Enzyme-responsive sulfatocyclodextrin/prodrug supramolecular assembly for controlled release of anti-cancer drug chlorambucil

2019 ◽  
Vol 55 (7) ◽  
pp. 953-956 ◽  
Author(s):  
Xinran Guan ◽  
Yong Chen ◽  
Xuan Wu ◽  
Peiyu Li ◽  
Yu Liu
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Supramolecular Assembly ◽  
Controlled Drug Release ◽  
Cancer Drug ◽  
Anti Cancer

A supramolecular assembly constructed using sulfatocyclodextrin and choline modified chlorambucil exhibits excellent enzyme-response activity and controlled drug release.

scholarly journals Fabrication of Photothermo-Responsive Drug-Loaded Nanogel for Synergetic Cancer Therapy

Polymers ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 1098 ◽  
Author(s):  
Ray Chang ◽  
Wei-Bor Tsai
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Controlled Drug Release ◽  
Green Laser ◽  
Cancer Drug ◽  
Cell Mortality ◽  
Anti Cancer ◽  
Temperature Stimulus ◽  
Sodium Copper Chlorophyllin ◽  
532 Nm

Temperature stimulus, easy modulation in comparison to other environmental stimuli, makes thermo-responsive nanocarriers popular in the applications of controlled drug release for cancer therapy. In this study, photosensitive sodium copper chlorophyllin (SCC) was incorporated into thermo-responsive polymeric nanogels consisted of N-isopropylacrylamide and N-(hydroxymethyl)acrylamide. Significant heat was generated from the SCC-containing nanogels under the exposure to 532-nm green laser, and resulted in cell mortality. The thermo-responsive nanogel loaded with 5-FU, an anti-cancer drug, released the drug explosively when exposed to green laser. The combination of hyperthermia and temperature-induced drug release via green laser irradiation greatly enhanced cell mortality to a maximal extent. Such photothermo-responsive nanogel possesses a great potential in anti-cancer treatment.

Fabrication of PVCL-co-PMMA nanofibers with tunable volume phase transition temperatures and maintainable shape for anti-cancer drug release

RSC Advances ◽  
2015 ◽  
Vol 5 (80) ◽  
pp. 64944-64950 ◽  
Author(s):  
Zaiqian Yu ◽  
Hongjuan Gu ◽  
Dongyan Tang ◽  
Haitao Lv ◽  
Yonghui Ren ◽  
...  
Keyword(s):  
Phase Transition ◽  
Controlled Release ◽  
Drug Release ◽  
Anticancer Drugs ◽  
Cancer Drug ◽  
Volume Phase Transition ◽  
Transition Temperatures ◽  
Volume Phase ◽  
Anti Cancer ◽  
Phase Transition Temperatures

Thermo responsive PVCL-co-PMMA nanofibers for controlled release of anticancer drugs were fabricated. The thermo response temperatures of the nanofibers could be easily tuned, and the fibrous shapes could be maintained after heating–cooling cycles.

scholarly journals Hyaluronic Acid and Controlled Release: A Review

Molecules ◽  
2020 ◽  
Vol 25 (11) ◽  
pp. 2649 ◽  
Author(s):  
Ilker S. Bayer
Keyword(s):  
Hyaluronic Acid ◽  
Controlled Release ◽  
Drug Release ◽  
Controlled Drug Release ◽  
Surface Glycoprotein ◽  
Cancer Drug ◽  
Therapeutic Effects ◽  
Sustained Drug Release ◽  
Cell Surface Glycoprotein

Hyaluronic acid (HA) also known as hyaluronan, is a natural polysaccharide—an anionic, non-sulfated glycosaminoglycan—commonly found in our bodies. It occurs in the highest concentrations in the eyes and joints. Today HA is used during certain eye surgeries and in the treatment of dry eye disease. It is a remarkable natural lubricant that can be injected into the knee for patients with knee osteoarthritis. HA has also excellent gelling properties due to its capability to bind water very quickly. As such, it is one the most attractive controlled drug release matrices and as such, it is frequently used in various biomedical applications. Due to its reactivity, HA can be cross-linked or conjugated with assorted bio-macromolecules and it can effectively encapsulate several different types of drugs, even at nanoscale. Moreover, the physiological significance of the interactions between HA and its main membrane receptor, CD44 (a cell-surface glycoprotein that modulates cell–cell interactions, cell adhesion and migration), in pathological processes, e.g., cancer, is well recognized and this has resulted in an extensive amount of studies on cancer drug delivery and tumor targeting. HA acts as a therapeutic but also as a tunable matrix for drug release. Thus, this review focuses on controlled or sustained drug release systems assembled from HA and its derivatives. More specifically, recent advances in controlled release of proteins, antiseptics, antibiotics and cancer targeting drugs from HA and its derivatives were reviewed. It was shown that controlled release from HA has many benefits such as optimum drug concentration maintenance, enhanced therapeutic effects, improved efficiency of treatment with less drug, very low or insignificant toxicity and prolonged in vivo release rates.

scholarly journals Carrier-Free Microspheres of an Anti-Cancer Drug Synthesized via a Sodium Catalyst for Controlled-Release Drug Delivery

