scholarly journals Harnessing asymmetric N-heterocyclic carbene ligands to optimise SABRE hyperpolarisation

2018 ◽  
Vol 8 (19) ◽  
pp. 4925-4933 ◽  
Author(s):  
Chin Min Wong ◽  
Marianna Fekete ◽  
Rhianna Nelson-Forde ◽  
Mark R. D. Gatus ◽  
Peter J. Rayner ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Small Molecules ◽  
Signal Amplification ◽  
Exchange Process ◽  
Carbene Ligands

The catalytic signal amplification by reversible exchange process is used widely to improve the magnetic resonance detectability of small molecules by hyperpolarisation.

scholarly journals Metabolomics in nutrition research–a powerful window into nutritional metabolism

2016 ◽  
Vol 60 (5) ◽  
pp. 451-458 ◽  
Author(s):  
Lorraine Brennan
Keyword(s):  
Mass Spectrometry ◽  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Data Acquisition ◽  
Small Molecules ◽  
Biological Samples ◽  
Metabolic Pathways ◽  
Recent Trend ◽  
Disease States ◽  
Nutrition Research

Metabolomics is the study of small molecules present in biological samples. In recent years it has become evident that such small molecules, called metabolites, play a key role in the development of disease states. Furthermore, metabolomic applications can reveal information about alterations in certain metabolic pathways under different conditions. Data acquisition in metabolomics is usually performed using nuclear magnetic resonance (NMR)-based approaches or mass spectrometry (MS)-based approaches with a more recent trend including the application of multiple platforms in order to maximise the coverage in terms of metabolites measured. The application of metabolomics is rapidly increasing and the present review will highlight applications in nutrition research.

SABRE Hyperpolarization of Bipyridine Stabilized Ir-Complex at High, Low and Ultralow Magnetic Fields

2017 ◽  
Vol 231 (3) ◽  
Author(s):  
Andrey N. Pravdivtsev
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Magnetic Fields ◽  
Dynamic Nuclear Polarization ◽  
Signal Amplification ◽  
Nuclear Polarization ◽  
Optical Pumping ◽  
Spin Exchange ◽  
Spin Exchange Optical Pumping ◽  
Wide Range

AbstractA strong limitation of nuclear magnetic resonance is its low inherent sensitivity that can be overcome by using an appropriate hyperpolarization technique. Presently, dynamic nuclear polarization and spin-exchange optical pumping are the only hyperpolarization techniques that are used in applied medicine. However, both are relatively complex in use and expensive. Here we present a modification of the signal amplification by reversible exchange (SABRE) hyperpolarization method – SABRE on stabilized Ir-complexes. A stabilized Ir-complex (here we used bipyridine for stabilization) can be hyperpolarized in a wide range of magnetic fields from a few μT upto 10 T with

Target-directed enzyme-free dual-amplification DNA circuit for rapid signal amplification

2020 ◽  
Vol 8 (47) ◽  
pp. 10770-10775
Author(s):  
Chao Xing ◽  
Ziyi Chen ◽  
Cheng Zhang ◽  
Jun Wang ◽  
Chunhua Lu
Keyword(s):  
Nucleic Acids ◽  
Small Molecules ◽  
Signal Amplification ◽  
Fluorescence Analysis ◽  
Single Step ◽  
Hybridization Chain Reaction ◽  
Chain Reaction ◽  
Dual Amplification

An enzyme-free, single-step and rapid signal amplification DNA circuit was developed by integrating target-directed entropy-driven catalysis and hybridization chain reaction for fluorescence analysis of nucleic acids and small molecules.

