DNA interaction studies of a platinum (II) complex containing an antiviral drug, ribavirin: The effect of metal on DNA binding

2012 ◽  
Vol 96 ◽  
pp. 723-728 ◽  
Author(s):  
Nahid Shahabadi ◽  
Zeinab Mirzaei kalar ◽  
Neda Hosseinpour Moghadam
Keyword(s):  
Dna Binding ◽  
Antiviral Drug ◽  
Dna Interaction ◽  
Interaction Studies

scholarly journals Novel 1,3,4-thiadiazole–chalcone hybrids containing catechol moiety: synthesis, antioxidant activity, cytotoxicity and DNA interaction studies

MedChemComm ◽  
2018 ◽  
Vol 9 (10) ◽  
pp. 1679-1697 ◽  
Author(s):  
Katarina Jakovljević ◽  
Milan D. Joksović ◽  
Ivana Z. Matić ◽  
Nina Petrović ◽  
Tatjana Stanojković ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Dna Binding ◽  
Dna Interaction ◽  
Binding Activity ◽  
Dna Binding Activity ◽  
Interaction Studies ◽  
Catechol Moiety

1,3,4-Thiadiazole compounds containing catechol moiety and chalcone motif are synthesized and examined for antioxidant activity, cytotoxicity and DNA-binding activity.

Functionalization of γ-Fe2O3@SiO2 nanoparticles using the antiviral drug zidovudine: synthesis, characterization, in vitro cytotoxicity and DNA interaction studies

RSC Advances ◽  
2016 ◽  
Vol 6 (77) ◽  
pp. 73605-73616 ◽  
Author(s):  
Nahid Shahabadi ◽  
Monireh Falsafi ◽  
Foroozan Feizi ◽  
Reza Khodarahmi
Keyword(s):  
Magnetic Nanoparticles ◽  
Drug Targeting ◽  
Antiviral Drug ◽  
Sio2 Nanoparticles ◽  
Dna Interaction ◽  
In Vitro Cytotoxicity ◽  
Biological Applications ◽  
Interaction Studies

The aim of this study was to design and prepare γ-Fe2O3@SiO2-zidovudine magnetic nanoparticles (MNPs) for magnetic guided drug targeting and biological applications.

Synthesis, cytotoxic activity and DNA interaction studies of new dinuclear platinum(ii) complexes with an aromatic 1,5-naphthyridine bridging ligand: DNA binding mode of polynuclear platinum(ii) complexes in relation to the complex structure

2018 ◽  
Vol 47 (42) ◽  
pp. 15091-15102 ◽  
Author(s):  
Bata Konovalov ◽  
Marija D. Živković ◽  
Jelena Z. Milovanović ◽  
Dragana B. Djordjević ◽  
Aleksandar N. Arsenijević ◽  
...  
Keyword(s):  
Dna Binding ◽  
Cytotoxic Activity ◽  
Complex Structure ◽  
Binding Mode ◽  
Dna Interaction ◽  
Bridging Ligand ◽  
Interaction Studies ◽  
Dinuclear Platinum

[{Pt(L)Cl}2(μ-1,5-nphe)]2+ complexes have been reported.

DNA Interaction Studies of an Antiviral Drug, Ribavirin, Using Different Instrumental Methods

2012 ◽  
Vol 31 (5) ◽  
pp. 876-882 ◽  
Author(s):  
Nahid Shahabadi ◽  
Zeinab Mirzaei kalar ◽  
Asad Vaisi-Raygani
Keyword(s):  
Antiviral Drug ◽  
Dna Interaction ◽  
Interaction Studies ◽  
Instrumental Methods

scholarly journals Mechanism of NanR gene repression and allosteric induction of bacterial sialic acid metabolism

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Christopher R. Horne ◽  
Hariprasad Venugopal ◽  
Santosh Panjikar ◽  
David M. Wood ◽  
Amy Henrickson ◽  
...  
Keyword(s):  
Sialic Acid ◽  
Dna Binding ◽  
Protein Interactions ◽  
Acid Metabolism ◽  
Environmental Changes ◽  
Dna Interaction ◽  
Protein Protein Interactions ◽  
Nutrient Source ◽  
Cryo Electron Microscopy ◽  
Close Proximity

AbstractBacteria respond to environmental changes by inducing transcription of some genes and repressing others. Sialic acids, which coat human cell surfaces, are a nutrient source for pathogenic and commensal bacteria. The Escherichia coli GntR-type transcriptional repressor, NanR, regulates sialic acid metabolism, but the mechanism is unclear. Here, we demonstrate that three NanR dimers bind a (GGTATA)3-repeat operator cooperatively and with high affinity. Single-particle cryo-electron microscopy structures reveal the DNA-binding domain is reorganized to engage DNA, while three dimers assemble in close proximity across the (GGTATA)3-repeat operator. Such an interaction allows cooperative protein-protein interactions between NanR dimers via their N-terminal extensions. The effector, N-acetylneuraminate, binds NanR and attenuates the NanR-DNA interaction. The crystal structure of NanR in complex with N-acetylneuraminate reveals a domain rearrangement upon N-acetylneuraminate binding to lock NanR in a conformation that weakens DNA binding. Our data provide a molecular basis for the regulation of bacterial sialic acid metabolism.

DNA binding interaction studies of flavonoid complexes of Cu(II) and Fe(II) and determination of their chemotherapeutic potential

2019 ◽  
Vol 496 ◽  
pp. 119048
Author(s):  
Erum Jabeen ◽  
Naveed Kausar Janjua ◽  
Safeer Ahmed ◽  
Iftikhar Tahiri ◽  
Muhammad Kashif ◽  
...  
Keyword(s):  
Dna Binding ◽  
Binding Interaction ◽  
Interaction Studies

Synthesis, characterization and DNA interaction studies of CrIII products isolated from CrVI reduction with —SH containing molecules

Polyhedron ◽  
1996 ◽  
Vol 15 (5-6) ◽  
pp. 765-774 ◽  
Author(s):  
Sharada P. Kaiwar ◽  
Alavattam Sreedhara ◽  
Meenakshi S.S. Raghavan ◽  
Chebrolu P. Rao ◽  
Vasant Jadhav ◽  
...  
Keyword(s):  
Dna Interaction ◽  
Interaction Studies
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