Structure of Quinolinate Synthase from Pyrococcus horikoshii in the Presence of Its Product, Quinolinic Acid

2016 ◽  
Vol 138 (23) ◽  
pp. 7224-7227 ◽  
Author(s):  
Olga A. Esakova ◽  
Alexey Silakov ◽  
Tyler L. Grove ◽  
Allison H. Saunders ◽  
Martin I. McLaughlin ◽  
...  
Keyword(s):  
Quinolinic Acid ◽  
Pyrococcus Horikoshii ◽  
Quinolinate Synthase

Design of specific inhibitors of quinolinate synthase based on [4Fe–4S] cluster coordination

2019 ◽  
Vol 55 (26) ◽  
pp. 3725-3728 ◽  
Author(s):  
Jaione Saez Cabodevilla ◽  
Anne Volbeda ◽  
Olivier Hamelin ◽  
Jean-Marc Latour ◽  
Océane Gigarel ◽  
...  
Keyword(s):  
Quinolinic Acid ◽  
Multidisciplinary Approach ◽  
Action Mode ◽  
Quinolinate Synthase ◽  
Specific Inhibitors

A multidisciplinary approach allowed to identify specific inhibitors of quinolinate synthase, a [4Fe–4S]-containing enzyme involved in the formation of quinolinic acid and their action mode.

Nomenclature Abstract for Pyrococcus horikoshii González et al. 1999.

2003 ◽  
Author(s):  
Charles Thomas Parker ◽  
Sarah Wigley ◽  
George M Garrity
Keyword(s):  
Pyrococcus Horikoshii

scholarly journals Increased serum QUIN/KYNA is a reliable biomarker of post-stroke cognitive decline

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Adrien Cogo ◽  
Gabrielle Mangin ◽  
Benjamin Maïer ◽  
Jacques Callebert ◽  
Mikael Mazighi ◽  
...  
Keyword(s):  
White Matter ◽  
Cerebral Artery ◽  
Quinolinic Acid ◽  
Neuronal Death ◽  
Artery Occlusion ◽  
Serum Biomarkers ◽  
Diabetic Mice ◽  
Stroke Patients ◽  
Cerebral Artery Occlusion

Abstract Background Strokes are becoming less severe due to increased numbers of intensive care units and improved treatments. As patients survive longer, post-stroke cognitive impairment (PSCI) has become a major health public issue. Diabetes has been identified as an independent predictive factor for PSCI. Here, we characterized a clinically relevant mouse model of PSCI, induced by permanent cerebral artery occlusion in diabetic mice, and investigated whether a reliable biomarker of PSCI may emerge from the kynurenine pathway which has been linked to inflammatory processes. Methods Cortical infarct was induced by permanent middle cerebral artery occlusion in male diabetic mice (streptozotocin IP). Six weeks later, cognitive assessment was performed using the Barnes maze, hippocampi long-term potentiation using microelectrodes array recordings, and neuronal death, white matter rarefaction and microglia/macrophages density assessed in both hemispheres using imunohistochemistry. Brain and serum metabolites of the kynurenin pathway were measured using HPLC and mass fragmentography. At last, these same metabolites were measured in the patient’s serum, at the acute phase of stroke, to determine if they could predict PSCI 3 months later. Results We found long-term spatial memory was impaired in diabetic mice 6 weeks after stroke induction. Synaptic plasticity was completely suppressed in both hippocampi along with increased neuronal death, white matter rarefaction in both striatum, and increased microglial/macrophage density in the ipsilateral hemisphere. Brain and serum quinolinic acid concentrations and quinolinic acid over kynurenic acid ratios were significantly increased compared to control, diabetic and non-diabetic ischemic mice, where PSCI was absent. These putative serum biomarkers were strongly correlated with degradation of long-term memory, neuronal death, microglia/macrophage infiltration and white matter rarefaction. Moreover, we identified these same serum biomarkers as potential predictors of PSCI in a pilot study of stroke patients. Conclusions we have established and characterized a new model of PSCI, functionally and structurally, and we have shown that the QUIN/KYNA ratio could be used as a surrogate biomarker of PSCI, which may now be tested in large prospective studies of stroke patients.

Increased serum levels of quinolinic acid indicate enhanced severity of hepatic dysfunction in patients with liver cirrhosis

2013 ◽  
Vol 74 (1) ◽  
pp. 60-66 ◽  
Author(s):  
Imad Lahdou ◽  
Mahmoud Sadeghi ◽  
Hani Oweira ◽  
Gerhard Fusch ◽  
Volker Daniel ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Quinolinic Acid ◽  
Hepatic Dysfunction ◽  
Serum Levels
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