Materials ◽  
2018 ◽  
Vol 11 (2) ◽  
pp. 281 ◽  
Author(s):  
Yong Xie ◽  
Xinxin Ma ◽  
Xujie Liu ◽  
Qingming Long ◽  
Yu Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Cancer Drug ◽  
Release Drug ◽  
Anti Cancer ◽  
Carrier Free

scholarly journals ATRP-based synthesis of a pH-sensitive amphiphilic block polymer and its self-assembled micelles with hollow mesoporous silica as DOX carriers for controlled drug release

RSC Advances ◽  
2021 ◽  
Vol 11 (48) ◽  
pp. 29986-29996
Author(s):  
Xiuxiu Qi ◽  
Hongmei Yan ◽  
Yingxue Li
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Self Assembly ◽  
Drug Loading ◽  
Controlled Drug Release ◽  
Ph Sensitive ◽  
Core Shell ◽  
Assembly Process ◽  
Block Polymer ◽  
Hollow Mesoporous Silica

A pH-sensitive core–shell nanoparticle (HMS@C18@PSDMA-b-POEGMA) was developed via a self-assembly process as the carrier of anticancer drug doxorubicin (DOX) for drug loading and controlled release.

scholarly journals Mechanochemical Approaches Towards the in Situ Confinement of 5-FU Anti-Cancer Drug Within MIL-100 (Fe) Metal-Organic Framework

2020 ◽  
Author(s):  
Barbara Souza ◽  
Jin-Chong Tan
Keyword(s):  
Drug Release ◽  
Metal Organic Framework ◽  
Cancer Drug ◽  
One Pot ◽  
Host Interactions ◽  
Anti Cancer ◽  
Metal Organic ◽  
Iron Based ◽  
Organic Framework

We report two solvent-free mechanochemical methods to achieve one‑pot encapsulation of anti-cancer drug 5‑Fluorouracil (5‑FU) in the iron-based MIL‑100 metal-organic framework (MOF). We compare the structural and physicochemical properties of drug@MIL‑100 systems derived from <i>in situ </i>manual and vortex grinding, where the former exhibits a slower drug release due to stronger guest-host interactions.

scholarly journals Modeling of Anti-Cancer Drug Release Kinetics From Liposomes and Micelles: A Review

2021 ◽  
Vol 20 (4) ◽  
pp. 565-576
Author(s):  
Nour Al Sawaftah ◽  
Vinod Paul ◽  
Nahid Awad ◽  
Ghaleb A. Husseini
Keyword(s):  
Drug Release ◽  
Release Kinetics ◽  
Cancer Drug ◽  
Drug Release Kinetics ◽  
Anti Cancer

Surfactant-Based Anhydrous Nano Carrier System for Poorly Aqueous Soluble Anti-Cancer Drugs

2021 ◽  
pp. 413-432
Author(s):  
Shekhar Verma ◽  
Nagendra Chandrawanshi ◽  
Vishal Jain
Keyword(s):  
Controlled Release ◽  
Primary Objective ◽  
Water Soluble ◽  
Cancer Drug ◽  
Cancer Drugs ◽  
Carrier System ◽  
Anti Cancer ◽  
New Chemical Entities ◽  
Poorly Water Soluble ◽  
Nano Emulsion

Around 40% of new chemical entities and drugs are lipophilic or poor aqueous soluble in nature. Among them many anti-cancer drugs are also consist lipophilic properties. Available poorly water soluble anti-cancer drugs are paclitaxel, etoposide, and docetaxel. To get better stability of those anti-cancer drug via encapsulation and searching suitable carrier system for the controlled release, design and development requires of anhydrous nano carrier system. However, to deliver and entrapment of these kind of anti-cancer drugs are very essential with avoidance of water free preparation to get suitable controlled release application and achieve targeting site. The primary objective of proposed chapter is to develop and design novel stable anhydrous or non-aqueous nano emulsion carrier system and provide suitable carrier system for poorly aqueous soluble anti-cancer drugs. Another important aim is to design and develop better stabilizing agent by combining different type of surfactant, co-surfactant, and co-solvent.

Cap-free dual stimuli-responsive biodegradable nanocarrier for controlled drug release and chemo-photothermal therapy

2018 ◽  
Vol 6 (48) ◽  
pp. 8188-8195 ◽  
Author(s):  
Fang Wang ◽  
Zemin Wang ◽  
Yansheng Li ◽  
Liang Zhao ◽  
Yongqiang Wen ◽  
...  
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Photothermal Therapy ◽  
Controlled Drug Release ◽  
Stimuli Responsive

The cap-free nanocarrier with fast biodegradability achieved controlled release and chemo-photothermal therapy in vitro.

scholarly journals Development of Polymeric Blend Microspheres from Chitosan-Hydroxypropylmethyl Cellulose for Controlled Release of an Anti-Cancer Drug

2013 ◽  
Vol 57 (4) ◽  
pp. 439-446 ◽  
Author(s):  
Lakshmi C. Narayana Reddy ◽  
Rama Subba P. Reddy ◽  
Krishna K.S.V. Rao ◽  
M.C.S. Subha ◽  
Chowdoji K. Rao
Keyword(s):  
Controlled Release ◽  
Cancer Drug ◽  
Hydroxypropylmethyl Cellulose ◽  
Anti Cancer ◽  
Polymeric Blend
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