Fundamental study of hydrogen-attachment-induced peptide fragmentation occurring in the gas phase and during the matrix-assisted laser desorption/ionization process

2018 ◽  
Vol 20 (18) ◽  
pp. 13057-13067 ◽  
Author(s):  
Daiki Asakawa ◽  
Hidenori Takahashi ◽  
Shinichi Iwamoto ◽  
Koichi Tanaka
Keyword(s):  
Gas Phase ◽  
Laser Desorption ◽  
Peptide Fragmentation ◽  
Laser Desorption Ionization ◽  
Fundamental Study ◽  
The Matrix ◽  
Fragmentation Techniques ◽  
Hydrogen Radical ◽  
Matrix Assisted Laser ◽  
Matrix Assisted Laser Desorption

Mass spectrometry with hydrogen-radical-mediated fragmentation techniques has been used for the sequencing of proteins/peptides.

scholarly journals Cyanocobalamin conjugates of cisplatin and diaminocyclohexane-platinum(ii): matrix-assisted laser desorption ionization mass spectrometry characterization using 4-chloro-α-cyanocinnamic acid as the matrix

RSC Advances ◽  
2017 ◽  
Vol 7 (85) ◽  
pp. 53658-53666 ◽  
Author(s):  
G. Ventura ◽  
F. Arnesano ◽  
C. D. Calvano ◽  
F. Palmisano ◽  
T. R. I. Cataldi
Keyword(s):  
Mass Spectrometry ◽  
Chemotherapeutic Agent ◽  
Laser Desorption ◽  
Ionization Mass ◽  
Laser Desorption Ionization ◽  
Malignant Tumours ◽  
Desorption Ionization ◽  
The Matrix ◽  
Matrix Assisted Laser ◽  
Matrix Assisted Laser Desorption

cis-Diamminedichloroplatinum(ii), also known as cisplatin, is a widely used chemotherapeutic agent to treat several malignant tumours, but unfortunately it causes serious side effects, especially nausea, vomiting and nephrotoxicity.

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