Macromolecular crowding and the importance of proper hydration for the structure and dynamics of protein solutions

2018 ◽  
Vol 20 (29) ◽  
pp. 19581-19594 ◽  
Author(s):  
Philipp Honegger ◽  
Michael Schmollngruber ◽  
Othmar Steinhauser
Keyword(s):  
Macromolecular Crowding ◽  
Protein Solutions ◽  
Protein Hydration ◽  
Special Focus ◽  
Computational Studies ◽  
Dielectric Spectra ◽  
Structure And Dynamics

Extensive computational studies of ubiquitin crowding with a special focus on protein hydration directly visible in dielectric spectra.

Towards capturing cellular complexity: combining encapsulation and macromolecular crowding in a reverse micelle

2019 ◽  
Vol 21 (15) ◽  
pp. 8108-8120 ◽  
Author(s):  
Philipp Honegger ◽  
Othmar Steinhauser
Keyword(s):  
Reverse Micelle ◽  
Macromolecular Crowding ◽  
Biological Cells ◽  
Structure And Dynamics ◽  
Orientational Structure

This paper studies the orientational structure and dynamics of multi-protein systems under confinement and discusses the implications on biological cells.

Computational Studies of Structure and Dynamics of Clathrate Inhibitor Monomers in Solution

2007 ◽  
Vol 46 (1) ◽  
pp. 131-142 ◽  
Author(s):  
Diego A. Gómez Gualdrón ◽  
Santiago Aparicio-Martínez ◽  
Perla B. Balbuena
Keyword(s):  
Computational Studies ◽  
Structure And Dynamics

scholarly journals Structure and Dynamics of Protein Hydration in the Low-Hydration State

1999 ◽  
Vol 39 (supplement) ◽  
pp. S155
Author(s):  
K. Ando ◽  
Y. Seki ◽  
S. Kidokoro ◽  
K. Soda
Keyword(s):  
Protein Hydration ◽  
Structure And Dynamics ◽  
Hydration State

scholarly journals The more the merrier: effects of macromolecular crowding on the structure and dynamics of biological membranes

FEBS Journal ◽  
2020 ◽  
Vol 287 (23) ◽  
pp. 5039-5067 ◽  
Author(s):  
Maryna Löwe ◽  
Milara Kalacheva ◽  
Arnold J. Boersma ◽  
Alexej Kedrov
Keyword(s):  
Biological Membranes ◽  
Macromolecular Crowding ◽  
Structure And Dynamics

scholarly journals Pressure effects on collective density fluctuations in water and protein solutions

2017 ◽  
Vol 114 (43) ◽  
pp. 11410-11415 ◽  
Author(s):  
Daniela Russo ◽  
Alessio Laloni ◽  
Alessandra Filabozzi ◽  
Matthias Heyden
Keyword(s):  
High Frequency ◽  
Brillouin Scattering ◽  
Bulk Water ◽  
Density Fluctuations ◽  
Pressure Effects ◽  
Protein Solutions ◽  
Protein Hydration ◽  
Water Density ◽  
Dynamics Simulations ◽  
Induced Changes

Neutron Brillouin scattering and molecular dynamics simulations have been used to investigate protein hydration water density fluctuations as a function of pressure. Our results show significant differences between the pressure and density dependence of collective dynamics in bulk water and in concentrated protein solutions. Pressure-induced changes in the tetrahedral order of the water HB network have direct consequences for the high-frequency sound velocity and damping coefficients, which we find to be a sensitive probe for changes in the HB network structure as well as the wetting of biomolecular surfaces.

Dielectric spectra broadening as a signature for dipole–matrix interactions. V. Water in protein solutions

2020 ◽  
Vol 153 (4) ◽  
pp. 045102 ◽  
Author(s):  
Larisa Latypova ◽  
Alexander Puzenko ◽  
Evgeniya Levy ◽  
Yuri Feldman
Keyword(s):  
Protein Solutions ◽  
Dielectric Spectra ◽  
Matrix Interactions
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