Graphene Signal Amplification for Sensitive and Real-Time Fluorescence Anisotropy Detection of Small Molecules

2013 ◽  
Vol 85 (3) ◽  
pp. 1424-1430 ◽  
Author(s):  
Jinhua Liu ◽  
Changyao Wang ◽  
Ying Jiang ◽  
Yaping Hu ◽  
Jishan Li ◽  
...  
Keyword(s):  
Small Molecules ◽  
Real Time ◽  
Fluorescence Anisotropy ◽  
Signal Amplification

scholarly journals Small Molecules Bound to Unique Sites in the Target Protein Binding Cleft of Calcium-Bound S100B As Characterized by Nuclear Magnetic Resonance and X-ray Crystallography

Biochemistry ◽  
2009 ◽  
Vol 48 (26) ◽  
pp. 6202-6212 ◽  
Author(s):  
Thomas H. Charpentier ◽  
Paul T. Wilder ◽  
Melissa A. Liriano ◽  
Kristen M. Varney ◽  
Shijun Zhong ◽  
...  
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Protein Binding ◽  
Small Molecules ◽  
Target Protein ◽  
X Ray ◽  
X Ray Crystallography ◽  
Binding Cleft ◽  
Nuclear Magnetic

scholarly journals Signal Amplification by Reversible Exchange for COVID-19 Antiviral Drug Candidates

2020 ◽  
Author(s):  
HyeJin Jeong ◽  
Sein Min ◽  
Heelim Chae ◽  
Sara Kim ◽  
Gunwoo Lee ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Signal Amplification ◽  
Antiviral Drug ◽  
Polarization Transfer ◽  
Future Research ◽  
Resonance Imaging ◽  
Long Distance ◽  
Isotope Labelling ◽  
Drug Candidates ◽  
Molecular Scale

<p></p><p>Several drug candidates have been proposed and tested as the latest clinical treatment for the coronavirus pneumonia (COVID-19). Chloroquine, hydroxychloroquine, ritonavir/lopinavir, and favipiravir are proved to be effective after treatment. The hyperpolarization technique presents an ability to further understand the roles of these drugs at the molecular scale and applications in nuclear magnetic resonance/magnetic resonance imaging (NMR/MRI). This technique may provide new opportunities in diagnosis and biomedical research to cope with COVID-19. Signal amplification by reversible exchange (SABRE)-based hyperpolarization studies on large-sized drug candidates were carried out. We observed hyperpolarized proton signals from whole structures, due to the unprecedented long-distance polarization transfer by <i>para</i>-hydrogen. We also found that the optimum magnetic field for the maximum polarization transfer yield was dependent on the molecular structure. Therefore, future research on isotope labelling and polarization transfer on long T1 time nuclei including clinical perspectives can help us overcome this worldwide pandemic.</p><p></p>

Substituent Influences on the NMR Signal Amplification of Ir Complexes with Heterocyclic Carbene Ligands

2019 ◽  
Vol 50 (7) ◽  
pp. 895-902 ◽  
Author(s):  
Sara Hadjiali ◽  
Roman Savka ◽  
Markus Plaumann ◽  
Ute Bommerich ◽  
Sarah Bothe ◽  
...  
Keyword(s):  
Signal Amplification ◽  
Carbene Ligands

A 19F nuclear magnetic resonance study of the exchange of the fluoro ligands of the tetrafluoroberyllium(II) ion

1977 ◽  
Vol 30 (2) ◽  
pp. 271 ◽  
Author(s):  
SF Lincoln ◽  
AC Sandercock ◽  
DR Stranks
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Exchange Rate ◽  
Magnetic Resonance ◽  
Exchange Process ◽  
Nuclear Magnetic Resonance Study ◽  
Magnetic Resonance Study ◽  
Rate Law ◽  
The Exchange Rate ◽  
Nuclear Magnetic

A 19F N.M.R. study is reported of the exchange of the fluoro ligands of [BeF4]2-. The exchange rate law is: ����������� rate = kobs4[BeF42-] = k'4[BeF42-]+ k''4[BeF42-][BeF3H2O-] where k'(298 K) = 69�3 s-1, ΔH‡ = 30�3 kJ mol-1, ΔS‡ = -110�10 J mol-1 K-1 and k''(298 K) = (1.6�0.5)×103 dm3 mol-1 s-1, ΔH‡ = 26�3 kJ mol-1, ΔS‡ = - 96�9 J mol-1 K-1. The k' exchange process appears to be predominantly dissociative in nature, and the k'' exchange process apparently proceeds through a fluoro bridged species [Be2F7]2-.

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