scholarly journals Developments in Platinum-Group Metals as Dual Antibacterial and Anticancer Agents

2019 ◽  
Vol 2019 ◽  
pp. 1-18 ◽  
Author(s):  
Ayodele T. Odularu ◽  
Peter A. Ajibade ◽  
Johannes Z. Mbese ◽  
Opeoluwa O. Oyedeji
Keyword(s):  
Anticancer Drugs ◽  
Anticancer Agents ◽  
Coordination Compounds ◽  
Biological Activities ◽  
Platinum Group Metals ◽  
Biological Applications ◽  
Efficient Delivery ◽  
History Of ◽  
Platinum Group ◽  
Half Sandwich

Platinum-group (PG) complexes have been used as antibacterial and anticancer agents since the discovery of cisplatin. The science world still requires improvement on these complexes because of multidrug and antineoplastic resistances. This review observes discoverers and history of these platinum-group metals (PGMs), as well as their beneficial applications. The focus of this study was biological applications of PGMs in relation to human health. Sandwich and half-sandwich PGM coordination compounds and their metal nanoparticles give improved results for biological activities by enhancing efficient delivery of both antibacterial and anticancer drugs, as well as luminescent bioimaging (biomarkers) for biological identifications.

scholarly journals Algae as potential repository of anti cancerous natural compounds

2017 ◽  
Vol 9 (2) ◽  
Author(s):  
Ankita Mridha ◽  
Santanu Paul
Keyword(s):  
Anticancer Agents ◽  
Biological Activities ◽  
Leukemia Cell ◽  
Relevant Information ◽  
Cancer Cell Growth ◽  
History Of ◽  
History Of Use ◽  
Promising Source

<p>Algae constitute a promising source of novel compounds with potential as human therapeutic agents. In particular, algae have been considered as a potential source of new bio-active compound. Algae possess several biological activities, including anticancer activity. This review provides a comprehensive report on the several genera of algae belonging to Chlorophyceae, Pheophyceae and Rhodophyceae having anti-proliferative, apoptotic, anti angiogenic as well as cytotoxic efficacy and their mode of action <em>in vitro</em> as well as <em>in vivo</em> condition. Algae are extensively used as functional foods and medicinal herbs, and have a long history of use in Asian countries. Many algae have been used for the treatment of cancer, many crude or partially purified polysaccharides from various brown, green, and red algae have been tested for their antitumor activities. Relevant information was collected from scientific journals, books, and reports via library and electronic search using Medline, Pubmed, Science Direct, and Scopus. The different extracts with some other solvent shows a huge anti-proliferative action on different cancer as well as on different leukemia cell lines. Here we focus on several bioactive compounds that have been derived as well as characterized from different genera of algae and there mechanism of inhibiting cancer cell growth. Considering the ability of the golden treasure present in algae to act against different cancers, this review highlights the potential use of algae as anticancer agents.</p>

Transition metal substituted sandwich-type polyoxometalates with a strong metal–C (imidazole) bond as anticancer agents

2019 ◽  
Vol 55 (8) ◽  
pp. 1096-1099 ◽  
Author(s):  
Hongxia Zhao ◽  
Li Tao ◽  
Fengmin Zhang ◽  
Ying Zhang ◽  
Yanqing Liu ◽  
...  
Keyword(s):  
Transition Metal ◽  
Anticancer Drugs ◽  
Anticancer Agents ◽  
Biological Activities ◽  
Pivotal Role ◽  
Carbon Bond ◽  
Sandwich Type ◽  
Sandwich Type Polyoxometalates

The metal–carbon bond plays a pivotal role in the structural stabilities and biological activities of metal-based anticancer drugs. The strong M–Cimi bond is first introduced into sandwich-type POMs [Na0.7M5.3(H2O)2(imi)2(Himi)(SbW9O33)2]6−, (M = NiII (1), CoII (2), imi = imidazole).

scholarly journals Homo- and Hetero-Oligonuclear Complexes of Platinum Group Metals (PGM) Coordinated by Imine Schiff Base Ligands

2020 ◽  
Vol 21 (10) ◽  
pp. 3493 ◽  
Author(s):  
Barbara Miroslaw
Keyword(s):  
Schiff Base ◽  
Hybrid Materials ◽  
Coordination Compounds ◽  
Catalytic Properties ◽  
Platinum Group Metals ◽  
Schiff Base Ligands ◽  
Polynuclear Species ◽  
Platinum Group ◽  
Construction Strategies ◽  
Imine Ligands

Chemistry of Schiff base (SB) ligands began in 1864 due to the discovery made by Hugo Schiff (Schiff, H., Justus Liebigs Ann. der Chemie 1864, 131 (1), 118–119). However, there is still a vivid interest in coordination compounds based on imine ligands. The aim of this paper is to review the most recent concepts on construction of homo- and hetero-oligonuclear Schiff base coordination compounds narrowed down to the less frequently considered complexes of platinum group metals (PGM). The combination of SB and PGM in oligonuclear entities has several advantages over mononuclear or polynuclear species. Such complexes usually exhibit better electroluminescent, magnetic and/or catalytic properties than mononuclear ones due to intermetallic interactions and frequently have better solubility than polymers. Various construction strategies of oligodentate imine ligands for coordination of PGM are surveyed including simple imine ligands, non-innocent 1,2-diimines, chelating imine systems with additional N/O/S atoms, classic N2O2-compartmental Schiff bases and their modifications resulting in acyclic fused ligands, macrocycles such as calixsalens, metallohelical structures, nano-sized molecular wheels and hybrid materials incorporating mesoionic species. Co-crystallization and formation of metallophilic interactions to extend the mononuclear entities up to oligonuclear coordination species are also discussed.

Recent Advancement in the One-Pot Synthesis of the Tri-Substituted Methanes (TRSMs) and Their Biological Applications

2021 ◽  
Vol 18 ◽  
Author(s):  
Monika Verma ◽  
Ajay Thakur ◽  
Renu Sharma ◽  
Ruchi Bharti
Keyword(s):  
Literature Review ◽  
Biological Activities ◽  
Biological Applications ◽  
One Pot ◽  
One Pot Synthesis ◽  
Wide Range ◽  
Recent Advancement ◽  
History Of ◽  
The One ◽  
Insight Into

: The history of tri-substituted methanes (TRSMs) in chemical industries is much older. Tri-substituted methanes were previously used as dyes in the chemical industries. Still, there is a significant surge in researchers' interest in them due to their wide range of bioactivities. Tri-substituted methane derivatives show a wide range of biological activities like anti-tumor, antimicrobial, antibiofilm, antioxidant, anti-inflammatory, anti-arthritic activities. Due to the wide range of medicinal applications shown by tri-substituted methanes, most of the methodologies reported in the literature for the synthesis of TRSMs are focused on the one-pot method. This review explored the recently reported one-pot processes for synthesizing tri-substituted methanes and their various medicinal applications. Based on the substitution attached to the -CH carbon, this review categorizes them into two major classes: (I) symmetrical and (II) unsymmetrical trisubstituted methanes. In addition, this review gives an insight into the growing opportunities for the construction of trisubstituted scaffolds via one-pot methodologies. To the best of our knowledge, no one has yet reported a review on the one-pot synthesis of TRSMs. Therefore, here we present a brief literature review of the synthesis of both symmetrical and unsymmetrical TRSMs covering various one-pot methodologies along with their medicinal applications.

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