Synthesis, cytotoxic activity and DNA interaction studies of new dinuclear platinum(ii) complexes with an aromatic 1,5-naphthyridine bridging ligand: DNA binding mode of polynuclear platinum(ii) complexes in relation to the complex structure

2018 ◽  
Vol 47 (42) ◽  
pp. 15091-15102 ◽  
Author(s):  
Bata Konovalov ◽  
Marija D. Živković ◽  
Jelena Z. Milovanović ◽  
Dragana B. Djordjević ◽  
Aleksandar N. Arsenijević ◽  
...  
Keyword(s):  
Dna Binding ◽  
Cytotoxic Activity ◽  
Complex Structure ◽  
Binding Mode ◽  
Dna Interaction ◽  
Bridging Ligand ◽  
Interaction Studies ◽  
Dinuclear Platinum

[{Pt(L)Cl}2(μ-1,5-nphe)]2+ complexes have been reported.

scholarly journals Novel 1,3,4-thiadiazole–chalcone hybrids containing catechol moiety: synthesis, antioxidant activity, cytotoxicity and DNA interaction studies

MedChemComm ◽  
2018 ◽  
Vol 9 (10) ◽  
pp. 1679-1697 ◽  
Author(s):  
Katarina Jakovljević ◽  
Milan D. Joksović ◽  
Ivana Z. Matić ◽  
Nina Petrović ◽  
Tatjana Stanojković ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Dna Binding ◽  
Dna Interaction ◽  
Binding Activity ◽  
Dna Binding Activity ◽  
Interaction Studies ◽  
Catechol Moiety

1,3,4-Thiadiazole compounds containing catechol moiety and chalcone motif are synthesized and examined for antioxidant activity, cytotoxicity and DNA-binding activity.

Electrochemical, mechanistic, and DFT studies of amine derived diphosphines containing Ru(ii)–cymene complexes with potent in vitro cytotoxic activity against HeLa and triple-negative breast cancer cells MDA-MB-231

2020 ◽  
Vol 49 (45) ◽  
pp. 16498-16514
Author(s):  
Juliana P. da Silva ◽  
Otávio Fuganti ◽  
M. Gabriela Kramer ◽  
Gianella Facchin ◽  
Lucas E. N. Aquino ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cytotoxic Activity ◽  
Cancer Cells ◽  
Triple Negative Breast Cancer ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
Dna Interaction ◽  
Dft Studies ◽  
Interaction Studies

Electrochemical/chemical, cytotoxic and DNA interaction studies of P–NR–P containing ruthenium–cymene complexes [RuCl(η6-p-cymene)(P–NR–P)]X.

scholarly journals Interstrand DNA covalent binding of two dinuclear Ru(ii) complexes. Influence of the extra ring of the bridging ligand on the DNA interaction and cytotoxic activity

2017 ◽  
Vol 46 (11) ◽  
pp. 3611-3622 ◽  
Author(s):  
Héctor J. Lozano ◽  
Natalia Busto ◽  
Gustavo Espino ◽  
Arancha Carbayo ◽  
José M. Leal ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Covalent Binding ◽  
Dna Interaction ◽  
Bridging Ligand ◽  
Interstrand Crosslinking

The quinones naphthazarin and quinizarin intercalate into DNA whereas their p-cymene di-ruthenium(ii) complexes bind covalently via interstrand crosslinking.

Synthesis, cytotoxic activity and DNA-interaction studies of novel anthraquinone–thiosemicarbazones with tautomerizable methylene group

2013 ◽  
Vol 64 ◽  
pp. 228-238 ◽  
Author(s):  
Violeta Marković ◽  
Ana Janićijević ◽  
Tatjana Stanojković ◽  
Branka Kolundžija ◽  
Dušan Sladić ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Dna Interaction ◽  
Interaction Studies ◽  
Methylene Group

DNA Binding Mode of Transition Metal Complexes, A Relationship to Tumor Cell Toxicity

2014 ◽  
Vol 21 (26) ◽  
pp. 3081-3094 ◽  
Author(s):  
M. Ashfaq ◽  
T. Najam ◽  
S.S.A. Shah ◽  
M.M. Ahmad ◽  
S. Shaheen ◽  
...  
Keyword(s):  
Dna Binding ◽  
Transition Metal ◽  
Tumor Cell ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Binding Mode ◽  
Cell Toxicity

scholarly journals Mechanism of NanR gene repression and allosteric induction of bacterial sialic acid metabolism

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Christopher R. Horne ◽  
Hariprasad Venugopal ◽  
Santosh Panjikar ◽  
David M. Wood ◽  
Amy Henrickson ◽  
...  
Keyword(s):  
Sialic Acid ◽  
Dna Binding ◽  
Protein Interactions ◽  
Acid Metabolism ◽  
Environmental Changes ◽  
Dna Interaction ◽  
Protein Protein Interactions ◽  
Nutrient Source ◽  
Cryo Electron Microscopy ◽  
Close Proximity

AbstractBacteria respond to environmental changes by inducing transcription of some genes and repressing others. Sialic acids, which coat human cell surfaces, are a nutrient source for pathogenic and commensal bacteria. The Escherichia coli GntR-type transcriptional repressor, NanR, regulates sialic acid metabolism, but the mechanism is unclear. Here, we demonstrate that three NanR dimers bind a (GGTATA)3-repeat operator cooperatively and with high affinity. Single-particle cryo-electron microscopy structures reveal the DNA-binding domain is reorganized to engage DNA, while three dimers assemble in close proximity across the (GGTATA)3-repeat operator. Such an interaction allows cooperative protein-protein interactions between NanR dimers via their N-terminal extensions. The effector, N-acetylneuraminate, binds NanR and attenuates the NanR-DNA interaction. The crystal structure of NanR in complex with N-acetylneuraminate reveals a domain rearrangement upon N-acetylneuraminate binding to lock NanR in a conformation that weakens DNA binding. Our data provide a molecular basis for the regulation of bacterial sialic acid metabolism.

DNA binding interaction studies of flavonoid complexes of Cu(II) and Fe(II) and determination of their chemotherapeutic potential

2019 ◽  
Vol 496 ◽  
pp. 119048
Author(s):  
Erum Jabeen ◽  
Naveed Kausar Janjua ◽  
Safeer Ahmed ◽  
Iftikhar Tahiri ◽  
Muhammad Kashif ◽  
...  
Keyword(s):  
Dna Binding ◽  
Binding Interaction ◽  
Interaction Studies
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