anticancer Agents ◽  
Docking Studies ◽  
In Vitro Models ◽  
Sh2 Domain ◽  
Activity Profile ◽  
Cancer Cell Growth ◽  
New Class ◽  
Src Homology 2 ◽  
Src Homology

Aim: The [1,2,4]triazolo[1,5- a]pyrimidine core is highly privileged in medicinal chemistry due to its versatile pharmacological activity profile. Recently, the search for novel anticancer agents has focused on [1,2,4]triazolo[1,5- a]pyrimidine derivatives. Results: Our hit functionalization has led to the discovery of new [1,2,4]triazolo[1,5- a]pyrimidinium salts with potential anticancer activity. Among a small library of molecules, compound 9 significantly inhibits cancer cell growth in a panel of in vitro models. Molecular docking studies and preliminary binding assay have displayed that 9 could directly bind the Src homology 2 (SH2) domain of STAT3 protein. Conclusion: Compound 9 is a novel promising lead compound that motivates additional evaluation of [1,2,4]triazolo[1,5- a]pyrimidinium salts as novel potential chemotherapeutics.

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