Design of specific inhibitors of quinolinate synthase based on [4Fe–4S] cluster coordination

Jaione Saez Cabodevilla; Anne Volbeda; Olivier Hamelin; Jean-Marc Latour; Océane Gigarel; Martin Clémancey; Claudine Darnault; Debora Reichmann; Patricia Amara; Juan C. Fontecilla-Camps; Sandrine Ollagnier de Choudens

doi:10.1039/c8cc09023h

Design of specific inhibitors of quinolinate synthase based on [4Fe–4S] cluster coordination

Chemical Communications ◽

10.1039/c8cc09023h ◽

2019 ◽

Vol 55 (26) ◽

pp. 3725-3728 ◽

Cited By ~ 1

Author(s):

Jaione Saez Cabodevilla ◽

Anne Volbeda ◽

Olivier Hamelin ◽

Jean-Marc Latour ◽

Océane Gigarel ◽

...

Keyword(s):

Quinolinic Acid ◽

Multidisciplinary Approach ◽

Action Mode ◽

Quinolinate Synthase ◽

Specific Inhibitors

A multidisciplinary approach allowed to identify specific inhibitors of quinolinate synthase, a [4Fe–4S]-containing enzyme involved in the formation of quinolinic acid and their action mode.

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Metabolic engineering of Escherichia coli for quinolinic acid production by assembling L-aspartate oxidase and quinolinate synthase as an enzyme complex

Metabolic Engineering ◽

10.1016/j.ymben.2021.06.007 ◽

2021 ◽

Author(s):

Fayin Zhu ◽

Matthew Peña ◽

George N. Bennett

Keyword(s):

Escherichia Coli ◽

Metabolic Engineering ◽

Quinolinic Acid ◽

Acid Production ◽

Enzyme Complex ◽

Quinolinate Synthase

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Structure of Quinolinate Synthase from Pyrococcus horikoshii in the Presence of Its Product, Quinolinic Acid

Journal of the American Chemical Society ◽

10.1021/jacs.6b02708 ◽

2016 ◽

Vol 138 (23) ◽

pp. 7224-7227 ◽

Cited By ~ 11

Author(s):

Olga A. Esakova ◽

Alexey Silakov ◽

Tyler L. Grove ◽

Allison H. Saunders ◽

Martin I. McLaughlin ◽

...

Keyword(s):

Quinolinic Acid ◽

Pyrococcus Horikoshii ◽

Quinolinate Synthase

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AAC Supports for Individuals With Rett Syndrome Across the Lifespan

Perspectives on Augmentative and Alternative Communication ◽

10.1044/aac24.3.74 ◽

2015 ◽

Vol 24 (3) ◽

pp. 74-85

Author(s):

Sandra M. Grether

Keyword(s):

Rett Syndrome ◽

Communication Skills ◽

Preliminary Analysis ◽

Multidisciplinary Approach ◽

Motor Deficits ◽

Complex Profile ◽

Communication Behaviors ◽

The Individual

Individuals with Rett syndrome (RS) present with a complex profile. They benefit from a multidisciplinary approach for diagnosis, treatment, and follow-up. In our clinic, the Communication Matrix © (Rowland, 1990/1996/2004) is used to collect data about the communication skills and modalities used by those with RS across the lifespan. Preliminary analysis of this data supports the expected changes in communication behaviors as the individual with RS ages and motor deficits have a greater impact.

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Traumatic Brain Injury: A Trauma Surgeon's Perspective

Perspectives on Neurophysiology and Neurogenic Speech and Language Disorders ◽

10.1044/nnsld22.3.82 ◽

2012 ◽

Vol 22 (3) ◽

pp. 82-89

Author(s):

Oscar D. Guillamondegui

Keyword(s):

Traumatic Brain Injury ◽

Brain Injury ◽

Multidisciplinary Approach ◽

Trauma Team ◽

The United States ◽

Long Term Outcomes ◽

Term Care ◽

Injured Brain ◽

The Moment

Traumatic brain injury (TBI) is a serious epidemic in the United States. It affects patients of all ages, race, and socioeconomic status (SES). The current care of these patients typically manifests after sequelae have been identified after discharge from the hospital, long after the inciting event. The purpose of this article is to introduce the concept of identification and management of the TBI patient from the moment of injury through long-term care as a multidisciplinary approach. By promoting an awareness of the issues that develop around the acutely injured brain and linking them to long-term outcomes, the trauma team can initiate care early to alter the effect on the patient, family, and community. Hopefully, by describing the care afforded at a trauma center and by a multidisciplinary team, we can bring a better understanding to the armamentarium of methods utilized to treat the difficult population of TBI patients.

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Percutaneous Tracheostomy: A Multidisciplinary Approach

Perspectives on Voice and Voice Disorders ◽

10.1044/vvd18.2.87 ◽

2008 ◽

Vol 18 (2) ◽

pp. 87-98 ◽

Cited By ~ 3

Author(s):

Vinciya Pandian ◽

Thai Tran Nguyen ◽

Marek Mirski ◽

Nasir Islam Bhatti

Keyword(s):

Health Care ◽

Quality Assurance ◽

Data Collection ◽

Health Care Professionals ◽

Multidisciplinary Approach ◽

Percutaneous Tracheostomy ◽

Johns Hopkins Hospital ◽

Prospective Data ◽

Comprehensive Service ◽

Over Time

Abstract The techniques of performing a tracheostomy has transformed over time. Percutaneous tracheostomy is gaining popularity over open tracheostomy given its advantages and as a result the number of bedside tracheostomies has increased necessitating the need for a Percutaneous Tracheostomy Program. The Percutaneous Tracheostomy Program at the Johns Hopkins Hospital is a comprehensive service that provides care to patients before, during, and after a tracheostomy with a multidisciplinary approach aimed at decreasing complications. Education is provided to patients, families, and health-care professionals who are involved in the management of a tracheostomy. Ongoing prospective data collection serves as a tool for Quality Assurance.

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